| Project/Area Number |
22790636
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
YANO Masahiko 新潟大学, 医歯学総合病院, 医員 (70529693)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 肝炎ウイルス / 新規ウイルス抑制機構 / 肝細胞内シグナル伝達 / C型肝炎ウイルス / B型肝炎ウイルスX蛋白質 / 酸化ストレス / ウイルス複製抑制機構 / p21細胞内局在 / シグナル伝達 / ウイルス複製制御機構 |
|---|
| Research Abstract |
In this study, to find the novel inhibitory mechanism against hepatitis viral replication in hepatocytes, the mouse and cultured cells expressing the protein of hepatitis B virus were utilized. As a result, it was suggested that the controlled induction of nuclear cyclin-dependent kinase inhibitor(p21), one of the anti-cancerous molecules, might exhibit the anti-hepatocarcinogenic and further anti-viral effects. The current result could contribute to the development of novel therapy against intractable viral hepatitis.
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