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Comprehension of epidemiologic information and genomics of Mycobacterium tuberculosis clinical strains causing putative nationwide proliferation

Research Project

Project/Area Number 22790585
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionOsaka City Institute of Public Health and Environmental Sciences

Principal Investigator

WADA Takayuki  大阪市立環境科学研究所, 研究主任 (70332450)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords感染症 / ゲノム / 衛生 / 社会医学 / 分子疫学 / 公衆衛生 / 結核 / 細菌 / ゲノム比較
Research Abstract

Genotyping of clinical isolates of Mycobacterium tuberculosis has been used to estimate their putative transmission routes. In this study, we focused on two genotypes of M. tuberculosis, pECT04 and pECT07, detected occasionally from broad areas in Japan. Totally twelve clinical isolates of the genotypes were genomically sequenced for comparative analysis. Results show that phylogenetic relation among pECT07 isolates was not associated with their geographic origins, which suggests their complicated transmission routes around Japan. Contrary to pECT04, many SNPs characteristic to two isolates of pECT04 were identified. These results mean that comparative genomics of clinical isolates can provide deep traceability of transmission of M. tuberculosis that has never achieved with present genotyping methods.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011

All Presentation (8 results)

  • [Presentation] ゲノム比較に基づく結核菌臨床分離株の遺伝的多様性包囲網の構築2012

    • Author(s)
      和田崇之,岩本朋忠,長谷篤,前田伸司
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report
  • [Presentation] ゲノム比較に基づく結核菌臨床分離株の遺伝的多様性包囲網の構築2012

    • Author(s)
      和田崇之、岩本朋忠, 他
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Related Report
      2011 Annual Research Report
  • [Presentation] わが国における北京型結核菌の集団構造に即したVNTR型別データの考え方2011

    • Author(s)
      和田崇之,岩本朋忠
    • Organizer
      第85回日本感染症学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] ホームレス結核患者由来株のVNTR型別解析:多発性大規模伝播と未知の伝播経路推定2011

    • Author(s)
      和田崇之,小向潤,有馬和代,團野桂,松本健二,吉田英樹,加藤仁一,岩本朋忠,田丸亜貴,吉田志緒美,下内昭,長谷篤
    • Organizer
      第86回日本結核病学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of genomic specificity and diversity observed in Mycobacterium tuberculosis in far-eastern Asia2011

    • Author(s)
      Takayuki Wada, Tomotada Iwamoto, Atsushi Hase, and Shinji Maeda
    • Organizer
      FEMS Microbiology Congress 2011
    • Place of Presentation
      Geneva
    • Related Report
      2011 Final Research Report
  • [Presentation] わが国における北京型結核菌の集団構造に即したVNTR型別データの考え方2011

    • Author(s)
      和田崇之、岩本朋忠
    • Organizer
      第85回日本感染症学会総会
    • Place of Presentation
      パークタワー東京(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ホームレス結核患者由来株のVNTR型別解析:多発性大規模伝播と未知の伝播経路推定2011

    • Author(s)
      和田崇之、小向潤, 他
    • Organizer
      第86回日本結核病学会総会
    • Place of Presentation
      日本教育会館(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of genomic specificity and diversity observed in Mycobacterium tuberculosis in far-eastern Asia2011

    • Author(s)
      Wada T, Iwamoto T, et al
    • Organizer
      FEMS Microbiology Congress 2011
    • Place of Presentation
      Plexpo Geneva Congress Center (Switzerland)
    • Related Report
      2011 Annual Research Report

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Published: 2010-11-30   Modified: 2016-04-21  

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