Neural bases underlying common psychological characteristics across psychosomatic diseases

• Project/Area Number: 22790611
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: SEKIGUCHI Atsushi 東北大学, 東北メディカル・メガバンク機構, 講師 (50547289)
• Co-Investigator(Renkei-kenkyūsha): KAWASHIMA Ryuta 東北大学, 加齢医学研究所, 教授 (90250828) ; SUGIURA Motoaki 東北大学, 加齢医学研究所, 准教授 (60396546) ; KOTOZAKI Yuka 東北大学, 加齢医学研究所, 研究員 (10569578) ; FUKUDO Shin 東北大学, 医学系研究科, 教授 (80199249) ; MORISHITA Joe 東北大学, 医学系研究科, 研究員 (00375031) ; AIZAWA Emiko 独立行政法人国立精神・神経医療研究センター, 神経研究所・疾病研究第三部, 研究員 (00639049)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脳・神経 / ストレス / 心身症 / 感情抑制 / 震災ストレス / 心身相関

Research Abstract

We investigated neural bases underlying common psychological characteristics among psychosomatic diseases, such as stress vulnerability and somatization, by using neuroimaging methods. The results suggested that neural correlates of stress vulnerability is related to dysfunction of the dorsolateral prefrontal cortex and the ventral anterior cingulate cortex, and those of somatization is related to altered activation patterns in the anterior insula and the somatosensory area. The results support the effectiveness of psychological intervention to the patients with any types of psychosomatic diseases.

Research Products

• [Journal Article] Brain structural changes as vulnerability factors and acquired signs of post-earthquake stress (2013)
  • Author(s): Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H,Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Kawashima R.
  • Journal Title: Molecular Psychiatry Volume: Vol 18 Issue: 5 Pages: 618-623
  • DOI: 10.1038/mp.2012.51
  • Peer Reviewed
• [Journal Article] Neural correlates of adaptive social responses to real-life frustrating situations: a functional MRI study (2013)
  • Author(s): Sekiguchi A, Sugiura M, Yokoyama S, Sassa Y, Horie K, Sato S, Kawashima R.
  • Journal Title: BMC neuroscinece Volume: 14 Issue: 1 Pages: 29-29
  • DOI: 10.1186/1471-2202-14-29
  • Peer Reviewed
• [Journal Article] 震災後精神症状の脆弱性・獲得因子の神経基盤の解明 (2013)
  • Author(s): 関口敦,杉浦元亮,事崎由佳,佐久間篤,瀧靖之,川島隆太
  • Journal Title: トラウマティック・ストレス Volume: vol.11-1
  • NAID: 40019899564
• [Journal Article] Causal Relationship Between Psychological Distress After a Severe Earthquake and Brain Structural Changes (2013)
  • Author(s): Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Kawashima R.
  • Journal Title: Human Science & Technology Volume: in press
  • Peer Reviewed
• [Journal Article] 震災後精神症状の脆弱性・獲得因子の神経基盤の解明 (2013)
  • Author(s): 関口敦, 杉浦元亮, 事崎由佳, 佐久間篤, 瀧靖之, 川島隆太
  • Journal Title: トラウマティック・ストレス Volume: in press
  • NAID: 40019899564
• [Journal Article] Causal Relationship Between Psychological Distress After a Severe Earthquake and Brain Structural Changes (2012)
  • Author(s): Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma a, Kawashima R.
  • Journal Title: Human Science & Technology Volume: Vol. 10
  • Peer Reviewed
• [Presentation] Resilience after 3/11: white matter microstructural changes one-year after the Japanese Earthquake (2013)
  • Author(s): Sekiguchi A, Sugiura M, Kotozaki Y, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Taki Y,Kawashima R
  • Organizer: The 19th Annual Meeting of the Organization for Human BrainMapping
  • Place of Presentation: Seattle, WA, USA
  • Year and Date: 2013-06-19
• [Presentation] 震災前後に認められた脳形態変化の追跡調査 (2013)
  • Author(s): 関口敦,事崎由佳,杉浦元亮,塙杉子,中川誠秀,宮内誠カルロス,佐久間篤,瀧靖之,川島隆太
  • Organizer: 第12回日本トラウマティック・ストレス学会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-11
• [Presentation] Resilience after 3/11: Brain structural changes one-year after the Great East Japan Earthquake (2013)
  • Author(s): Sekiguchi A, Sugiura M, Kotozaki Y, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Taki Y, Kawashima R
  • Organizer: The 71st Annual Meeting of the American Psychosomatic Society
  • Place of Presentation: Miami, FL, USA
  • Year and Date: 2013-03-14
• [Presentation] Resilience after 3/11: Brain structural changes one-year after the Great East Japan Earthquake (2013)
  • Author(s): Sekiguchi A, Sugiura M, Kotozaki Y, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Taki Y, Kawashima R
  • Organizer: 71st Annual Meeting of the American Psychosomatic Society
  • Place of Presentation: Miami, USA
• [Presentation] Resilience after 3/11: white matter microstructural changes one-year after the Japanese Earthquake (2013)
  • Author(s): Sekiguchi A, Sugiura M, Kotozaki Y, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Taki Y, Kawashima R
  • Organizer: 19th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Seattle, USA
• [Presentation] Brain structural changes as vulnerability factors and acquiredsigns of post-earthquake distress (2012)
  • Author(s): Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Kawashima R
  • Organizer: Society for Neuroscience 42nd Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2012-10-14
• [Presentation] 震災後精神症状の脆弱性/獲得因子の神経基盤の解明 (2012)
  • Author(s): 関口敦,杉浦元亮,事崎由佳,佐久間篤,川島隆太
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-09
• [Presentation] PTSD症状の脆弱性/獲得因子の神経基盤の解明～健常大学生における検討 (2012)
  • Author(s): 関口敦
  • Organizer: 第53回日本心身医学会総会
  • Place of Presentation: 鹿児島
  • Year and Date: 2012-05-25
• [Presentation] 過敏性腸症候群における情動制御の神経基盤の検討 (2012)
  • Author(s): 関口敦,杉浦元亮,森下城,事崎由佳,相澤恵美子,福土審,川島隆太
  • Organizer: 第78回消化器心身医学研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-20
• [Presentation] Decreased regional gray matter volume in the prefrontal cortices predicts a tendency for PTSD symptoms in healthy survivors of the Great East Japan Earthquake (2012)
  • Author(s): Sekiguchi A, Sugiura M, Kotozaki Y, Araki T, Hanawa S, Nakagawa S, Miyauchi MC, Sakuma A, Taki Y, Kawashima R
  • Organizer: The 70th Annual Meeting of the American Psychosomatic Society
  • Place of Presentation: Athens, Greece
  • Year and Date: 2012-03-14
• [Presentation] Brain structural changes as vulnerability factors and acquired signs of post-earthquake distress (2012)
  • Author(s): Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Kawashima R
  • Organizer: Society for Neuroscience 42nd Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Neural Substrates of Decision Making in Irritable Bowel Syndrome (2011)
  • Author(s): Aizawa E, Kochiyama T, Sato Y, Morishita J, Sekiguchi A, Kotozaki Y, Kano M, Kanazawa M, Sugiura M, Kawashima R, Mushiake H, Fukudo S
  • Organizer: Digestive Disease Week (DDW) 2011
  • Place of Presentation: Cicago, IL, USA
  • Year and Date: 2011-05-07
• [Presentation] Neural characteristics of cognitive control of negative emotion in subjects with irritable bowel syndrome (2011)
  • Author(s): Sekiguchi A, Sugiura M, Morishita J, Kotozaki Y, Aizawa E, Fukudo S, Kawashima R
  • Organizer: The 69th Annual Meeting of the American Psychosomatic Society
  • Place of Presentation: San Antonio, TX, USA
  • Year and Date: 2011-03-09
• [Presentation] Neural characteristics of cognitive control of negative emotion in subjects with irritable bowel syndrome (2011)
  • Author(s): 関口敦
  • Organizer: 第69回アメリカ心身医学会
  • Place of Presentation: サンアントニオ、アメリカ
  • Year and Date: 2011-03-09