Relationship between renal function and composition of coronary arterial atherosclerotic plaques

• Project/Area Number: 22790699
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Nagoya University
• Principal Investigator: ISHII Hideki 名古屋大学, 大学院・医学系研究科, 助教 (90456674)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 循環器 / 冠動脈 / 腎障害 / 血管内超音波 / 冠動脈形成術 / 動脈硬化 / 慢性腎疾患 / 心筋障害

Research Abstract

The present study was conducted to identify any relationship between estimated glomerular filtration rate(eGFR) and coronary plaque characteristics using integrated backscatter intravascular ultrasound(IB-IVUS) which can detect coronary plaque composition. eGFR significantly correlated with both parameters(r=-0. 68, p<0. 001 and r=0. 69, p<0. 001, respectively). In conclusion, lower eGFR levels are associated with higher lipid and lower fibrous contents, contributing to coronary plaque vulnerability.

Research Products

• [Journal Article] Relation between estimated glomerular filtration rate and composition of coronary arterial atherosclerotic plaques. (2012)
  • Author(s): Hayano S, Matsubara T
  • Journal Title: American Journal of Cardiology Volume: 109巻 Issue: 8 Pages: 1131-1136
  • DOI: 10.1016/j.amjcard.2011.11.052
  • Peer Reviewed
• [Journal Article] Impact of chronic kidney disease on the incidence of peri-procedural myocardial injury in patients undergoing elective stent implantation. (2012)
  • Author(s): Kumagai S, Matsubara T
  • Journal Title: Nephrology Dialysis Transplantation Volume: 27巻 Issue: 3 Pages: 1059-1063
  • DOI: 10.1093/ndt/gfr411
  • Peer Reviewed
• [Journal Article] Association of cardiorespiratory fitness with characteristics of coronary plaque : assessment using integrated backscatter intravascular ultrasound and optical coherence tomography (2012)
  • Author(s): Yoshikawa D, Ishii H, Kurebayashi N, Okada T, Sato B, Ando H, Hayakawa S, Hayashi M, Isobe s, Hirashiki A, Okumura N, Takeshita K, Amano T, Uetani T, Yamada S, Murohara T
  • Journal Title: International Journal of Cardiology Volume: (In press) Issue: 2 Pages: 123-128
  • DOI: 10.1016/j.ijcard.2011.05.047
  • Peer Reviewed
• [Journal Article] Impact of diabetes and glycaemic control on peripheral artery disease in Japanese patients with endstage renal disease: long-term follow-up study from the beginning of haemodialysis. (2012)
  • Author(s): Ishii H, Matsubara T
  • Journal Title: Diabetologia Volume: 55巻 Issue: 5 Pages: 1304-1309
  • DOI: 10.1007/s00125-012-2473-9
  • Peer Reviewed
• [Journal Article] Impact of the low-to high-density lipoprotein cholesterol ratio oncomposition of angiographically ambiguous left main coronary artery plaque (2011)
  • Author(s): Kurebayashi N, Yoshikawa D, Ishii H, Sato B, Ando H, Okada T, Hayakawa S, Okumura N, Isobe S, Takeshita K, Hayashi M, Uetani T, Amano T, Murohara T.
  • Journal Title: Circ J Volume: 75 Pages: 1960-1967
  • Peer Reviewed
• [Journal Article] Impact of the Low- to High-Density Lipoprotein Cholesterol Ratio on Composition of Angiographically Ambiguous Left Main Coronary Artery Plaque (2011)
  • Author(s): Kurebayashi N, Yoshikawa D, Ishii H, Sato B, Ando H, Okada T, Hayakawa S, Okumura N, Isobe S, Takeshita K, Hayashi M, Uetani T, Amano T, Murohara T
  • Journal Title: Circulation Journal Volume: 75 Issue: 8 Pages: 1960-1967
  • DOI: 10.1253/circj.CJ-11-0019
  • NAID: 10029128155
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Relationship between estimated glomerular filtration rate and composition of coronary arterial atherosclerotic plaques
  • Author(s): Hayano S, Ichimiya S, Ishii H, Kanashiro M, Watanabe J, MD, Kurebayashi N, Yoshikawa D, Amano T, Matsubara T, Murohara T. Amano T, Matsubara T, Murohara T.
  • Journal Title: Am J Cardiol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Impact of chronic kidney disease on the incidence of peri-procedural myocardial injury in patients undergoing elective stent implantation
  • Author(s): Kumagai S, Ishii H, Amano T, Uetani T, Kato B, Harada K, Yoshida K, Ando H, Kunimura A, Shimbo Y, Kitagawa K, Harada K, Hayashi M, Yoshikawa D, Matsubara T, Murohara T.
  • Journal Title: Nephrol Dialysis Transplantation Volume: (in press)
  • Peer Reviewed
• [Journal Article] characteristics of coronary plaque : assessment using integrated backscatter intravascular ultrasound and optical coherence tomography
  • Author(s): Yoshikawa D, Ishii H, Kurebayashi N, Okada T, Sato B, Ando H, Hayakawa S, Hayashi M, Isobe S, Hirashiki A, Okumura N, Takeshita K, Amano T, Uetani T, Yamada S, Murohara T.
  • Journal Title: Int J Cardiol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Impact of diabetes and glycaemic control on peripheral artery disease in Japanese patients with end-stage renal disease. Long-term follow-up study from beginning of haemodialysis
  • Author(s): Ishii H, Kumada Y, Takahashi H, Toriyama T, Aoyama T, Tanaka M, Yoshikawa D, Hayashi M, Kasuga H, Yasuda Y, Maruyama S, Matsubara T, Matsuo S, Murohara T.
  • Journal Title: Diabetologia Volume: (in press)
  • Peer Reviewed
• [Presentation] Tissue Characterization of Coronary Plaque in Patients With Renal Dysfunction (2011)
  • Author(s): Hayano S, Ishii H, Ichimiya S, Kanashiro M, Watanabe J, Yoshikawa D, Matsubara T, Murohara T.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2011-11-16
• [Presentation] Tissue Characterization of Coronary Plaque in Patients With Renal Dysfunction (2011)
  • Author(s): Hayano S, Ishii H, Ichimiya S, Kanashiro M, Watanabe J, Yoshikawa D, Matsubara T, Murohara T
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2011-11-16
• [Presentation] Impact of Low-Density to High-Density Lipoprotein Cholesterol Ratio on Composition of Angiographically Ambiguous Left Main Coronary Artery Plaque (2011)
  • Author(s): Kurebayashi S, Yoshikawa D, Ishii H, Sato B, Ando H, Okada T, Hayakawa S, Murakami R, Isobe S, Takeshita K, Hayashi M, Amano T, Uetani T, Murohara T
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-03-20
• [Presentation] Impact of High-Density Lipoprotein Cholesterol Levels on Peri-Procedural Myocardial Injury Post Elective Stent Implantation in Patients with Chronic Statin Treatment (2011)
  • Author(s): Okada T, Yoshikawa D, Ishii H, Sato B, Kurebayashi N, Ando H, Hayakawa S, Hayashi M, Murohara T
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-03-19
• [Presentation] Impact of Chronic Kidney Disease on the Incidence of Post-Procedural Myocardial Infarction in Patients Undergoing Elective Stent Implantation (2011)
  • Author(s): Kumagai S, Amano T, Matsubara T, Uetani T, Nanki M, Marui N, Katoh M, Katoh B, Yoshida T, Harada K, Kunimura A, Shinbo Y, Kitagawa K, Ishii H, Murohara T
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-03-18