| Project/Area Number |
22790603
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
SATO Takako 大阪医科大学, 医学部, 助教 (10530420)
|
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 法医病理学 / 乳幼児突然死症候群 / 質量顕微鏡 / ミエリン塩基性蛋白 |
|---|
| Research Abstract |
Sudden infant death syndrome(SIDS) is one of the major causes of infant mortality. However, the causes of SIDS are still unknown. It is pointed out that developmental delays in the central cardiovascular and respiratory regulation may be involved. Our research intended to examine whether myelin structural proteins, such as myelin basic protein(MBP), are useful as diagnostic markers of SIDS by direct analysis of brain tissue using imaging mass spectrometry. Paraffin-embedded sections seemed to be ideal because the cases have been accumulated, but they were found to be unsuitable for the analysis. Though frozen sections are suitable, the number of cases is insufficient. It is necessary to accumulate the number of samples for further study.
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