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Search for biomarkers against colorectal cancer by the mass spectrometry-based metabolome analysis

Research Project

Project/Area Number 22790645
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKobe University

Principal Investigator

OKUNO Tatsuya  神戸大学, 医学部附属病院, 特定助教 (50464269)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsメタボロミクス / バイオマーカー / 早期診断 / がん / 質量分析 / 大腸癌
Research Abstract

In the cells with pathological conditions, a variety of metabolites are produced via the secretion of disease-related proteins and the protein degradation by proteases. However, the comprehensive study on these disease-specific low-molecular weight metabolites has not obtained the good and interesting results yet because of various problems. Therefore, the experiments to comprehensively analyze the low-molecular weight metabolites derived from colorectal carcinomas was designed, and the novel cancer-specific biomarkers was searched. In addition, it was investigated whether the identified biomarkers can be actually used in the clinical practice.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer2012

    • Author(s)
      Atsuki Ikeda, Shin Nishiumi, Masakazu Shinohara, Tomoo Yoshie, Naoya Hatano, Takuya Okuno, Takeshi Bamba, Eiichiro Fukusaki, Tadaomi Takenawa, Takeshi Azuma, Masaru Yoshida.
    • Journal Title

      Biomedical Chromatography

      Volume: 26(5) Pages: 548-58

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer2012

    • Author(s)
      Atsuki Ikeda
    • Journal Title

      Biomedical chromatography

      Volume: (印刷中)(掲載確定) Issue: 5 Pages: 548-558

    • DOI

      10.1002/bmc.1671

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNFRSF1B A1466G genotype is predictive of clinical efficacy after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.2010

    • Author(s)
      Kuwahara A, et al.
    • Journal Title

      J Exp Clin Cancer Res.

      Volume: 29 Pages: 100-105

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 当院における後期高齢者食道癌の内科的及び外科的治療の成績について2010

    • Author(s)
      池田篤紀
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 進行食道癌放射線化学療法後の残存リンパ節に対しsalvage切除手術を試みた一例2010

    • Author(s)
      奥野達哉
    • Organizer
      第64回日本食道学会
    • Place of Presentation
      石橋文化ホール(福岡県)
    • Year and Date
      2010-09-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当院における食道癌術後局所再発症例に対するSalvage化学放射線療法(CRT)の治療成績について2010

    • Author(s)
      奥野達哉
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟県民会館(新潟県)
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/gi/index.htm

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/gi/index.htm

    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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