The analysis of correlation between pancreatic fibrosis and pancreatic diabetes.

• Project/Area Number: 22790629
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: KIKUTA Kazuhiro 東北大学, 病院, 助教 (80420024)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 膵性糖尿病 / 膵線維化 / 膵星細胞 / 膵島細胞

Research Abstract

It remains unknown that pancreatic stellate cells (PSCs)play a role in the development of pancreatic diabetes. We examined the interaction between PSCs and pancreatic beta-cells. PSCs inhibited insulin expression and induced apoptosis of beta-cells, suggesting that PSCs might play a role in the development of pancreatic fibrosis and anti-fibrosis therapy targeting PSCs might be useful for the prevention of pancreatic diabetes.

Research Products

• [Journal Article] The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG2 (2012)
  • Author(s): Hamada S, Satoh K, Hirota M, Kanno A, Umino J, Ito H, Masamune A, Kikuta K, et al.
  • Journal Title: J Cell Physiol Volume: 227巻 Pages: 729-738
  • Peer Reviewed
• [Journal Article] MiR-126 Acts as a Tumor Suppressor in Pancreatic Cancer Cells via the Regulation of ADAM9 (2012)
  • Author(s): Hamada S, Satoh K, Fujibuchi W, Hirota M, Kanno A, Unno J, Masamune A, Kikuta K, et al.
  • Journal Title: Mol Cancer Res Volume: 10巻 Pages: 3-10
  • Peer Reviewed
• [Journal Article] MiR-126 Acts as a Tumor Suppressor in Pancreatic Cancer Cells via the Regulation of ADAM9 (2012)
  • Author(s): Hamada S, Satoh K, Fujibuchi W, Hirota M, Kanno A, Unno J, Masamune A, Kikuta K, et al
  • Journal Title: Mol Cancer Res Volume: 10 Pages: 3-10
  • Peer Reviewed
• [Journal Article] The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG2 (2012)
  • Author(s): Hamada S, Satoh K, Hirota M, Kanno A, Umino J, Ito H, Masamune A, Kikuta K, Kume K, Shimosegawa T
  • Journal Title: J Cell Physiol Volume: 227(2) Issue: 2 Pages: 729-738
  • DOI: 10.1002/jcp.22781
  • Peer Reviewed
• [Journal Article] Perfusion computed tomography findings of autoimmune pancreatitis. (2011)
  • Author(s): Hirota M, Tsuda M, Tsuji Y, Kanno A, Kikuta K, et al.
  • Journal Title: Pancreas Volume: 40巻 Pages: 1295-1301
  • Peer Reviewed
• [Journal Article] Long-period pancreatic stenting for painful chronic calcified pancreatitis required higher medical costs and frequent hospitalizations with surgery. (2011)
  • Author(s): Hirota M, Asakura T, Kanno A, Kikuta K, et al.
  • Journal Title: Pancreas Volume: 40巻 Pages: 946-950
  • Peer Reviewed
• [Journal Article] Nationwide epidemiological survey of acute pancreatitis in Japan (2011)
  • Author(s): Satoh K, Shimosegawa T, Masamune A, Hirota M, Kikuta K, et al.
  • Journal Title: Pancreas Volume: 40巻 Pages: 503-507
  • Peer Reviewed
• [Journal Article] Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells (2011)
  • Author(s): Kikuta K, Masamune A, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 403巻 Pages: 380-384
  • Peer Reviewed
• [Journal Article] Calcium-binding protein S100P is a novel diagnostic marker of cholangiocarcinoms (2011)
  • Author(s): Hamada S, Satoh K, Hirota M, Kanno A, Ishida K, Umino J, Ito H, Kikuta K, et al.
  • Journal Title: Cancer Sci Volume: 102巻 Pages: 150-156
  • Peer Reviewed
• [Journal Article] Nationwide epidemiological survey of acute pancreatitis in Japan (2011)
  • Author(s): Satoh K, Shimosegawa T, Masamune A, Hirota M, Kikuta K, et al
  • Journal Title: Pancreas Volume: 40 Pages: 503-507
  • Peer Reviewed
• [Journal Article] Long-period pancreatic stenting for painful chronic calcified pancreatitis required higher medical costs and frequent hospitalizations with surgery (2011)
  • Author(s): Hirota M, Asakura T, Kanno A, Kikuta K, et al
  • Journal Title: Pancreas Volume: 40 Pages: 946-950
  • Peer Reviewed
• [Journal Article] Perfusion computed tomography findings of autoimmune pancreatitis (2011)
  • Author(s): Hirota M, Tsuda M, Tsuji Y, Kanno A, Kikuta K, et al
  • Journal Title: Pancreas Volume: 40 Pages: 1295-1301
  • Peer Reviewed
• [Journal Article] Calcium-binding protein S100P is a novel diagnostic marker of cholangiocarcinoms (2011)
  • Author(s): Hamada S, Satoh K, et al.
  • Journal Title: Cancer Sci Volume: 102 Pages: 150-6
  • Peer Reviewed
• [Journal Article] Nuclear expression of interleukin-33 in pancreatic stellate cells (2010)
  • Author(s): Masamune A, Watanabe T, Kikuta K, et al.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 299巻 Pages: 821-832
  • Peer Reviewed
• [Journal Article] Nuclear expression of interleukin-33 in pancreatic stellate cells (2010)
  • Author(s): Masamune A, Watanabe T, Kikuto K, et al.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 299
  • Peer Reviewed
• [Presentation] Pancreatic stellate cells induce apoptosis of islet cells.-Possible mechanism of pancreatic diabetes (2011)
  • Author(s): Kazuhiro Kikuta, Atsushi Masamune, Noriaki Suzuki, Tooru Shimosegawa
  • Organizer: The 6_<th> International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-21
• [Presentation] 膵島細胞のインスリン発現、アポトーシス誘導における膵星細胞の関与に関する解析 (2011)
  • Author(s): 菊田和宏、正宗淳、下瀬川徹
  • Organizer: 第53回日本消化器病学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-21
• [Presentation] Pancreatic stellate cells induce apoptosis of islet cells.-Possible mechanism of pancreatic diabetes- (2011)
  • Author(s): Kazuhiro Kikuta, Atsushi Masamune, Noriaki Suzuki, Tooru Shimosegawa
  • Organizer: The 6^<th> International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-10-21
• [Presentation] 膵星細胞は膵島細胞のインスリン発現を抑制しアポトーシスを誘導する (2011)
  • Author(s): 菊田和宏、正宗淳、下瀬川徹
  • Organizer: 第42回日本膵臓学会大会
  • Place of Presentation: 弘前
  • Year and Date: 2011-07-29
• [Presentation] Pancreatic stellate cells induce epithelial-mesenchymal transition and proliferation of pancreatic cancer cells (2010)
  • Author(s): Kazuhiro Kikuta, Atsushi Masamune, et al.
  • Organizer: 第14回国際膵臓学会・第41回日本膵臓学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2010-07-11