Novel therapeutic approaches of intestinal stenosis focused on myofibroblasts
Project/Area Number |
22790677
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
|
Research Institution | Fukuoka University |
Principal Investigator |
KURAHARA Lin (HAI Lin) 福岡大学, 医学部, 講師 (00341438)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 下部消化管学(小腸、大腸) / 組織線維化 / 炎症性腸疾患 / 線維化狭窄 / 筋線維芽細胞 / TRPC4 / TRPC6 / カルシウム / TGF-β1 / TGFβ1 / コラーゲン / TNFα / PGE2 / 腸管狭窄 / TRPC1 / Ca^<2+> / NF-κB / 線維化 |
Research Abstract |
TRPC4 and C6 channels may play non-trivial roles in myofibroblast transformation/differentiation, thereby promoting fibrogenesis in the colon. Our results also suggested that myfibroblast signaling pathways regulating interleukin production, which seem associated with the phosphorylation of Smad2, Erk1/2, and p38 MAPK as well as TRPC6-mediated Ca2+ influx. TRPC4 and TRPC6 could be a promising target in treating fibrotic and inflammatory bowel diseases.
|
Report
(4 results)
Research Products
(21 results)