| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Short term treatment of traditional Japanese medicine “Rikkunshito (RKT)” increases plasma acyl-ghrelin, and stimulates food intake via hypothalamic NPY expression. This mechanism is similar to that of calorie restriction (CR). In this study, we investigated the possibility of RKT as the calorie restriction mimetic drug. Chronic RKT treatment increased acyl-ghrelin level, and enhanced oxidative stress resistance like the effect of CR. However, chronic RKT treatment could not extend lifespan. Interestingly, chronic RKT treatment from middle or old age significantly decreased white adipose tissue mass.Although it is necessary to clear more detail condition and molecular mechanisms of RKT treatment at the old age model, it is expected to apply anti-obesity drug.
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