Pathophysiological analysis and clinical application of oligosaccharide alterations in inflammatory bowel disease
| Project/Area Number |
22790643
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 下部消化管学(小腸、大腸) / 炎症性腸疾患 / 糖鎖 / IgG / B細胞 / インフリキシマブ / B4GaｌT / B4GalT |
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| Research Abstract |
Focused on the increase in agalactosyl IgG in patients with inflammatory bowel disease (IBD), the pathophysiological roles of oligosaccharide alterations on immunoglobulin and immune cells were investigated using colitis model. For clinical application, the relationship between oligosaccharide alterations and patient characteristics in IBD patients were also clarified.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis2012
Author(s)
Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T
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Journal Title
Inflamm Bowel Dis
Volume: (in press)
Issue: 11
Pages: 2169-79
DOI
Related Report
Peer Reviewed
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