Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Research Abstract |
Kakkonto, a traditional Japanese herbal medicine, suppressed the occurrence of allergic symptoms in an FA mouse model. Furthermore, Puerariae radix extract and several isoflavones suppressed the occurrence of allergic symptoms in an FA mouse model. The proportion of CD4+Foxp3+regulatory T cells in lamina propria was significantly increased bykakkonto treatment and isoflavones treatment as compared with FA mouse model. Our data suggest that CD4+Foxp3+regulatory T cells induced by kakkonto and isoflavones had suppressive effects on intestinal mucosal immunity in FA mice.
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