| Project/Area Number |
22790665
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SHIMURA Takaya 名古屋市立大学, 大学院・医学研究科, 助教 (90405192)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 胃癌 / 分子標的治療 / HB-EGF / Amphiregulin / EGFR |
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| Research Abstract |
HB-EGF-CTF nuclear translocation increased motility and invasion of gastric cancer cell. The nuclear immunoreactivity of HB-EGF-CTF was significantly increased in stage pT3/4 tumors compared with pT1/2 tumors in human gastric cancer. These results suggested that HB-EGF-CTF nuclear translocation induce gastric cancer invasion(Shimura T, et al. BMC Cancer 2012, in press).
AR nuclear translocation significantly induced chemoresistance in vitro and in vivo, and AR-nuclear staining was extracted as a significant poor prognostic factor in human gastric cancer. As these results, AR nuclear translocation reduces chemosensitivity to anti-cancer drugs and would be associated with poor prognosis in human gastric cancer(Yoshida M, Shimura T, et al. Cancer Sci 2012).
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