| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Research Abstract |
In acute lung injury (ALI) induced by heat exposure and/or venous injection of oleic acid, Il-1β, IL-6, TNF-α, MIP2 and IL-10, which are related to inflammatory reaction, were increased at short times. In addition, IL-1β expressions of mRNA and protein were synergistically increased by venous injection of oleic acid after heat exposure, which suggested that prognosis of ALI induced by pulmonary fat embolization would be deteriorated by the severity of precedent injuries and/or diseases which can induce to pulmonary fat embolization. Moreover, mRNA expressions of vegfa, tgfb1 and gm-csf were also induced at short times after the insults, and TGF-β1 was significantly expressed as well as mRNA. These proteins would be available for evaluating general condition in forensic autopsy cases where the individual suddenly dies.
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