| Project/Area Number |
22790703
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
HORIE Takahiro 京都大学, 医学研究科, 特定助教 (20565577)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
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| Keywords | マイクロRNA / 動脈硬化 / コレステロール / HDL / 心不全 / ドキソルビシン |
|---|
| Research Abstract |
Small non-coding RNAs termed microRNAs, about 20bp, bind to the 3' UTR of target mRNAs and inhibit their expressions post-transcriptionally. Recently, dysregulation of microRNA expression or function has been found to be relevant to various diseases in human. In this study, we investigated the function of microRNAs on cardiovascular and metabolic diseases, and found that microRNA-33 regulated HDL cholesterol metabolism and microRNA-146a was associated with doxorubicin-induced cardiac damage.
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