Research for new drug which targets EGFR at serine residues
Project/Area Number |
22790639
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
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Research Institution | Gifu University |
Principal Investigator |
ADACHI Seiji 岐阜大学, 医学系研究科, 非常勤講師 (50467205)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | EGFR / EGF / 紫外線 / p38 MAPK / セリン残基 / リン酸化 / 脱感作 / 内在化 / Ser1046/1047 / p38MAPK / UV / HSP90 |
Research Abstract |
We have previously reported that EGCG as well as HSP90 inhibitors or anisomycin cause downregulation of the EGFR via phosphorylation at Ser1046/1047 through p38 MAPK in human cancer cells. Moreover, we demonstrated that short-wave length ultra-violet(UV-C) irradiation induces the removal of EGFR from cell surface that can protect colon cancer cells from oncogenic stimulation of EGF, resulting in cell cycle arrest. Hence, our findings suggest that EGFR at Ser1046/1047 could be a novel molecular target against human colon cancers.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Use of Samples from Endoscopic, Ultrasound-Guided, 19-Gauge, Fine-Needle Aspiration in Diagnosis of Autoimmune Pancreatitis2012
Author(s)
Iwashita T, Yasuda I, Doi S, Ando N, Nakashima M, Adachi S, Hirose Y, Mukai T, Iwata K, Tomita E, Itoi T, Moriwaki H.
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Journal Title
Clin Gastroenterol Hepatol
Volume: 10
Pages: 316-22
Related Report
Peer Reviewed
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[Journal Article] Endoscopic ultrasound-guided fine needle aspiration biopsy for diagnosis of lymphoproliferative disorders : Feasibility of immunohistological, flow cytometric, and cytogenetic assessments2012
Author(s)
Yasuda I, Goto N, Tsurumi H, Nakashima M, Doi S, Iwashita T, Kanemura N, Kasahara S, Adachi S, Hara T, Shimizu M, Takami T, Moriwaki H.
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Journal Title
Am J Gastroenterol
Volume: 107
Pages: 397-404
Related Report
Peer Reviewed
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[Journal Article] Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells2011
Author(s)
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Itani M, Yoshioka T, Matsushima-Nishiwaki R, Hirose Y, Kozawa O, Moriwaki H.
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Journal Title
Cancer Lett
Volume: 27
Pages: 218-25
Related Report
Peer Reviewed
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[Journal Article] Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor2011
Author(s)
Adachi S, Yasuda I, Nakashima M, Yamauchi T, Kawaguchi J, Shimizu M, Itani M, Nakamura M, Nishii Y, Yoshioka T, Hirose Y, Okano Y, Moriwaki H, Kozawa O.
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Journal Title
J Biol Chem
Volume: 286
Pages: 26178-26187
Related Report
Peer Reviewed
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[Journal Article] UV-C irradiation induces downregulation of EGF receptor via phosphorylation at serine 1046/1047 in human pancreatic cancer cells2011
Author(s)
Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Nishii Y, Yoshioka T, Okano Y, Hirose Y, Kozawa O, Moriwaki H.
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Journal Title
Radiation Res
Volume: 176
Pages: 565-74
Related Report
Peer Reviewed
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[Journal Article] Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells2011
Author(s)
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Hanamatsu T, Yoshioka T, Okano Y, Hirose Y, Kozawa O, Moriwaki H.
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Journal Title
Mol Cancer
Volume: 10
Pages: 79-79
Related Report
Peer Reviewed
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[Journal Article] EUS-FNA of Lesions near the Aortoiliac Bifurcation via an Upper Gastrointestinal Approach2011
Author(s)
Doi S, Yasuda I, Nakashima M, Kawaguchi J, Yamauchi T, Iwashita T, Toda K, Adachi S, Shimizu M, Tsurumi H, Moriwaki H.
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Journal Title
J Gastroenterol Hepatol
Volume: 26
Pages: 1717-20
Related Report
Peer Reviewed
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