Identification of a biomarker of the epithelial stem cell and analysis of the regenerative and carcinogenic mechanisms of digestive tract
| Project/Area Number |
22790676
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
FUKUI Toshiro 関西医科大学, 医学部, 講師 (60402905)
|
|---|
| Research Collaborator |
KISHIMOTO Masanobu 関西医科大学, 医学部, 大学院生
TKAHASHI Yu 関西医科大学, 医学部, 大学院生
SUZUKI Ryo 関西医科大学, 医学部, 大学院生
OKAZAKI Kazuichi 関西医科大学, 医学部, 教授 (70145126)
MATSUZAKI Koichi 関西医科大学, 医学部, 准教授 (70278638)
UCHIDA Kazushige 関西医科大学, 医学部, 講師 (40411516)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 上部消化管学(食道、胃、十二指腸) / 消化管上皮幹細胞 / 消化管粘膜再生 / 腫瘍 / 癌幹細胞 / 発生・分化 / シグナル伝達 / 上皮幹細胞 / 細菌 / 癌 |
|---|
| Research Abstract |
We have identified the significant expression of pSmad2/3L-Thr in specific epithelial cells of the murine stomach, small intestine, and colon. We have suggested these cells to be epithelial stem cells in the G0 phase of the cell cycle before active proliferation.
|
Report
(4 results)
Research Products
(14 results)
