| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We reported that renin-angiotensin system is important for progression of hepatic fibrosis in NASH. Angiotensin type 1 receptor blocker(ARB) attenuates progression of hepatic fibrosis in NASH by inhibition of angiotensin type 1 receptor(AT1) activity. We clarified, in this study, that attenuation of AT1 receptor activity by ARB was not related to the inhibition of mechanical activation of AT1 receptor unlike heart muscle cells, and inhibition of the signal transduction of AGE-RAGE system in hepatic stellate cells by ARB was central role for the attenuation of development of NASH.
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