Investigation the mechanisms of chronicity from acute hepatitis B using a next generation sequencer
| Project/Area Number |
22790679
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
ITO Kiyoaki 独立行政法人国立国際医療研究センター (50551420)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIYAMA Masasya (20612427)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | B型急性肝炎 / 慢性化 / SNPs / HBV / 次世代シーケンサー / GWAS / HLA-DP / ジェノタイプ |
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| Research Abstract |
We have investigated the both host and viral factors associated with chronicity from acute hepatitis B. Rs3077 and rs9277535 were genotyped by the invader method which we have developed. However, these SNPs were not associated with chronicity from acute hepatitis B in adults. We have analyzed the viral factor using a next generation sequencer, and could obtain the specific findings to analyze the number of clones.
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Report
(3 results)
Research Products
(16 results)
