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A new molecular target therapy for gastric can cer targeting nuclear translocation of the CTF of EGFR ligands

Research Project

Project/Area Number 22790665
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionNagoya City University

Principal Investigator

SHIMURA Takaya  名古屋市立大学, 大学院・医学研究科, 助教 (90405192)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords胃癌 / 分子標的治療 / HB-EGF / Amphiregulin / EGFR
Research Abstract

HB-EGF-CTF nuclear translocation increased motility and invasion of gastric cancer cell. The nuclear immunoreactivity of HB-EGF-CTF was significantly increased in stage pT3/4 tumors compared with pT1/2 tumors in human gastric cancer. These results suggested that HB-EGF-CTF nuclear translocation induce gastric cancer invasion(Shimura T, et al. BMC Cancer 2012, in press).
AR nuclear translocation significantly induced chemoresistance in vitro and in vivo, and AR-nuclear staining was extracted as a significant poor prognostic factor in human gastric cancer. As these results, AR nuclear translocation reduces chemosensitivity to anti-cancer drugs and would be associated with poor prognosis in human gastric cancer(Yoshida M, Shimura T, et al. Cancer Sci 2012).

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 3 results) Presentation (17 results) Remarks (1 results)

  • [Journal Article] Nuclear translocation of the cytoplasmic domain of HB-EGF induces gastric cancer invasion2012

    • Author(s)
      Shimura T, Yoshida M, Fukuda S, Ebi M, Hirata Y, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Higashiyama S, Joh T
    • Journal Title

      BMC cancer

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Journal Article] The relationship between antitumor effects and relative dose intensity of S-1 plus cisplatin treatment for metastatic gastric cancer2012

    • Author(s)
      Kitagawa M, Shimura T, Yamada T, Ebi M, Hirata Y, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Joh T
    • Journal Title

      Anticancer Res

      Volume: 32(5) Pages: 1763-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer2012

    • Author(s)
      Yoshida M, Shimura T, Fukuda S, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Nakazawa T, Higashiyama S, Joh T
    • Journal Title

      Cancer Sci

      Volume: 103(4) Pages: 708-15

    • Related Report
      2011 Final Research Report
  • [Journal Article] The impact of cross-resistance between paclitaxel and docetaxel for metastatic gastric cancer2012

    • Author(s)
      Shimura T, Kitagawa M, Yamada T, Yoshida M, Ebi M, Hirata Y, Mizushima T, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Joh T
    • Journal Title

      Onkologie

      Volume: 35(4) Pages: 176-83

    • Related Report
      2011 Final Research Report
  • [Journal Article] C-reactive protein is a potential poor prognostic factor for metastatic gastric cancer2012

    • Author(s)
      Shimura T, Kitagawa M, Yamada T, Ebi M, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Joh T
    • Journal Title

      Anticancer Res

      Volume: 32(2) Pages: 491-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer2012

    • Author(s)
      Yoshida Michihiro
    • Journal Title

      Cancer Science

      Volume: 103 Issue: 4 Pages: 708-715

    • DOI

      10.1111/j.1349-7006.2012.02204.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of cross-resistance between paclitaxel and docetaxel for metastatic gastric cancer2012

    • Author(s)
      Shimura T, et al
    • Journal Title

      Onkologie

      Volume: 35 Issue: 4 Pages: 176-183

    • DOI

      10.1159/000337400

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-reactive protein is a potential poor prognostic factor for metastatic srastric cancer2012

    • Author(s)
      Shimura T, et al
    • Journal Title

      Anticancer Research

      Volume: 32 Pages: 491-496

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metastatic Colorectal Cancer with Severe Liver Dysfunction Successfully Treated Using FOLFOX Therapy2011

    • Author(s)
      Shimura T, Kataoka H, Joh T, (他8名, 1番目)
    • Journal Title

      J Gastrointest Cancer

      Volume: 42(1) Pages: 68-72

    • Related Report
      2011 Final Research Report
  • [Journal Article] TGFβinduces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells2010

    • Author(s)
      Ebi M, Kataoka H, Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 402(3) Pages: 449-54

    • Related Report
      2011 Final Research Report
  • [Journal Article] Clinical features of interstitial lung disease induced by standard chemotherapy(FOLFOX or FOLFIRI) for colorectal cancer2010

    • Author(s)
      Shimura T, Fuse N, Yoshino T, Minashi K, Tahara M, Doi T, Joh T, Ohtsu A
    • Journal Title

      Ann Oncol

      Volume: 21(10) Pages: 2005-10

    • Related Report
      2011 Final Research Report
  • [Journal Article] Intranuclear translocation signaling of HB-EGF carboxy-terminal fragment and mucosal defense through cell proliferation and migration in digestive tracts2010

    • Author(s)
      Tanida S, Kataoka H, Mizoshita T, Shimura T, Kamiya T, Joh T
    • Journal Title

      Digestion

      Volume: 82(3) Pages: 145-9

    • Related Report
      2011 Final Research Report
  • [Presentation] Amphiregulin nuclear translocation might cause poor prognosis due to chemotherapeutic resistance in gastric cancer2011

    • Author(s)
      吉田道弘, 志村貴也, 他
    • Organizer
      第22回日本消化器癌発生学会総会
    • Place of Presentation
      ホテルニューオータニ佐賀(佐賀県)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃癌治療におけるパクリタキセルとドセタキセルの交差耐性の検討2011

    • Author(s)
      志村貴也.(1番目)北川美香, 吉田道弘, 山田智則, 海老正秀, 水島隆史, 平田慶和, 村上賢治, 片岡洋望, 城卓志
    • Organizer
      53th JDDW
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Amphiregulin nuclear translocation might cause poor prognosis due to chemotherapeutic resistance in gastric cancer2011

    • Author(s)
      志村貴也
    • Organizer
      第53回JDDW
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] HB-EGF-CTF nuclear translocation induces gastric cancer invasion2011

    • Author(s)
      Shimura T, Yoshida M, Fukuda S, Mizoshita T, Kataoka H, Higashiyama S, Joh T, .(1番目)
    • Organizer
      70^<th> Japan Cancer Association
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-10-05
    • Related Report
      2011 Final Research Report
  • [Presentation] HB-EGF-CTF nuclear translocation induces gastric cancer invasion2011

    • Author(s)
      Shimura T, et al
    • Organizer
      70^<th> Japan Cancer Association Meeting
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Amphiregulin nuclear translocation might cause poor prognosis due to chemotherapeutic resistance in gastric cancer2011

    • Author(s)
      Yoshida M, Shimura T, Fukuda S, Mizoshita T, Kataoka H, Higashiyama S, Joh T.(2番目)
    • Organizer
      70^<th> Japan Cancer Association
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Amphiregulin nuclear translocation might cause poor prognosis due to chemotherapeutic resistance in gastric cancer2011

    • Author(s)
      Yoshida M, Shimura T, et al
    • Organizer
      70^<th> Japan Cancer Association Meeting
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] The impact of cross-resistance between paclitaxel and docetaxel for gastric cancer2011

    • Author(s)
      Shimura T, Kitagawa M, Tomonori Yamada, Michihiro Yoshida, Masahide Ebi, Yoshikazu Hirata, Takashi Mizushima, Tsutomu Mizoshita, Satoshi Tanida, Hiromi Kataoka, Takeshi Kamiya, Joh T.(1番目)
    • Organizer
      9^<th> JSMO
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-07-22
    • Related Report
      2011 Final Research Report
  • [Presentation] The impact of cross-resistance between paclilaxel and docetaxel for gastric cancer2011

    • Author(s)
      志村貴也
    • Organizer
      9^<th> JSMO Meeting
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃癌におけるamphiregulin核移行と抗癌剤耐性2011

    • Author(s)
      吉田道弘, 志村貴也, 他
    • Organizer
      第97回消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] HB-EGF-CTF nuclear translocation induces gastric cancer invasion2010

    • Author(s)
      Shimura T, Yoshida M, Tanaka M, Kataoka H, Higashiyama S, Joh T, et al, (1番目)
    • Organizer
      35th ESMO
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2010-10-11
    • Related Report
      2011 Final Research Report
  • [Presentation] HB-EGF-CTF nuclear translocation induces gastric cancer invasion.2010

    • Author(s)
      志村貴也
    • Organizer
      35th ESMO
    • Place of Presentation
      イタリア、ミラノ(Fieramilano city)
    • Year and Date
      2010-10-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Amphiregulin nuclear translocation might reduce chemosensitivity in gastric cancer.2010

    • Author(s)
      吉田道弘
    • Organizer
      35th ESMO
    • Place of Presentation
      イタリア、ミラノ(Fieramilano city)
    • Year and Date
      2010-10-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Amphiregulin nuclear translocation might reduce chemosensitivity in gastric cancer2010

    • Author(s)
      Yoshida M, Shimura T, Higashiyama S, Kataoka H, Joh T, et al.(2番目)
    • Organizer
      35th ESMO
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2010-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌の新規分子標的としてのHB-EGF-CTFシグナルの意義2010

    • Author(s)
      志村貴也.(1番目)、吉田道弘、福田信治、東山繁樹、溝下勤、久保田英嗣、谷田諭史、片岡洋望、神谷武、城卓志
    • Organizer
      第42回胃病態機能研究会
    • Place of Presentation
      札幌
    • Year and Date
      2010-08-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌の新規分子標的としてのHB-EGF-CTFシグナルの意義2010

    • Author(s)
      志村貴也
    • Organizer
      第42回胃病態機能研究会
    • Place of Presentation
      札幌(札幌プリンスホテル国際館パミール)
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌におけるamphiregulin核移行の意義の検討2010

    • Author(s)
      吉田道弘
    • Organizer
      第29回消化器病態生理勉強会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Remarks] 名古屋市立大学大学院医学研究科消化器代謝内科学ホームページ業績集

    • URL

      http://www.ncu-shotai.ac/index.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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