Elucidation of mechanism of cardioprotective effect by wnt11 and development of therapeutic application
| Project/Area Number |
22790698
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | wnt11 / アデノ関連ウイルス-9(AAV9) / 心筋炎 / 炎症抑制 / アデノ関連ウイルス9 / ウイルス性心筋炎 / Raw細胞 / アデノ関連ウイルス(AAV) / AAV9-wnt11 / wnt11産生HEK293細胞 |
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| Research Abstract |
Wnt11 therapy using adeno-associated virus improved survival of mice with myocarditis by about 30%. We tried to clarify the mechanism to improve survival. We found wnt11 significantly suppressed the production of inflammatory cytokines from activated Raw cells which are cell line of macrophage. We showed wnt11 has therapeutic effect on virus-induced myocarditis.
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Report
(3 results)
Research Products
(2 results)
