| Project/Area Number |
22790570
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
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| Keywords | 白内障 / 緑内障 / 眼圧 / 予防医学 / 疫学 / コホート研究 / 加齢黄斑変性 / 疫学研究 |
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| Research Abstract |
This 5-year prospective population-based study was conducted, based on the data of a cohort of Japanese residents, in order to clarify the relationship of age-related cataracts to body mass index (BMI). The results demonstrated a U-shaped association between BMI and the incidence of cataract in Japanese men and women. The multivariate odds ratios of cataract for those in the lowest (<19.0) and the highest (>25.0) BMI categories, compared with a BMI category of 21.0-22.9.
In this cross-sectional and longitudinal studies, we attempted to clarify whether blood pressure (BP), BMI, and smoking was associated with elevated intraocular pressure (IOP). The results of this study showed suggest that BP and BMI had a significantly positive association with IOP and that smoking was associated with high IOP, especially with "high BP accompanied by high IOP". Longitudinal changes (average follow-up period of 3.6 years) in BP and BMI also had a significant positive association with that of IOP.
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