| Project/Area Number |
22790600
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
IHAMA Yoko 琉球大学, 医学研究科, 助教 (80347137)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 陰圧損傷 / 法医解剖 / 肉損傷 / 挫滅症候群 / 胸郭運動障害 / 呼吸障害 / 突然死 / 吸引損傷 / 陰圧 / 出血性ショック |
|---|
| Research Abstract |
In the present study, we used rat models to determine the morphological changes and investigate the mechanism underlying death caused by locallyapplied negative pressure. We found that morphological changes caused by locally applied negative pressure occurred in the early stages of the experiment, as opposed to that demonstrated by previous reports that used crush syndrome models and/or ischemic models. These results suggest that locally applied negative pressure directly causes muscle damage. Moreover, physiological studies revealed that negative pressure applied to the upper limb and chest brought about abrupt deaths, which possibly explain the mechanism underlying death caused by locally negative pressure. To the best of our knowledge, no experimental reports have been conducted on locally applied negative pressure. Therefore, this study presents valuable results.
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