Epidemiologic examinations of non-heritable risk factors for cognitive function and effect on health-related QOL

• Project/Area Number: 22790566
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Public health/Health science
• Research Institution: Nara Medical University
• Principal Investigator: OKAMOTO NOZOMI 奈良県立医科大学, 医学部, 講師 (70364057)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 認知機能 / 口腔衛生 / 健康関連ＱＯＬ / 残存歯数 / 歯周病 / 現在歯数 / 健康関連QOL / 日本語版開発 / 再現性 / 妥当性

Outline of Final Research Achievements

This was a prospective cohort study which aimed to investigate relationships between tooth loss and cognitive impairment. We also developed the Japanese version of the 15D, which was a comprehensive health-related quality of life questionnaire.　The subjects were 4427 community-dwelling independent elderly people at baseline. We performed a follow-up examination in the fifth year. We observed a significant association between total tooth loss, progression to edentulism in the group with a few number of teeth, and the development of mild memory impairment, even after adjustment for confounding factors.　Because of the short time required to complete the Japanese 15D and the significant relationships between the 15D and higher-level functional capacity, the acceptability and validity of the Japanese 15D were considered to be sufficient.

Research Products

• [Journal Article] Association between tooth loss and the development of mild memory impairment in the elderly: the Fujiwara-kyo study. (2015)
  • Author(s): Okamoto N, Morikawa M, Tomioka K, Yanagi M, Amano N, Kurumatanai N.
  • Journal Title: J Alzheimers Dis Volume: 44 Issue: 3 Pages: 777-786
  • DOI: 10.3233/jad-141665
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trabecular bone score may improve FRAX prediction accuracy for major osteoporotic fractures in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in men (FORMEN) Study. (2015)
  • Author(s): Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Sato Y, Moon JS, Winzenrieth R, Okamoto N, Kurumatani N.
  • Journal Title: Osteoporos Int Volume: 印刷中 Issue: 6 Pages: 1841-1848
  • DOI: 10.1007/s00198-015-3092-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Greater milk intake is associated with lower bone turnover, higher bone density, and higher bone microarchitecture index in a population of elderly Japanese men with relatively low dietary calcium intake: Fujiwara-kyo Osteoporosis Risk in men (FORMEN) Study. (2015)
  • Author(s): Sato Y, Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Moon JS, Winzenrieth R, Iwaki H, Ishizuka R, Amano N, Tomioka K, Okamoto N, Kurumatani N.
  • Journal Title: Osteoporos Int Volume: 印刷中 Issue: 5 Pages: 1585-1594
  • DOI: 10.1007/s00198-015-3032-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Walking Speed Associated with Self-Perceived Hearing Handicap in the High-Functioning Elderly: the Fujiwara-kyo Study. (2015)
  • Author(s): Tomioka K, Harano A, Hazaki K, Morikawa M, Iwamoto J, Saeki K, Okamoto N, Kurumatani N.
  • Journal Title: Geriatr Gerontol Int Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 健常高齢者とアルツハイマー型認知症患者における樹木画特徴の比較：冠状樹冠に注目して.最新精神医学 (2014)
  • Author(s): 谷村昌美、木内邦明、森川将行、岡本希、車谷典男、岸本年史、佐藤豪.
  • Journal Title: 最新精神医学 Volume: 19 Pages: 235-243
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between depressive symptoms and metabolic syndrome in Japanese community-dwelling older people: a cross-sectional analysis from the baseline results of the Fujiwara-kyo prospective cohort study. (2013)
  • Author(s): Morikawa M, Okamoto N, Kiuchi K, Tomioka K, Iwamoto J, Harano A, Saeki K, Fukusumi M, Hashimoto K, Amano N, Hazaki K, Yanagi M, Iki M, Yamada F, Kishimoto T, Kurumatani N.
  • Journal Title: Int J Geriatr Psychiatry Volume: 28 Issue: 12 Pages: 1251-1259
  • DOI: 10.1002/gps.3950
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Renal function and bone mineral density in community-dwelling elderly Japanese men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. (2013)
  • Author(s): Fujita Y, Iki M, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N.
  • Journal Title: Bone Volume: 56 Issue: 1 Pages: 61-66
  • DOI: 10.1016/j.bone.2013.05.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evaluation of factors influencing the natural history of nocturia in elderly subjects: results of the Fujiwara-kyo Study. (2013)
  • Author(s): Hirayama A, Torimoto K, Mastusita C, Okamoto N, Morikawa M, Tanaka N, Yoshida K, Fujimoto K, Hirao Y, Kurumatani N.
  • Journal Title: J Urol Volume: 189 Issue: 3 Pages: 980-986
  • DOI: 10.1016/j.juro.2012.09.118
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Hearing Handicap Inventory for Elderly-Screening (HHIE-S) versus a single question: reliability, validity, and relations with quality of life measures in the elderly community, Japan. (2013)
  • Author(s): Tomioka K, Ikeda H, Hanaie K, Morikawa M, Iwamoto J, Okamoto N, Saeki K, Kurumatani N.
  • Journal Title: Qual Life Res Volume: 22 Issue: 5 Pages: 1151-1159
  • DOI: 10.1007/s11136-012-0235-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 独歩可能な地域在住高齢者の日常生活活動の関連要因―大規模コホート研究（藤原京スタディ）ベースライン健診結果―. (2013)
  • Author(s): 小松雅代、根津智子、冨岡公子、羽崎完、原納明博、森川将行、高木正博、山田全啓、松本 善孝、岩本淳子、石塚理香、佐伯圭吾、岡本希、車谷典男.
  • Journal Title: 日本衛生学雑誌 Volume: 68 Pages: 22-32
  • NAID: 10031143698
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of the Japanese 15D Instrument of Health-Relataed Quality of Life: Verification of Reliability and Validity among Elderly People (2013)
  • Author(s): Nozomi Okamoto
  • Journal Title: PLOS ONE Volume: 8 Issue: 4 Pages: e61721-e61721
  • DOI: 10.1371/journal.pone.0061721
  • Peer Reviewed
• [Journal Article] Relationship between swallowing problems and tooth loss in community-dwelling independent elderly adults : the Fujiwara-kyo study (2012)
  • Author(s): Okamoto N, et al
  • Journal Title: J Am Geriatr Soc Volume: 60 Issue: 5 Pages: 849-853
  • DOI: 10.1111/j.1532-5415.2012.03935.x
  • Peer Reviewed
• [Presentation] Association between tooth loss and mild memory impairment in the elderly: the Fujiwara-kyo study (2014)
  • Author(s): Nozomi Okamoto, Masayuki Morikawa, Kimiko Tomioka, Motokazu Yanagi, Nozuko Amano, Norio Kurumatani
  • Organizer: ＷＰＡ Ｓｅｃｔｉｏｎ ｏｎ Ｅｐｉｄｅｍｉｏｌｏｇｙ ａｎｄ Ｐｕｂｌｉｃ Ｈｅａｌｔｈ 2014 Ｍｅｅｔｉｎｇ
  • Place of Presentation: Nara Prefectural New Public Hall
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 歯牙喪失と軽度認知機能障害との関連についての大規模コホート研究 (2014)
  • Author(s): 岡本希
  • Organizer: 日本口腔衛生学会
  • Place of Presentation: 熊本市
  • Year and Date: 2014-05-29 – 2014-05-31
• [Presentation] 健康関連QoL尺度15D日本語版の開発-信頼性と妥当性の検証- (2012)
  • Author(s): 岡本希, 久繁哲徳, 田中優, 車谷典男
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都,京都大学吉田キャンパス
  • Year and Date: 2012-03-25
• [Presentation] 残存歯数と軽度記憶障害および認知機能との関連-藤原京スタディ- (2010)
  • Author(s): 岡本希、森川将行、岩本淳子、岡本健介、佐伯圭吾、冨岡公子、車谷典男
  • Organizer: 第69回日本公衆衛生学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-28