Elucidation of a new mechanism of the cardiovascular pathologies by novel physiologically activity substance identified by proteomic analysis

• Project/Area Number: 22790692
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: AIZAWA Kenichi 東京大学, 医学部・附属病院, 特任助教 (70436484)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 循環器・高血圧 / ストレス / 蛋白質 / プロテオーム

Research Abstract

Cardiovascular diseases are main diseases to occupy the high rank of the cause of death in the developed nations including our country. The cardiovascular system maintains homeostasis through the control with the peptide-related bioactive substance and presents with the condition of a pathology onset at the time of the failure. In late years proteomics analysis particularlythe technological change of the mass spectrometer allowed high sensitivity measurement of a very small amount of protein. Diagnostic usefulness as the biomarkerwas shown by assuming a cardiovascular disease-specific bioactive substance a target in this study, and analyzing the condition of a patient in the coronary disease condition of a patient.

Research Products

• [Journal Article] Ataxia telangiectasia mutated(ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence (2010)
  • Author(s): Zhan H, Suzuki T, Aizawa K, Miyagawa K, Nagai R
  • Journal Title: Journal of Biological Chemistry Volume: 285 Pages: 29662-29670
  • Peer Reviewed
• [Journal Article] Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence. (2010)
  • Author(s): Zhan H, Suzuki T, Aizawa K, Miyagawa K, Nagai R
  • Journal Title: J Biol Chem Volume: 285 Pages: 29662-29670
  • Peer Reviewed
• [Presentation] Regulation of cardiac hypertrophy by DNA damage response as mediated by KLF5 (2012)
  • Author(s): Aizawa K, Suzuki T, Zhan H, Sawaki D, Ishida J, Nagai R
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-17
• [Presentation] Kruppel-like factor 6(KLF6) exacerbates glucose intolerance and obesity (2012)
  • Author(s): Ishida J, Suzuki T, Aizawa K, Sawaki D, Matsumura T, Friedman SL, Nagai R
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] Telangiectasia Mutated(ATM)-mediated DNA Damage Response Regulates Doxorubicin-induced Cardiotoxicity (2012)
  • Author(s): Zhan H, Suzuki T, Aizawa K, Sawaki D, Ishida J, Miyagawa K, Nagai R. Ataxia
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] Aortic remodeling stimulates aneurysm formation in apoE-/-mice through gp130/STAT3 signaling (2012)
  • Author(s): Son BK, Suzuki T, Sawaki D, Aizawa K, Matsumura T, Munemasa Y, Zhan H, Okamoto Y, Ishida J, Nagai R
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] KLF6 Modulates Recruitment and Polarization of Inflammatory Cells through Cardiomyocytes in Initiation of Cardiac Fibrosis (2012)
  • Author(s): Sawaki D, Suzuki T, Aizawa K, Matsumura T, Munemasa Y, Ishida J, Friedman SL^<2)>, Nagai R
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] Ataxia Telangiectasia Mutated (ATM)-mediated DNA Damage Response Regulates Doxorubicin-induced Cardiotoxicity (2012)
  • Author(s): Zhan H, Suzuki T, Aizawa K, Sawaki D, Ishida J, Miyagawa K, Nagai R
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cells senescence (2012)
  • Author(s): Zhan H, Suzuki T, Aizawa K, Miyagawa K, Nagai R
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] DNA damage response is important in the regulation of cardiac hypertrophy (2011)
  • Author(s): Aizawa K, Suzuki T, Zhan H, Sawaki D, Ishida J, Mastumura T, Nagai R
  • Organizer: American Heart Association, Scientific Session 2011
  • Place of Presentation: オーランド(米国)
  • Year and Date: 2011-11-16
• [Presentation] Kruppel-like Factor 6 modulates initiation of cardiac fibrosis. 2010 FASEB Summer Research Conferences (2011)
  • Author(s): Sawaki D, Suzuki T, Aizawa K, Matsumura T, Munemasa Y, Ishida J, Friedman SL, Nagai R
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-03
• [Presentation] Ataxia telangiectasia mutated(ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cells senescence (2011)
  • Author(s): Zhan H, Suzuki T, Aizawa K, Miyagawa K, Nagai R
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Kruppel-like Factor 6(KLF6) is Involved in Glucose Intolerance and Obesity (2011)
  • Author(s): Ishida J, Suzuki T, Aizawa K, Sawaki D, Matsumura T, Friedman SL, Nagai R
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Ataxiatelangiectasia mutated(ATM)-mediated DNA damage response in oxidativestress-induced vascular endothelial cells senescence (2011)
  • Author(s): Aizawa K, Suzuki T, Zhan H, Miyagawa K, Nagai R
  • Organizer: 2011 Gordon Research Conferences ; Mammalian DNA Repair
  • Place of Presentation: Ventura, CA, USA
• [Presentation] Ataxiatelangiectasia mutated (ATM)-mediated DNA damage response in oxidativestress-induced vascular endothelial cells senescence (2011)
  • Author(s): Aizawa K, Suzuki T, Zhan H, Miyagawa K, Nagai R
  • Organizer: 2011 Gordon Research Conferences ; Mammalian DNA Repair
  • Place of Presentation: Ventura, CA, USA
• [Presentation] Kruppel-like Factor 6 modulates initiation of cardiac fibrosis (2010)
  • Author(s): Sawaki D, Suzuki T, Aizawa K, Matsumura T, Munemasa Y, Ishida J, Friedman SL, Nagai R
  • Organizer: 2010 FASEB Summer Research Conferences
  • Place of Presentation: Steamboat Springs, CO, USA
  • Year and Date: 2010-08-12
• [Presentation] Kruppel-like factor 6(KLF6) is involved in adiposity (2010)
  • Author(s): Ishida J, Suzuki T, Aizawa K, Sawaki D, Matsumura T, Friedman SL, Nagai R
  • Organizer: 2010 FASEB Summer Research Conferences
  • Place of Presentation: Steamboat Springs, CO, USA
  • Year and Date: 2010-08-11
• [Presentation] 心血管病態におけるプロテオミクス解析法を用いた新規シグナル伝達経路の同定 (2010)
  • Author(s): 相澤健一、鈴木亨、永井良三
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京
• [Presentation] Identification of a new regulatory pathway of pathologic vascular injury as mediated by KLF5 by proteome analysis (2010)
  • Author(s): Aizawa K, Suzuki T, Matsumura T, Sawaki D, Ishida J, Nagai
  • Organizer: 2010 FASEB Summer Research Conferences
  • Place of Presentation: Steamboat Springs, CO, USA
• [Presentation] Ataxia telangiectasia mutated mediates oxidative stress-induced premature cell senescence in vacular endothelial cells (2010)
  • Author(s): Aizawa K, Suzuki T, Zhan H, Matsumura T, Sawaki D, Ishida J, Miyagawa K, Nagai R
  • Organizer: 16th International vascular Biology Meeting
  • Place of Presentation: Los Angeles, CA, USA
• [Presentation] Ataxia telangiectasia mutated mediates oxidative stress-induced premature cell senescence in vacular endothelial cells. 16th International vascular Biology Meeting (2010)
  • Author(s): Aizawa K, Suzuki T, Zhan H, Matsumura T, Sawaki D, Ishida J, Miyagawa K, Nagai R
  • Organizer: 16th International vascular Biology Meeting
  • Place of Presentation: Los Angeles, CA, USA
• [Remarks] ユビキタス予防医学講座ホームページ
  • URL: http://plaza.umin.ac.jp/upm/
• [Remarks]
  • URL: http://plaza.umin.ac.jp/upm/
• [Remarks]
  • URL: http://plaza.umin.ac.jp/upm/