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A longitudinal study of fatty acid intake and cognitive function

Research Project

Project/Area Number 22790584
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

OTSUKA REI  独立行政法人国立長寿医療研究センター, NILS-LSA活用研究室, 室長 (00532243)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,288,028 (Direct Cost: ¥2,529,253、Indirect Cost: ¥758,775)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥428,028 (Direct Cost: ¥329,253、Indirect Cost: ¥98,775)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords脂肪酸 / 認知機能 / ドコサヘキサエン酸 / 疫学
Research Abstract

This study was conducted to verify the relationship between fatty acids and cognitive function from the longitudinal data of middle-aged and elderly community residents, aiming to prevent cognitive decline through the diet. The relationship of fatty acid intake (45 types) and serum fatty acid concentration (24 fractions) with cognitive function was thoroughly investigated. Out of the various fatty acids, low serum docosahexaenoic acid (DHA) was found to be at high risk of cognitive decline after 10 years. Since there is a positive correlation between DHA intake from the diet and serum DHA concentrations, we found that there is a possibility that consumption of DHA-rich, blue fish could prevent cognitive decline.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (25 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (14 results) Remarks (3 results)

  • [Journal Article] Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese2014

    • Author(s)
      Otsuka R, Tange C, Nishita Y, Kato Y, Imai T, Ando F, Shimokata H
    • Journal Title

      Eur J Clin Nutr

      Volume: 68(4) Pages: 503-509

    • Related Report
      2013 Final Research Report
  • [Journal Article] Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese.2014

    • Author(s)
      Otsuka R, Tange C, Nishita Y, Kato Y, Imai T, Ando F, Shimokata H
    • Journal Title

      Eur J Clin Nutr

      Volume: 68(4) Issue: 4 Pages: 503-509

    • DOI

      10.1038/ejcn.2013.264

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher serum EPA or DHA, and lower ARA compositions with age independent of fatty acid intake in Japanese aged 40 to 792013

    • Author(s)
      Otsuka R, Kato Y, Imai T, Ando F, Shimokata H
    • Journal Title

      Lipids

      Volume: 48(7) Pages: 719-27

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 地域在住中高年男女における出生コホート別の10年間の魚介類およびEPA・DHA摂取量の推移2013

    • Author(s)
      大塚礼,加藤友紀,今井具子,安藤富士子,下方浩史
    • Journal Title

      栄養学雑誌

      Volume: 71(4) Pages: 185-195

    • NAID

      10031194264

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 地域在住中高年男女における性・年齢群別の血清脂肪酸構成比率2013

    • Author(s)
      大塚礼,加藤友紀,今井具子,安藤富士子,下方浩史
    • Journal Title

      日本栄養・食糧学会誌

      Volume: 66(3) Pages: 147-153

    • NAID

      10031175977

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Higher serum EPA or DHA, and lower ARA compositions with age independent of fatty acid intake in Japanese aged 40 to 792013

    • Author(s)
      Otsuka Rei
    • Journal Title

      Lipids

      Volume: in press Issue: 7 Pages: 719-727

    • DOI

      10.1007/s11745-013-3763-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 地域在住中高年男女における性・年齢群別の血清脂肪酸構成比率2013

    • Author(s)
      大塚礼
    • Journal Title

      日本栄養・食糧学会誌

      Volume: 印刷中

    • NAID

      10031175977

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased salt intake in Japanese males aged 40 to 70 years and females aged 70 to 79 years : An 8-year longitudinal study2011

    • Author(s)
      Otsuka R, Kato Y, Imai T, Ando F, Shimokata H
    • Journal Title

      J Am Diet Assoc.

      Volume: 111 Pages: 844-850

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血清DHA, EPA濃度に対する性, 年齢, 生活習慣等の影響 ~中高年男女における検討~2013

    • Author(s)
      大塚礼, 加藤友紀, 安藤富士子, 下方浩史
    • Organizer
      第49回日本循環器病管理予防学会
    • Place of Presentation
      金沢
    • Year and Date
      2013-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 60歳以上男女での血清DHA, EPA濃度と10年後の認知機能低下との関連2013

    • Author(s)
      大塚礼, 加藤友紀, 西田裕紀子, 丹下智香子, 安藤富士子, 下方浩史
    • Organizer
      第28回日本老年学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2013-06-05
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム「油脂・脂肪酸と脳機能/感覚科学の研究最前線」中高年者の多価不飽和脂肪酸摂取と知能・認知機能に関する長期縦断疫学研究2013

    • Author(s)
      大塚礼, 下方浩史
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-05-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 血清中のn-3系およびn-6系多価不飽和脂肪酸濃度と認知機能との関連2013

    • Author(s)
      大塚礼, 西田裕紀子, 丹下智香子, 加藤友紀, 安藤富士子, 下方浩史
    • Organizer
      第23回日本疫学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2013-01-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 地域在住中高年男女における年齢群別のDHAとEPA摂取量の推移(10年間)2012

    • Author(s)
      大塚礼, 加藤友紀, 今井具子, 安藤富士子, 下方浩史
    • Organizer
      第59回日本栄養改善学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 地域在住高齢男女におけるn-3系およびn-6系多価不飽和脂肪酸摂取量と認知機能との関連2012

    • Author(s)
      大塚礼, 加藤友紀, 西田裕紀子, 丹下智香子, 今井具子, 安藤富士子, 下方浩史
    • Organizer
      第54回日本老年医学会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪酸摂取、血清脂肪酸と認知機能に関する栄養疫学研究~DHA,EPA,アラキドン酸に注目した横断解析結果を中心に~2011

    • Author(s)
      大塚礼
    • Organizer
      第21回認知症先進医療開発センターCAMD報告会
    • Place of Presentation
      愛知県
    • Year and Date
      2011-02-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 地域在住中高年男女における多価不飽和脂肪酸摂取量と認知機能低下との関連2010

    • Author(s)
      大塚礼, 加藤友紀, 今井具子, 安藤富士子, 下方浩史
    • Organizer
      第32回日本臨床栄養学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 血清DHA、EPA濃度に対する性、年齢、生活習慣等の影響 ~中高年男女における検討~

    • Author(s)
      大塚礼、加藤友紀、安藤富士子、下方浩史
    • Organizer
      第49回日本循環器病管理予防学会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] 60歳以上男女での血清DHA、EPA濃度と10年後の認知機能低下との関連

    • Author(s)
      大塚礼、加藤友紀、西田裕紀子、丹下智香子、安藤富士子、下方浩史
    • Organizer
      第28回日本老年学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 中高年者の多価不飽和脂肪酸摂取と知能・認知機能に関する長期縦断疫学研究

    • Author(s)
      大塚礼、下方浩史
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血清中のn-3系およびn-6系多価不飽和脂肪酸濃度と認知機能との関連

    • Author(s)
      大塚礼
    • Organizer
      第23回日本疫学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 地域在住中高年男女における年齢群別のDHAとEPA摂取量の推移(10年間)

    • Author(s)
      大塚礼
    • Organizer
      第59回日本栄養改善学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 地域在住高齢男女におけるn-3系およびn-6系多価不飽和脂肪酸摂取量と認知機能との関連

    • Author(s)
      大塚礼
    • Organizer
      第54回日本老年医学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Remarks] 国立長寿医療研究センター・老化に関する長期縦断疫学研究 モノグラフ

    • URL

      http://www.ncgg.go.jp/department/ep/nilslsa.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 国立長寿医療研究センター 老化に関する長期縦断疫学研究

    • URL

      http://www.ncgg.go.jp/department/ep/index-j.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncgg.go.jp/department/ep/nilslsa.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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