Elucidation of the function of microRNAs on cardiovascular and metabolic disease : Investigation for a novel therapy by regulating microRNAs
Project/Area Number |
22790703
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Kyoto University |
Principal Investigator |
HORIE Takahiro 京都大学, 医学研究科, 特定助教 (20565577)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | マイクロRNA / 動脈硬化 / コレステロール / HDL / 心不全 / ドキソルビシン |
Research Abstract |
Small non-coding RNAs termed microRNAs, about 20bp, bind to the 3' UTR of target mRNAs and inhibit their expressions post-transcriptionally. Recently, dysregulation of microRNA expression or function has been found to be relevant to various diseases in human. In this study, we investigated the function of microRNAs on cardiovascular and metabolic diseases, and found that microRNA-33 regulated HDL cholesterol metabolism and microRNA-146a was associated with doxorubicin-induced cardiac damage.
|
Report
(3 results)
Research Products
(55 results)
-
[Journal Article] Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage2011
Author(s)
Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Kinoshita M, Watanabe S, Baba O, Kojima Y, Shizuta S, Imai M, Tamura T, Kita T, Kimura T
-
Journal Title
Circ Cardiovasc Genet
Volume: 4
Issue: 4
Pages: 446-454
DOI
Related Report
Peer Reviewed
-
[Journal Article] Distinct characteristics of circulating vascular endothelial growth factor-A and C levels in human subjects2011
Author(s)
Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa K.
-
Journal Title
Pros ONE
Volume: 6
Issue: 12
Pages: 29351-29351
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Micro RNA-33 encoded by an intron of Srebp2 regulates HDL in vivo2010
Author(s)
Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T
-
Journal Title
Proc Natl Acad Sci USA
Volume: 107
Pages: 17321-6
Related Report
Peer Reviewed
-
-
[Journal Article] Acute Doxorubicin Cardiotoxicity Is Associated with miR-146a-induced Inhibition of the Neuregulin-ErbB Pathway2010
Author(s)
Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T.
-
Journal Title
Cardiovascular Res
Volume: 87
Pages: 656-664
Related Report
Peer Reviewed
-
[Journal Article] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via ARL2 in neonatal rat cardiac myocytes2010
Author(s)
Nishi H, Ono K, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe Mori R, Hasegawa K, Kita T, Kimura T.
-
Journal Title
J Biol Chem
Volume: 285
Pages: 4920-30
Related Report
Peer Reviewed
-
[Journal Article] Neural cell adhesion molecule is a cardio protective factor up-regulated by metabolic stress2010
Author(s)
Nagao K, Ono K, Iwanaga Y, Tamaki Y, Kojima Y, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Hasegawa K, Kita T, Kimura T.
-
Journal Title
Journal of Molecular and Cellular Cardiology
Volume: 48
Pages: 1157-68
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] MicroRNA-33 encoded by an intron of Srebp2 regulates HDL in vivo2010
Author(s)
Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T.
-
Journal Title
Proc Natl Acad Sci U S A.
Volume: 107
Pages: 17321-6
Related Report
Peer Reviewed
-
-
[Journal Article] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via ARL2 in neonatal rat cardiac myocytes.2010
Author(s)
Nishi H, Ono K, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe Mori R, Hasegawa K, Kita T, Kimura T.
-
Journal Title
J Biol Chem.
Volume: 285
Pages: 4920-30
Related Report
Peer Reviewed
-
[Journal Article] Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress.2010
Author(s)
Nagao K, Ono K, Iwanaga Y, Tamaki Y, Kojima Y, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Hasegawa K, Kita T, Kimura T
-
Journal Title
Journal of Molecular and Cellular Cardiology.
Volume: 48
Pages: 1157-68
NAID
Related Report
Peer Reviewed
-
-
[Presentation] MicroRNA-33 Regulates Atherosclerosis Formation2012
Author(s)
Takahiro Horie, Osamu Baba, Koh Ono, Shin Watanabe, Hitoo Nishi, Minako Kinoshita, Yasuhide Kuwabara, Yoshimasa Chujo, Naoya Sowa, Koji Hasegawa, Noriaki Kum, Masayuki Yokode, Toru Kita, Takeshi Kimura
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡国際会議場(福岡)
Related Report
-
-
-
-
[Presentation] MicroRNA-33 Regulates Atherosclerosis Formation2012
Author(s)
Takahiro Horie, Osamu Baba, Koh Ono, Shin Watanabe, Hitoo Nishi, Minako Kinoshita, Yasuhide Kuwabara, Yoshimasa Chujo, Naoya Sowa, Koji Hasegawa, Noriaki Kume, Masayuki Yokode, Toru Kita, Takeshi Kimura
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡
Related Report
-
-
-
-
[Presentation] Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients with Cardiovascular Disease Indicate the Existence of Myocardial Damage2011
Author(s)
Yasuhide Kuwabara, Koh Ono, Takahiro Horie, Hitoo Nishi, Shin Watanabe, Minako Kinoshita, Osamu Baba, Yoshimasa Chujo, Kazuya Nagao, Yoji Kojima, Toru Kita, Takeshi Kimura
Organizer
American Heart Association Scientific Sessions 2011
Place of Presentation
Orange County Convention Center(Orlando, USA)
Related Report
-
-
-
-
[Presentation] Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients with Cardiovascular Disease Indicate the Existence of Myocardial Damage2011
Author(s)
Yasuhide Kuwabara, Koh Ono, Takahiro Horie, Hitoo Nishi, Shin Watanabe, Minako Kinoshita, Osamu Baba, Yoshimsa Chuio, Kazuya Nagao, Yoii Kojima, Toru Kita, Takeshi Kimura
Organizer
American Heart Association Scientific Sessions 2011
Place of Presentation
Orlando (America)
Related Report
-
-
-
-
-
-
[Presentation] MiR-146a-induced inhibition of the neuregulin-ErbB4 pathway may be involved in deterioration of cardiotoxicity under concurrent chemotherapy with doxorubicin and Trastuzumab2010
Author(s)
Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T
Organizer
American Heart Association Annual Scientific Sessions 2010
Place of Presentation
McCormick Place(Chicago, USA)
Related Report
-
-
-
[Presentation] MicroRNA-27a regulates beta-myocin heavy chain gene expression by targeting thyroid hormone receptor beta 1 in neonatal rat ventricular myocytes2010
Author(s)
Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Baba O, Nakashima Y, Nagao K, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T.
Organizer
American Heart Association Annual Scientific Sessions 2010
Place of Presentation
McCormick Place(Chicago, USA)
Related Report
-
[Presentation] MicroRNA-1 and microRNA-133a are useful as early diagnostic biomarkers in patients with acute coronary syndrome2010
Author(s)
Kuwabara Y, Ono K, Horie T, Nishi H, Kinoshita M, Watanabe S, Nakashima Y, Nagao K, Kojima Y, Kita T, Kimura T.
Organizer
American Heart Association Annual Scientific Sessions 2010
Place of Presentation
McCormick Place(Chicago, USA)
Related Report
-
-
-
-
[Presentation] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes2010
Author(s)
Ono K, Nishi H, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T.
Organizer
ISHR World Congress 2010 Kyoto
Place of Presentation
京都国際会議場(京都)
Related Report
-
[Presentation] MiR-146a-induced inhibition of the neuregulin-ErbB4 pathway may be involved in deterioration of cardiotoxicity under concurrent chemotherapy with doxorubicin and Trastuzumab.2010
Author(s)
Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T
Organizer
American Heart Association Annual Scientific Sessions 2010
Place of Presentation
Chicago, Illinois, USA
Related Report
-
-
-
[Presentation] MicroRNA-27a regulates beta-myocin heavy chain gene expression by targeting thyroid hormone receptor beta 1 in neonatal rat ventricular my ocytes.2010
Author(s)
Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Baba O, Nakashima Y, Nagao K, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
Organizer
American Heart Association Annual Scientific Sessions 2010
Place of Presentation
Chicago, Illinois, USA
Related Report
-
[Presentation] MicroRNA-1 and microRNA-133a are useful as early diagnostic biomarkers in patients with acute coronary syndrome.2010
Author(s)
Kuwabara Y, Ono K, Horie T, Nishi H, Kinoshita M, Watanabe S, Nakashima Y, Nagao K, Kojima Y, Kita T, Kimura T
Organizer
American Heart Association Annual Scientific Sessions 2010
Place of Presentation
Chicago, Illinois, USA
Related Report
-
-
-
[Presentation] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Ar12 in neonatal rat cardiac myocytes.2010
Author(s)
Ono K, Nishi H, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
Organizer
ISHR World Congress 2010 Kyoto
Place of Presentation
京都
Related Report
-
-
-
-