The effect of kakkonto in allergic immune response mediated by dendritic cells on intestinal mucosal immune system
| Project/Area Number |
22790616
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 東洋医学 / 葛根湯 / 腸管粘膜免疫 / 食物アレルギー / 制御性細胞 / 樹状細胞 / 腸管粘膜免疫系 / 制御性T細胞 |
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| Research Abstract |
Kakkonto, a traditional Japanese herbal medicine, suppressed the occurrence of allergic symptoms in an FA mouse model. Furthermore, Puerariae radix extract and several isoflavones suppressed the occurrence of allergic symptoms in an FA mouse model. The proportion of CD4+Foxp3+regulatory T cells in lamina propria was significantly increased bykakkonto treatment and isoflavones treatment as compared with FA mouse model. Our data suggest that CD4+Foxp3+regulatory T cells induced by kakkonto and isoflavones had suppressive effects on intestinal mucosal immunity in FA mice.
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Report
(4 results)
Research Products
(19 results)
