The Association between CDX2 and tyrosine kinases in chemotherapy refractory colorectal cancer and its mechanism.
| Project/Area Number |
22790670
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
LYNCH John P University of Pennsylvania, epartment of Medicine, Division of Gastroenterology, Associate Professor of Medicine
AZUMA Toshifumi 東京歯科大学, 歯学部, 教授 (00222612)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | CDX2強制発現大腸癌細胞株 / 細胞接着 / Rac1 / IGF / c-MET / sp細胞 / CDX2強制発現大腸癌株 / ShRNA,siRNA / 免疫染色 / ShRNA, SiRNA / caveolin1 / 上皮間葉転換 / ShRNA / EGF |
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| Research Abstract |
Using MIGR1- control and MIGR-Cdx2-infected Colo205 cells, the phosphorylation states of several receptor tyrosine kinases and the expression of cell adhesion marker were analyzed. Secondly, in Colo 205 cells, Cdx2 increased caveolin in mRNA and protein l
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Report
(4 results)
Research Products
(9 results)
