Association between genetic and clinical characteristics and tailor made therapy in idiopathic ventricular fibrillation

• Project/Area Number: 22790696
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Niigata University
• Principal Investigator: WATANABE Hiroshi 新潟大学, 医歯学総合病院, 助教 (10547558)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 不整脈 / 心電図 / 遺伝子 / イオンチャネル / リスクファクター

Research Abstract

There has been increasing interest in idiopathic ventricular fibrillation, but the clinical characteristics, underlying mechanisms, and genetic background are unclear. Furthermore, the data for risk stratification to prevent sudden death is not enough. We identified clinical characteristics, novel genetic background, and the underlying mechanisms in idiopathic ventricular fibrillation. We also found risk factors for arrhythmia recurrences that are useful for tailor made therapy.

Research Products

• [Journal Article] The cholesterol paradox in atrial fibrillation (2012)
  • Author(s): Watanabe H, Yagihara N, Aizawa Y, Kodama M, Tanabe N, Watanabe T
  • Journal Title: Circ J
• [Journal Article] Response to letter regarding article,"electrocardiographic characteristics and scn5a mutations in idiopathic ventricular fibrillation associated with early repolarization" (2012)
  • Author(s): Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M,Aizawa Y, Shimizu W, Makita N
  • Journal Title: Circ Arrhythm Electrophysiol Pages: 60-61
• [Journal Article] Electrocardiographic abnormalities and risk of complete atrioventricular block (2012)
  • Author(s): Watanabe H, Makita N, Tanabe N, Watanabe T, Aizawa Y
  • Journal Title: Int J Cardiol Volume: 155 Pages: 462-464
• [Journal Article] Age and sex differences in association of blood lipid levels with incidence of atrial fibrillation (2012)
  • Author(s): Watanabe H, Aizawa Y
  • Journal Title: Circ Arrhythm Electrophysiol Volume: (In press)
• [Journal Article] A connexin40 mutation associated with a malignant variant of progressive familial heart block type i (2012)
  • Author(s): Makita N, Seki A, Sumitomo N, Chkourko H, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR, Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AA, Probst V, Le Marec H, Roden DM, Mochizuki N, Schott JJ, Delmar M
  • Journal Title: Circ Arrhythm Electrophysiol Volume: 5 Pages: 163-172
  • NAID: 120006985450
• [Journal Article] Early repolarization and its modification by preexcitation in two patients with intermittent WPW syndrome (2012)
  • Author(s): Hasegawa K, Sato A, Watanabe H, Furushima H, Chinushi M, Aizawa Y
  • Journal Title: Pacing Clin Electrophysiol
• [Journal Article] Is the coexistence of sustained st-segment elevation and abnormal q waves a risk factor for electrical storm in implanted cardioverter defibrillator patients with structural heart diseases? (2012)
  • Author(s): Furushima H, Chinushi M, Iijima K, Hasegawa K, Sato A, Izumi D, Watanabe H, Aizawa Y
  • Journal Title: Europace Volume: 14 Pages: 675-681
• [Journal Article] Exercise-related qt interval shortening with a peaked t wave in a healthy boy with a family history of sudden cardiac death (2012)
  • Author(s): Chinushi M, Sato A, Iijima K, Suzuki K, Hiroshi F, Izumi D, Watanabe H, Kanae H, Aizawa Y
  • Journal Title: Pacing Clin Electrophysiol
• [Journal Article] Electrocardiographic abnormalities and risk of complete atrioventricular block (2012)
  • Author(s): Watanabe H, Makita N, et al
  • Journal Title: Int J Cardiol Volume: 155 Issue: 3 Pages: 462-464
  • DOI: 10.1016/j.ijcard.2011.12.028
  • Peer Reviewed
• [Journal Article] The prevalence of early repolarization in wolff-parkinson-white syndrome with a special reference to j waves and the effects of catheter ablation (2011)
  • Author(s): Yagihara N, Sato A, Iijima K, Izumi D, Furushima H, Watanabe H, Irie T, Kaneko Y, Kurabayashi M, Chinushi M, Satou M, Aizawa Y
  • Journal Title: J Electrocardiol
• [Journal Article] Striking in vivo phenotype of a disease-associated human scn5a mutation producing minimal changes in vitro (2011)
  • Author(s): Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL, Jr., Roden DM
  • Journal Title: Circulation Volume: 124 Pages: 1001-1011
• [Journal Article] Association between lipid profile and risk of atrial fibrillation (2011)
  • Author(s): Watanabe H, Tanabe N, Yagihara N, Watanabe T, Aizawa Y, Kodama M
  • Journal Title: Circ J Volume: 75 Pages: 2767-2774
• [Journal Article] Mechanism of antiarrhythmic effects of flecainide in catecholaminergic polymorphic ventricular tachycardia (2011)
  • Author(s): Watanabe H, Steele DS, Knollmann BC
  • Journal Title: Circ Res Volume: 109 Pages: 712-713
• [Journal Article] Electrocardiographic characteristics and scn5a mutations in idiopathic ventricular fibrillation associated with early repolarization (2011)
  • Author(s): Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N
  • Journal Title: Circ Arrhythm Electrophysiol Volume: 4 Pages: 874-881
• [Journal Article] Mechanism underlying catecholaminergic polymorphic ventricular tachycardia and approaches to therapy (2011)
  • Author(s): Watanabe H, Knollmann BC
  • Journal Title: J Electrocardiol Volume: 44 Pages: 650-655
• [Journal Article] Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (2011)
  • Author(s): van der Werf C, Kannankeril PJ, Sacher F, Krahn AD, Viskin S, Leenhardt A, Shimizu W, Sumitomo N, Fish FA, Bhuiyan ZA, Willems AR, van der Veen MJ, Watanabe H, Laborderie J, Haissaguerre M, Knollmann BC, Wilde AA
  • Journal Title: J Am Coll Cardiol Volume: 57 Pages: 2244-2254
• [Journal Article] Analysis of j waves during myocardial ischaemia (2011)
  • Author(s): Sato A, Tanabe Y, Chinushi M, Hayashi Y, Yoshida T, Ito E, Izumi D, Iijima K, Yagihara N, Watanabe H, Furushima H, Aizawa Y
  • Journal Title: Europace
• [Journal Article] An appropriate defibrillation threshold obtained by the combined connection between two shock leads and icd generator (2011)
  • Author(s): Sato A, Chinushi M, Iijima K, Watanabe H, Izumi D, Furushima H, Sonoda K, Hasegawa K, Yagihara N, Aizawa Y
  • Journal Title: Intern Med Volume: 50 Pages: 2815-2818
  • NAID: 130002130066
• [Journal Article] Rise in international normalized ratio after a catastrophic earthquake in patients treated with warfarin (2011)
  • Author(s): Oda M, Watanabe H, Oda E, Tomita M, Obata H, Ozawa T, Oda Y, Iizuka T, Toba K, Aizawa Y
  • Journal Title: Int J Cardiol
• [Journal Article] Preexcitation unmasks j waves : 2 cases (2011)
  • Author(s): Nagao S, Hayashi Y, Yagihara N, Sato A, Watanabe H, Furushima H, Chinushi M, Aizawa Y
  • Journal Title: J Electrocardiol Volume: 44 Pages: 359-362
• [Journal Article] Is the coexistence of sustained st-segment elevation and abnormal q waves a risk factor for electrical storm in implanted cardioverter defibrillator patients with structural heart diseases? (2011)
  • Author(s): Furushima H, Chinushi M, Iijima K, Hasegawa K, Sato A, Izumi D, Watanabe H, Aizawa Y
  • Journal Title: Europace
• [Journal Article] Suppression of storms of ventricular tachycardia by epicardial ablation of isolated delayed potential in noncompaction cardiomyopathy (2011)
  • Author(s): Chinushi M, Iijima K, Furushima H, Izumi D, Sato A, Yagihara N, Hasegawa K, Watanabe H, Soejima K, Aizawa Y
  • Journal Title: Pacing Clin Electrophysiol
• [Journal Article] Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel (2011)
  • Author(s): Atack TC, Myers Stroud D, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM
  • Journal Title: Circ Res Volume: 109 Pages: 38-46
• [Journal Article] Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated with Early Repolarization (2011)
  • Author(s): Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N
  • Journal Title: Circ Arrhythm Electrophysiol Volume: 4 Issue: 6 Pages: 874-881
  • DOI: 10.1161/circep.111.963983
  • Peer Reviewed
• [Journal Article] Mechanism of antiarrhythmic effects of flecainide in catecholaminergic polymorphic ventricular tachycardia (2011)
  • Author(s): 渡部裕
  • Journal Title: Circulation Research Volume: 109 Issue: 6 Pages: 712-713
  • DOI: 10.1161/circresaha.111.251322
  • Peer Reviewed
• [Journal Article] High prevalence of early repolarization in short QT syndrome (2010)
  • Author(s): 渡部裕
  • Journal Title: Heart Rhythm Volume: 4 Pages: 647-652
  • Peer Reviewed
• [Journal Article] ガイドラインに基づく不整脈症例の診療 (2010)
  • Author(s): 渡部裕
  • Journal Title: 総合臨床 Volume: 2010年増刊 Pages: 726-729
• [Presentation] Clinical, Electrocardiographic, and Genetic Characteristics of Patients with Idiopathic Ventricular Fibrillation associated with Early Repolarization (2011)
  • Author(s): 渡部裕
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: アメリカ・オーランド
  • Year and Date: 2011-11-13
• [Presentation] Short QT syndromeとJ波・早期再分極 (2011)
  • Author(s): 渡部裕
  • Organizer: 第46回理論心電図研究会
  • Place of Presentation: 博多(招待講演)
  • Year and Date: 2011-09-20
• [Presentation] Short QT syndromeにおける早期再分極 (2011)
  • Author(s): 渡部裕
  • Organizer: 第26回犬山不整脈カンファランス
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-08-20
• [Presentation] Effects of Flecainide in Genotype-negative Catecholaminergic Polymorphic Ventricular Tachycardia (2011)
  • Author(s): 渡部裕
  • Organizer: Annual Meeting of Heart Rhythm Society
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2011-05-05
• [Presentation] Mechanism underlying Catecholaminergic Polymorphic Ventricular Tachycardia and approaches to therapy (2011)
  • Author(s): 渡部裕
  • Organizer: Annual Meeting of International Society for Computerized Electrocardiology
  • Place of Presentation: サンノゼ(招待講演)
  • Year and Date: 2011-04-14
• [Presentation] Ventricular arrhythmia ; Acute and long term response to drugs (2010)
  • Author(s): 渡部裕
  • Organizer: XIV International Symposium on Progress in Clinical Pacing
  • Place of Presentation: イタリア・ローマ(招待講演)
  • Year and Date: 2010-12-02
• [Presentation] Not so innocent : "bystander" accessory subunits and arrhythmogenesis (2010)
  • Author(s): 渡部裕
  • Organizer: ヨーロッパ心臓病学会総会
  • Place of Presentation: スペイン・バルセロナ(招待講演)
  • Year and Date: 2010-08-31
• [Presentation] Clinical, Electrocardiographic, and Genetic Characteristics of Patients with Idiopathic Ventricular Fibrillation associated with Early Repolarization
  • Author(s): 渡部裕
  • Organizer: AHA Scientific Sessions 2011
• [Presentation] Effects of Flecainide in Genotype-negative Catecholaminergic Polymorphic Ventricular Tachycardia
  • Author(s): 渡部裕
  • Organizer: Heart Rhythm 2011
• [Presentation] Electrocardiographic risk factors for complete atrioventric ular block
  • Author(s): Watanabe H, Watanabe T, Tanabe N, Ai zawa Y, Makita N
  • Organizer: The Niigata Preventive Med icine Study. AHA Scientific Sessions 2010