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Chemoprevention for gastric carcinogenesis by inhibition of renin-angiotensin system

Research Project

Project/Area Number 22790640
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

SUGIMOTO Mitsushige  浜松医科大学, 医学部・附属病院, 助教 (80397398)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords上部消化管学(食道、胃、十二指腸) / 胃癌 / ヘリコバクター / レニン-アンジオテンシン / 化学発癌予防 / スナネズミ
Research Abstract

Gastric mucosal AT1R and AT2R mRNAs/β-actin mRNA ratios were approximately zero in H. pylori uninfected animals throughout the 12-month observation period. On the other hand, both AT1R and AT2R mRNA ratios in animals treated with wild-type H. pylori gradually increased during the time course. The median MNCs infiltration score was significantly correlated with AT1R and AT2R levels. The cagA-and oipA-knockout strain induced significantly milder inflammation compared with the wild-type. AT1R and AT2R mRNA levels were significantly higher in gerbils that developed gastric ulcers than in gerbils without gastric ulcer, suggested that RAS inhibitors may have chemoprevention for gastric carcinogenesis.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] The role of the renin-angiotensin system in gastric oncogenesis2012

    • Author(s)
      Sugimoto M, Yamaoka Y, Shirai N, Furuta T
    • Journal Title

      J Gastroenterol Hepetol

      Volume: 27 Pages: 442-451

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Gastric mucosal expression of angiotensin II type 1 and type 2 receptor mRNA in Helicobacter pylori-infected Mongolian gerbils2011

    • Author(s)
      Sugimoto M, Ohno T, Graham DY, Yamaoka Y
    • Journal Title

      J Gasroenterology

      Volume: 36 Pages: 1177-1186

    • Related Report
      2011 Final Research Report
  • [Journal Article] Expression of angiotensin II type 1 and type 2 receptor mRNAs in the gastric mucosa of Helicobacter pylori-infected Mongolian gerbils2011

    • Author(s)
      Sugimoto M, Ohno T, Yamaoka Y
    • Journal Title

      J Gastroenterol

      Volume: 46 Issue: 10 Pages: 1177-86

    • DOI

      10.1007/s00535-011-0433-7

    • NAID

      10030294368

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] H. pylori感染におけるレニンーアンギオテンシンシステムの関与2010

    • Author(s)
      杉本光繁
    • Organizer
      ヘリコバクター学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] H.pylori感染におけるレニンーアンギオテンシンシステムの関与2010

    • Author(s)
      杉本光繁
    • Organizer
      ヘリコバクター学会 学術集会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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