| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Nardilysin(NRDc) has been reported to promote ectodomain shedding of the precursor forms of various growth factors in cooperation with ADAM proteins such as ADAM17. NRDc expression was frequently elevated in the cancer epithelium of gastric cancer tissues. After knockdown of NRDc expression, gastric cancer cell growth was suppressed. In gastric cancer cells, NRDc promotes ectodomain shedding of pro-TNF-alpha, leading to the upregulated transcription of various cytokines such as IL-6. As a result, NRDc maintains the expressions of growth-related genes via activated STAT3.
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