Development of the novel liver repair therapy with interaction between bone marrow stem cells and macrophages

• Project/Area Number: 22790647
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Yamaguchi University
• Principal Investigator: ISHIKAWA Tsuyoshi 山口大学, 大学院・医学系研究科, 助教 (20569305)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肝再生 / 肝線維化 / 骨髄細胞 / マクロファージ / 炎症細胞

Research Abstract

Macrophages which are infiltrated into the liver after bone marrow stem cell transplantation to cirrhotic mice are mainly originated from recipients and stromal derived factor 1/ CXCR4 signaling is closely related to the migration of macrophages from bone marrow to the liver. And also, matrix metalloproteinase 9 expressed by macrophages can reduce collagen fiber in the liver. We will develop the novel liver repair therapy to improve hepatic fibrosis with interaction between bone marrow stem cells and macrophages.

Research Products

• [Journal Article] Hepatocyte growth factor/ c-met signaling is required for stem cell-mediated liver regeneration in mice (2012)
  • Author(s): Ishikawa T, Factor VM, Marquardt JU, Raggi C, Seo D, Kitade M, Conner EA Thorgeirsson SS
  • Journal Title: Hepatology 2012 Apr Volume: 55(4) Pages: 1215-26
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor/c-met signaling is required for stem-cell- (2012)
  • Author(s): Tsuyoshi Ishikawa
  • Journal Title: Hepatology Volume: 55(4) Issue: 4 Pages: 1215-1226
  • DOI: 10.1002/hep.24796
  • Peer Reviewed
• [Presentation] Ovalcellの活性化に伴う肝再生・修復過程におけるHGF/ c-Metシグナリングの役割 (2010)
  • Author(s): 石川剛
  • Organizer: JDDW2010
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] Oval cellの活性化に伴う肝再生・修復過程におけるHGF/c-Metシグナリングの役割 (2010)
  • Author(s): 石川剛
  • Organizer: JDDW 2010
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] HGF/ c-Metシグナリングはovalcell由来肝再生に必須である (2010)
  • Author(s): 石川剛
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形メトロポリタン山形
  • Year and Date: 2010-05-28
• [Presentation] HGF/c-Metシグナリングはoval cell由来肝再生に必須である (2010)
  • Author(s): 石川剛
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形 メトロポリタン山形
  • Year and Date: 2010-05-28
• [Presentation] HGF/ c-Metシグナリングはovalcell由来肝再生に必須である (2010)
  • Author(s): 石川剛
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟新潟県民会館
  • Year and Date: 2010-04-23
• [Presentation] HGF/c-Metシグナリングはoval cell由来肝再生に必須である (2010)
  • Author(s): 石川剛
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟 新潟県民会館
  • Year and Date: 2010-04-23