Role of chronic inflammation in cardiac lipotoxicity

• Project/Area Number: 22790691
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: EGUCHI Kosei 東京大学, 医学部・附属病院, 助教 (20529094)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 慢性炎症 / 飽和脂肪酸 / メタボリックシンドローム / パルミチン酸 / 炎症細胞

Research Abstract

We first developed a novel method to specifically increase the serum palmitate level in mice. In this model, strong induction of inflammation in the pancreatic islet, blood vessel smooth muscle cells and the heart was observed that was found to be one of the causes of the dysfunction in these organs. Our results suggest that free fatty acids are one of the factors that induce chronic inflammation and dysfunction in the cardiovascular and metabolic systems in obesity.

Research Products

• [Journal Article] Saturated fatty acid and TLR signaling linkβcell dysfunction and islet inflammation (2012)
  • Author(s): Kosei Eguchi, Ichiro Manabe, Yumiko Oishi-Tanaka, Mitsuru Ohsugi, Nozomu Kono, Fusa Ogata, Nobuhiro Yagi, Umeharu Ohto, Masao Kimoto, Kensuke Miyake, Kazuyuki Tobe, Hiroyuki Arai, Takashi Kadowaki, Ryozo Nagai
  • Journal Title: Cell Metabolism Volume: 15 Pages: 518-533
• [Journal Article] Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. (2012)
  • Author(s): Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R
  • Journal Title: Cell Metab. Volume: 15 Issue: 4 Pages: 518-533
  • DOI: 10.1016/j.cmet.2012.01.023
  • Peer Reviewed
• [Presentation] Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation (2012)
  • Author(s): Kosei Eguchi
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-03-16
• [Presentation] 2型糖尿病でのβ細胞機能障害における膵島炎症の役割 (2011)
  • Author(s): 江口航生、真鍋一郎、永井良三
  • Organizer: 第20回東京免疫フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2011-02-22
• [Presentation] Lipotoxicity involves inflammatory processes mediated by TLR4 signaling in vivo (2011)
  • Author(s): Eguchi K, Manabe I, Nagai R
  • Organizer: 第19回日本血管生物医学会
  • Place of Presentation: 東京
• [Presentation] Lipotoxicity involves inflammatory processes mediated by TLR4 signaling in vivo (2011)
  • Author(s): Eguchi K, Manabe I Nagai R
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, FL, USA
• [Presentation] 2型糖尿病でのβ細胞機能障害における膵島炎症の役割の解明 (2011)
  • Author(s): 江口航生、真鍋一郎、大杉満、門脇孝、永井良三
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路島
• [Presentation] 2型糖尿病のβ細胞機能障害における膵島炎症 (2011)
  • Author(s): 江口航生、真鍋一郎、大杉満、門脇孝、永井良三
  • Organizer: 第4回臨床研究フォーラム
  • Place of Presentation: 三島
• [Presentation] 遊離脂肪酸は膵島へのマクロファージの浸潤・炎症を誘導して膵β機能障害を惹起する (2011)
  • Author(s): 江口航生、真鍋一郎、永井良三
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌
• [Presentation] 飽和脂肪酸は膵島へのマクロファージの浸潤・炎症を誘導して膵β機能障害を惹起する (2011)
  • Author(s): 江口航生、真鍋一郎、大杉満、門脇孝、永井良三
  • Organizer: 第84回日本内分泌学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 三M1マクロファージの浸潤と膵島炎症が2型糖尿病におけるβ細胞機能障害に重要な役割を果たす (2010)
  • Author(s): 江口航生、真鍋一郎、大杉満、門脇孝、永井良
  • Organizer: 第22回分子糖尿病学研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-04
• [Presentation] Islet inflammation induced by free fatty acid-TLR4 pathway leads toβcell dysfunction in type 2 diabetes (2010)
  • Author(s): Eguchi K, Manabe I, Nagai R
  • Organizer: 第18回日本血管生物医学会
  • Place of Presentation: 大阪
• [Presentation] Free fatty acids induce dynamic inflammatory processes in pancreatic islets that lead toβcell dysfunction (2010)
  • Author(s): Eguchi K, Manabe I, Nagai R
  • Organizer: American Heart Association Scientific Sessions 2010
  • Place of Presentation: Chicago, IL, USA
• [Presentation] 遊離脂肪酸は膵島へのマクロファージ浸潤・炎症を誘導して膵β機能障害を惹起する (2010)
  • Author(s): 江口航生、真鍋一郎、沈華、永井良三
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋
• [Presentation] Free fatty acids induce dynamic inflammatory processes in pancreatic islets that lead toβcell dysfunction (2010)
  • Author(s): Eguchi K, Manabe I, Nagai R
  • Organizer: Cell symposium on Inflammation and disease
  • Place of Presentation: Lisbon, Portugal
• [Presentation] Palmitate induce dynamic inflammatory processes in pancreatic islets that lead toβcell dysfunction (2010)
  • Author(s): Eguchi K, Manabe I, Nagai R
  • Organizer: 14th Internatinal Congress on Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] 遊離脂肪酸は膵島へのマクロファージの浸潤・炎症を誘導して膵β機能障害を惹起する (2010)
  • Author(s): 江口航生、真鍋一郎、永井良三
  • Organizer: 第53会日本糖尿病学会
  • Place of Presentation: 岡山
• [Remarks]
  • URL: http://first.lifesciencedb.jp/archives/4730