Research of the elucidation of the mechanism in the development of calcific aortic valve stenosis by shear stress

• Project/Area Number: 22790685
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Yamagata University
• Principal Investigator: MIYAMOTO Takuya 山形大学, 医学部, 助教 (20447204)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 大動脈弁狭窄症 / 石灰化 / shear stress, osteoblast, Maf B / shear stress / osteoblast / Maf B / MafB

Research Abstract

We produced animal model of aortic stenosis (AS) by wire-injury of aortic valve of mice. Wire-injury induced significant AS and concentric cardiac hypertrophy and leaded to heart failure. We also documented the serial pathophysiological process including infiltration of inflammatory cell, phenotypic change of fibroblast to myofibroblast, and osteogenic differentiation in the injured valve tissue. This model might contribute to the understanding of pathogenesis of AS and new therapeutic strategy of AS.

Research Products

• [Journal Article] Prognostic Value of Low Left Atrial Appendage Wall Velocity in Patients with Ischemic Stroke and AtrialFibrillation (2012)
  • Author(s): Harutoshi Tamura
  • Journal Title: J Am Soc Echocardiogr Volume: 25 Issue: 5 Pages: 576-583
  • DOI: 10.1016/j.echo.2012.01.012
  • Peer Reviewed
• [Journal Article] Device troubleshooting : cross connection of ventricular leads in a patients with decreased right ventricular electrical activity (2012)
  • Author(s): Kutsuzawa D, Arimoto T, Miyamoto T, Kubota I, et al
  • Journal Title: Europace Volume: (Epub ahead of print) Issue: 8 Pages: 1217-1219
  • DOI: 10.1093/europace/eur420
  • Peer Reviewed
• [Journal Article] Serum pregnancy-associated plasma protein a in patients with heart failure (2011)
  • Author(s): Funayama A, Shishido T, Netsu S, Ishino M, Sasaki T, Katoh S, Takahashi H, Arimoto T, Miyamoto T, Nitobe J, Watanabe T, Kubota I
  • Journal Title: J Card Fail Volume: 17(10) Pages: 819-826
  • URL: http://dx.doi.org/10.1016/j.cardfail.2011.05.011
  • Peer Reviewed
• [Journal Article] Elevated cystatin C levels predict the incidence of vasospastic angina (2011)
  • Author(s): Funayama A, Watanabe T, Tamabuchi T, Otaki Y, Netsu S, Hasegawa H, Honda S, Ishino M, Arimoto T, Takahashi H, Shishido T, Miyamoto T, Nitobe J, Kubota I
  • Journal Title: Circ J Volume: 75(10) Pages: 2439-2444
  • NAID: 10029459648
  • URL: http://dx.doi.org/10.1253/circj.CJ-11-0008
  • Peer Reviewed
• [Journal Article] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event (2011)
  • Author(s): Susuki S, Shishido T, Ishino M, Katoh S, Sasaki T, Nishiyama S, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: Eur J Clin Invest Volume: 41(7) Pages: 759-766
  • URL: http://dx.doi.10.1111/j.1365-2362.2010.02465.x
  • Peer Reviewed
• [Journal Article] Increased left atrial volume index predicts a poor prognosis in patients with heart failure (2011)
  • Author(s): Tamura H, Watanabe T, Nishiyama S, Sasaki S, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Nitobe J, Nirono O, Kubota I
  • Journal Title: J Card Fail Volume: 17(3) Pages: 210-216
  • URL: http://dx.doi.org/10.1016/j.cardfail.2010.10.006
  • Peer Reviewed
• [Presentation] Deficiency of the long pentraxin PTX3 deteriorates neointimal hyperplasia after vascular injury (2011)
  • Author(s): Ishino M, Shishido T, Suzuki S, Katoh S, Sasaki T, Netsu S, Funayama A, Arimoto T, Nishiyama S, Takahashi H, Miyashita T, Miyamoto T, Watanabe T, Takeishi Y, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, America
• [Presentation] Midkine exacerbates cardiac hypertrophy and remodeling in response to pressure overload (2011)
  • Author(s): Netsu S, Shishido T, Ishino M, Kadowaki S, Narumi T, Otaki Y, Funayama A, Honda S, Hasegawa H, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, America
• [Presentation] Cardiac-specific overexpression of high mobility group box 1 (HMGB1) attenuates cardiac dysfunction induced by pressure overload (2011)
  • Author(s): Funayama A, Shishido T, Netsu S, Ishino M, Otaki Y, Honda S, Hasegawa H, Kadowaki S, Narumi T, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Woo CH, Kuwahara K, Nakao K, Takeishi Y, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, America
• [Book] 慢性心不全のトータルメネジメント.平成22年度山形県医師会学術雑誌 (2011)
  • Author(s): 宮本卓也
• [Book] 第III部治療における最近の新薬の位置付け〈薬効別〉～新薬の広場～心不全治療薬.医薬ジャーナル新薬展望2010 (2010)
  • Author(s): 宮本卓也