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Epidemiological Study on Colorectal Neoplastic lesions

Research Project

Project/Area Number 22790579
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionNational Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

Principal Investigator

YAMAJI Taiki  独立行政法人国立がん研究センター, がん予防・検診研究センター, 研究員 (10466203)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords大腸腺腫 / 内臓脂肪 / インスリン関連マーカー / アディポカイン / ビタミンD / ビタミンDレセプター遺伝子多型 / 環境-遺伝交互作用 / 疫学研究 / 隆起型大腸腺種 / 平坦型大腸腺腫 / 陥凹型大腸腺腫 / ビタミンDレセプター / バイオマーカー / 遺伝-環境交互作用 / 分子疫学研究 / 肥満 / 内臓肥満 / インスリン / インスリン様成長因子 / インスリン様成長因子結合蛋白 / 分子疫学
Research Abstract

Supported by Grant-in-Aid for Young Scientists B, this researcher conducted descriptive and analytical epidemiological studies on colorectal neoplastic lesions. In a descriptive epidemiological study, this researcher observed that the prevalence of depressed type colorectal adenoma was very rare(around 3%) in a general population. In analytical epidemiological studies, this researcher found several clues which may explain a positive association of obesity or a negative association of vitamin D with colorectal adenoma.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report

Research Products

(10 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Remarks (3 results)

  • [Journal Article] Association between plasma 25-hydroxyvitamin D and colorectal adenoma according to dietary calcium intake and vitamin D receptor polymorphism2012

    • Author(s)
      Yamaji T, Iwasaki M, Sasazuki S, Sakamoto H, Yoshida T, Tsugane S.
    • Journal Title

      Am J Epidemiol

      Volume: 175(3) Issue: 3 Pages: 236-44

    • DOI

      10.1093/aje/kwr295

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gender difference in the association of insulin and the insulin-like growth factor axis with colorectal neoplasia2012

    • Author(s)
      Yamaji T, Iwasaki M, Sasazuki S, Tsugane S.
    • Journal Title

      Int J Obes

      Volume: 36(3) Issue: 3 Pages: 440-7

    • DOI

      10.1038/ijo.2011.114

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gender difference in the association of insulin and the insulin-like growth factor axis with colorectal neoplasia2011

    • Author(s)
      Taiki Yamaji, et.al
    • Journal Title

      International Journal of Obesity

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血漿ビタミンD濃度およびビタミンDレセプター遺伝子多型と大腸腺腫との関連2011

    • Author(s)
      山地太樹・岩崎基・笹月静・坂本裕美・吉田輝彦・津金昌一郎
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 大腸発がん初期段階におけるアディポネクチンとレプチンとの交互作用2010

    • Author(s)
      山地太樹・岩崎基・笹月静・津金昌一郎
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル大阪(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 大腸発がん初期段階におけるアディポネクチンとレプチンとの交互作用2010

    • Author(s)
      山地太樹, 他
    • Organizer
      第69回 日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル大阪(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 内臓脂肪体積と大腸腺腫との関連2010

    • Author(s)
      山地太樹・岩崎基・笹月静・澤田典絵・津金昌一郎
    • Organizer
      がん予防学術大会2010
    • Place of Presentation
      北海道大学学術交流会館(北海道)
    • Year and Date
      2010-07-15
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Remarks]

    • URL

      http://epi.ncc.go.jp/mstudy/132/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://epi.ncc.go.jp/mstudy/132/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://epi.ncc.go.jp/mstudy/132/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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