Cardiac sympathetic nervous function in patients with atrial fibrillation

• Project/Area Number: 22790683
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Yamagata University
• Principal Investigator: ARIMOTO Takanori 山形大学, 医学部, 助教 (80400547)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 心房細動 / 心筋焼灼術 / 心臓交感神経 / 心臓MIBG / 心臟MIBG

Research Abstract

The ^<123>I-MIBG scintigraphy demonstrated an enhanced adrenergic nervous function (high washout rate) and decreased adrenergic nervous distribution (low heart to mediastinum ratios) in patients with both paroxysmal and persistent AF. Only the ^<123>I-MIBG washout rate was a multivariate predictor of an AF recurrence (hazard ratio : 1.6, 95% confidence interval : 1.004-1.125, P = 0.037).

Research Products

• [Journal Article] High washout rate of iodine-123-metaiodobenzyl-guanidine imaging predicts the outcome of catheter ablation of atrial fibrillation (2011)
  • Author(s): Arimoto T, Tada H, et al
  • Journal Title: J Cardiovasc Electrophysiol Volume: 22 Pages: 1297-1304
  • URL: http://dx.doi.10.1111/j.1540-8167.2011.02123.x.
  • Peer Reviewed
• [Journal Article] Difference of clinical course after catheter ablation of atrioventricular nodal reentrant tachycardia between younger and older patients : atrial vulnerability predicts new onset of atrial fibrillation (2011)
  • Author(s): Arimoto T, et al
  • Journal Title: Intern Med Volume: 50 Pages: 1649-1655
  • NAID: 130000969364
  • URL: http://dx.doi.org/10.2169/internalmedicine.50.5280
  • Peer Reviewed
• [Journal Article] High Washout Rate of Iodine-123-Metaiodobenzylguanidine Imaging Predicts the Outcome of Catheter Ablation of Atrial Fibrillation (2011)
  • Author(s): Takanori Arimoto
  • Journal Title: J Cardiovasc Electrophysiol Volume: 22 Issue: 12 Pages: 1297-1304
  • DOI: 10.1111/j.1540-8167.2011.02123.x
  • Peer Reviewed
• [Journal Article] Circulating heart-type fatty acid-binding protein levels predict the occurrence of appropriate shocks and cardiac death in patients with implantable cardioverter-defibrillator
  • Author(s): Daidoji H, Arimoto T, et al
  • Journal Title: J Card Fail Volume: (in press)
  • Peer Reviewed