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Novel therapeutic approaches of intestinal stenosis focused on myofibroblasts

Research Project

Project/Area Number 22790677
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionFukuoka University

Principal Investigator

KURAHARA Lin (HAI Lin)  福岡大学, 医学部, 講師 (00341438)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords下部消化管学(小腸、大腸) / 組織線維化 / 炎症性腸疾患 / 線維化狭窄 / 筋線維芽細胞 / TRPC4 / TRPC6 / カルシウム / TGF-β1 / TGFβ1 / コラーゲン / TNFα / PGE2 / 腸管狭窄 / TRPC1 / Ca^<2+> / NF-κB / 線維化
Research Abstract

TRPC4 and C6 channels may play non-trivial roles in myofibroblast transformation/differentiation, thereby promoting fibrogenesis in the colon. Our results also suggested that myfibroblast signaling pathways regulating interleukin production, which seem associated with the phosphorylation of Smad2, Erk1/2, and p38 MAPK as well as TRPC6-mediated Ca2+ influx. TRPC4 and TRPC6 could be a promising target in treating fibrotic and inflammatory bowel diseases.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (18 results)

  • [Journal Article] Critical role of TRPC1-mediated Ca2+ entry in decidualization of human endometrial stromal cells2012

    • Author(s)
      Yasuhiro Kawarabayashi, Lin Hai, Akira Honda, Shinji Horiuchi, Hiroshi Tsujioka, Jun Ichikawa, Ryuji Inoue
    • Journal Title

      Molecular Endocrinology

      Volume: 26(5) Issue: 5 Pages: 846-858

    • DOI

      10.1210/me.2011-1259

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Counteracting effect of TRPC1-associated Ca^<2+> influx on TNFα-induced COX-2-dependent prostaglandin E_2 production in human colonic myofibroblasts2011

    • Author(s)
      Hai L, Kawarabayashi Y, Imai Y, Honda A, Inoue R.
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology

      Volume: 301(2) Issue: 2 Pages: G356-G367

    • DOI

      10.1152/ajpgi.00354.2010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Counteracting effect of TRPC 1-asscoiated Ca^<2+> influx on TNF α induced COX-2-dependent prostaglandin E_2 production in human colonic myofibroblasts2011

    • Author(s)
      Lin Hai, Yasuhiro Kawarabayashi, Yuko Imai, Akira Honda, Ryuji Inoue
    • Journal Title

      AMERICAN JOURNAL OF PHYSIOLOGY -GASTROINTESTINAL AND LIVER PHYSIOLOGY

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Intestinal myofibroblast TRPC4, C6 channels confer fibrogenic potential for human stenosis2013

    • Author(s)
      Lin-Hai Kurahara, Miho Sumiyoshi, Ryuji Inoue
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Involvement of TRPC6 channel in TGF β 1/SMAD/MAPK/PI3K signaling in human intestinal myofibroblast2013

    • Author(s)
      Miho Sumiyoshi, Rin Kurahara, Ryuji Inoue
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of TRPC6 channel in fibrogenic stenosis in human intestinal myofibroblast2013

    • Author(s)
      Lin-Hai Kurahara, Miho Sumiyoshi, Ryuji Inoue
    • Organizer
      第86回日本薬理学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Involvement of TRPC6 channel in TGFβ1/SMAD/MAPK/PI3K signaling in human intestinal myofibroblast2013

    • Author(s)
      Miho Sumiyoshi, Lin-Hai Kurahara,Ryuji Inoue
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Involvement of TRPC channel in fibrogenic stenosis and inflammation in human colonic myofibroblast2013

    • Author(s)
      Lin-Hai Kurahara, Miho Sumiyoshi, Ryuji Inoue
    • Organizer
      第37回国際生理学会(IUPS)
    • Place of Presentation
      イギリス・バーミンガム
    • Related Report
      2012 Annual Research Report
  • [Presentation] 線維化促進因子 TGF-β1 下流に おける消化管筋線維芽細胞 TRPC4,C6 チャネ ルの役割2012

    • Author(s)
      Lin-Hai Kurahara, Miho Sumiyoshi, Ryuji Inoue
    • Organizer
      第63回西日本生理学会
    • Place of Presentation
      大分
    • Year and Date
      2012-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 炎症性腸疾患線維化狭窄にお ける消化管筋線維芽細胞 TRPC4,C6 チャネル の役割2012

    • Author(s)
      Lin-Hai Kurahara, Miho Sumiyoshi, Ryuji Inoue
    • Organizer
      第54回日本平滑筋学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-03
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト子宮内膜間質細胞の脱落膜化過程におけるTRPC1の役割2012

    • Author(s)
      瓦林靖広、倉原(海)琳、本田啓、市川純、井上隆司
    • Organizer
      第8回TRP研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2012-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Intestinal myofibroblast TRPC channels confer fibrogenetic potential for human stenosis2012

    • Author(s)
      Lin-Hai Kurahara, Ryuji Inoue
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Counteracting effect of TRPC1 mediated store-operated Ca2+ influx on TNFα-induced COX-2-dependent prostaglandin E2 production in human colonic myofibroblasts2012

    • Author(s)
      Lin-Hai Kurahara, Yasuhiro Kawarabayashi, Akira Honda, Ryuji Inoue
    • Organizer
      第10回日韓シンポジウム
    • Place of Presentation
      韓国慶州
    • Year and Date
      2012-02-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Counteracting effect of TRPC1 mediated store-operated Ca^<2+> influx on TNFα-induced COX-2-dependent prostaglandin E_2 production in human colonic myofibroblasts2012

    • Author(s)
      Lin-Hai Kurahara, Yasuhiro Kawarabayashi, Akira Honda, Ryuji Inoue
    • Organizer
      第10回日韓シンポジウム
    • Place of Presentation
      韓国慶州
    • Year and Date
      2012-02-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 炎症性腸疾患線維化狭窄における消化管筋線維芽細胞TRPC4,C6チャネルの役割2012

    • Author(s)
      倉原(海)琳、住吉美保、井上隆司
    • Organizer
      第54回日本平滑筋学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 線維化促進因子TGF-β1下流における消化管筋線維芽細胞TRPC4,C6チャネルの役割2012

    • Author(s)
      Lin-Hai Kurahara, Miho Sumiyoshi, Ryuji Inoue
    • Organizer
      第63回西日本生理学会
    • Place of Presentation
      大分
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト子宮内膜間質細胞の脱落膜化過程におけるTRPC1の役割2012

    • Author(s)
      瓦林靖広、倉原(海)琳、本田啓、市川純、井上隆司
    • Organizer
      第8回 TRP研究会
    • Place of Presentation
      岡崎
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腸管狭窄線維化の進行における消化管筋線維芽細胞 TRP チャネルの役割2011

    • Author(s)
      Hai Lin, Ryuji Inoue
    • Organizer
      第62回西日本生理学 会
    • Place of Presentation
      佐賀
    • Year and Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 腸管狭窄線維化の進行における消化管筋線維芽細胞TRPチャネルの役割2011

    • Author(s)
      Lin Kurahara, Ryuji Inoue
    • Organizer
      第62回西日本生理学会
    • Place of Presentation
      佐賀
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 消化管筋線維芽細胞におけるTRPC1/SOC/NF-κB シグナル伝達を介した COX-2 発現の制御2010

    • Author(s)
      Hai Lin, Yasuhiro Kawarabayashi, Akira Honda, Ryuji Inoue
    • Organizer
      第87回日本生理学会大会・シンポジウム
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム「ストア作動性カルシウム流入活性化機構とその生理的役割」消化管筋線維芽細胞におけるTRPC1/SOC/NF-κBシグナル伝達を介したCOX-2発現の制御2010

    • Author(s)
      倉原琳
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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