Competition between colitogenic Th1 and Th17 cells as a new concept of IBD pathogenesis and new therapeutic target.
| Project/Area Number |
22790667
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
MIKAMI Yohei 慶應義塾大学, 医学部, 研究員(非常勤) (80528662)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 炎症性腸疾患 / インターロイキン17 / インターフェロンガンマ / クローナルコンペティション |
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| Research Abstract |
In this study, we showed that the interaction between Th17 cells and Th1 cells contribute to altering disease phenotypes. We have also demonstrated that Th17 and Th17/Th1 cells become colitogenic alternative Th1 cells via Th17, Th17/Th1, and Th1-like cells, independently of classical Th1 cells. We have also established that regulatory T cells suppress this pathway, resulting in accumulation of Th17 and Th17/Th1 cells. This alternative pathway, generating colitogenic Th1 cells, could be a new therapeutic target of Inflammatory bowel diseases(IBD).
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells2011
Author(s)
Sujino T, Kanai T, Ono Y, Mikami Y, Hayashi A, Doi T, Matsuoka K, Hisamatsu T, Takaishi H, Ogata H, Yoshimura A, Littman DR, Hibi T
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Journal Title
Gastroenterology
Volume: 141(3)
Pages: 1014-23
Related Report
Peer Reviewed
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[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis2010
Author(s)
Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T
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Journal Title
Eur J Immunol
Volume: 40(9)
Pages: 2409-22
Related Report
Peer Reviewed
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[Journal Article] MyD88-dependent pathway accelerates the liver damage of Concanavalin A-induced hepatitis2010
Author(s)
Ojiro K, Ebinuma H, Nakamoto N, Wakabayashi K, Mikami Y, Ono Y, Po-Sung C, Usui S, Umeda R, Takaishi H, Yamagishi Y, Saito H, Kanai T, Hibi T
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Journal Title
Biochem Biophys Res Commun
Volume: 399(4)
Pages: 744-9
Related Report
Peer Reviewed
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[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010
Author(s)
Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T.
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Journal Title
Eur J Immunol.
Volume: 40(9)
Pages: 2409-22
Related Report
Peer Reviewed
-
[Journal Article] MyD88-dependent pathway accelerates the liver damage of Concanavalin A-induced hepatitis.2010
Author(s)
Ojiro K, Ebinuma H, Nakamoto N, Wakabayashi K, Mikami Y, Ono Y, Po-Sung C, Usui S, Umeda R, Takaishi H, Yamagishi Y, Saito H, Kanai T, Hibi T.
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Journal Title
Biochem Biophys Res Commun.
Volume: 399(4)
Pages: 744-9
Related Report
Peer Reviewed
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