Elucidation of mechanism of cardioprotective effect by wnt11 and development of therapeutic application

Research Project

Project/Area Number	22790698
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Circulatory organs internal medicine
Research Institution	Nagoya University
Principal Investigator	KOBAYASHI Koichi 名古屋大学, 医学部附属病院, 助教 (20567010)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	wnt11 / アデノ関連ウイルス-9(AAV9) / 心筋炎 / 炎症抑制 / アデノ関連ウイルス9 / ウイルス性心筋炎 / Raw細胞 / アデノ関連ウイルス(AAV) / AAV9-wnt11 / wnt11産生HEK293細胞
Research Abstract	Wnt11 therapy using adeno-associated virus improved survival of mice with myocarditis by about 30%. We tried to clarify the mechanism to improve survival. We found wnt11 significantly suppressed the production of inflammatory cytokines from activated Raw cells which are cell line of macrophage. We showed wnt11 has therapeutic effect on virus-induced myocarditis.

Report

(3 results)