Search for biomarkers against colorectal cancer by the mass spectrometry-based metabolome analysis
| Project/Area Number |
22790645
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kobe University |
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Principal Investigator |
OKUNO Tatsuya 神戸大学, 医学部附属病院, 特定助教 (50464269)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | メタボロミクス / バイオマーカー / 早期診断 / がん / 質量分析 / 大腸癌 |
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| Research Abstract |
In the cells with pathological conditions, a variety of metabolites are produced via the secretion of disease-related proteins and the protein degradation by proteases. However, the comprehensive study on these disease-specific low-molecular weight metabolites has not obtained the good and interesting results yet because of various problems. Therefore, the experiments to comprehensively analyze the low-molecular weight metabolites derived from colorectal carcinomas was designed, and the novel cancer-specific biomarkers was searched. In addition, it was investigated whether the identified biomarkers can be actually used in the clinical practice.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer2012
Author(s)
Atsuki Ikeda, Shin Nishiumi, Masakazu Shinohara, Tomoo Yoshie, Naoya Hatano, Takuya Okuno, Takeshi Bamba, Eiichiro Fukusaki, Tadaomi Takenawa, Takeshi Azuma, Masaru Yoshida.
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Journal Title
Biomedical Chromatography
Volume: 26(5)
Pages: 548-58
Related Report
Peer Reviewed
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