Diagnostic systems of diffuse type gastric cancer using by epigenomic approach
| Project/Area Number |
22790655
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 癌 / メチル化 / マイクロアレイ / 遺伝子診断 / 癌予防 / 胃癌 / リスク予測 |
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| Research Abstract |
Using methylated-CpG island amplification coupled with CpG island microarray(MCAM) analysis, RASGRF1 methylation was significantly elevated in gastric mucosafrom patients with either intestinal or diffuse type gastric cancer (GC). Our datasuggest that RASGRF1 methylation could be a useful biomarker with which to identifyindividuals at high risk for GC.We evaluated the clinical utility of DNA methylation as a biomarker ofmetachronous GC risk by performing a prospective study. Our results suggest thatmethylation of miR-34b/c in background gastric mucosae may be a useful marker topredict metachronous GC risk.
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Report
(4 results)
Research Products
(27 results)
