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Role of endothelial lipase in anti-inflammatory properties of high-density lipoprotein

Research Project

Project/Area Number 22790705
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKobe University

Principal Investigator

HARA Tetsuya  神戸大学, 大学院・医学研究科, 医学研究員 (70547504)

Research Collaborator ISHIDA Tatsuro  神戸大学, 医学部附属病院, 准教授 (00379413)
HIRATA Ken-ichi  神戸大学, 大学院・医学研究科, 教授 (20283880)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords炎症 / 動脈硬化 / 脂質代謝 / 血管内皮 / リパーゼ / 高比重リポ蛋白質 / 循環器 / 分子血管病態学 / 生活習慣病 / 高比重リポ蛋白
Research Abstract

Inhibition of endothelial lipase(EL) increases plasma high-density lipoprotein cholesterol(HDL-C) level. In this study, we assessed the functional quality of HDL isolated from EL-/-and WT mice. Anti-inflammatory functions of HDL, such as PON-1 or PAF-AH activities, inhibition of cytokine-induced VCAM-1 expression, inhibition of LDL oxidation, were similar between WT and EL-/-mice. In contrast, lipopolysaccharideneutralizing capacity of HDL was higher in EL-/-mice than in WT mice. Intravenous injection of HDL isolated from EL-/-mice improved the mortality in LPS-treated mice. Thus, EL inactivation increased plasma HDL particles with preserved anti-inflammatory and anti-atherosclerotic functions.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (25 results)

All 2012 2011 2010

All Journal Article (13 results) (of which Peer Reviewed: 7 results) Presentation (11 results) Book (1 results)

  • [Journal Article] The Effect of Poloxamer 407 on the Functional Properties of HDL In Mice2012

    • Author(s)
      Yasuda T, Johnston TP, Shinohara M, Inoue M, Ishida T.
    • Journal Title

      J Pharm Pharmacol

      Volume: 64 Pages: 677-87

    • Related Report
      2011 Final Research Report
  • [Journal Article] The Effect of Poloxamer 407 on the Functional Properties of HDL In Mice2012

    • Author(s)
      Yasuda T, et al
    • Journal Title

      J Pharm Pharmacol

      Volume: (In press)(掲載確定)(未定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial Lipase Mediates HDL Levels in Normal and Hyperlipidemic Rabbits2012

    • Author(s)
      Zhang J, et al
    • Journal Title

      J Atheroscler Thromb

      Volume: (In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGD5 Mediates Pro-angiogenic Activity of Vascular Endothelial Growth Factor in Human Vascular Endothelial Cells2012

    • Author(s)
      Kurogane Y, et al
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 32 Pages: 988-996

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted deletion of endothelial lipase increases HDL particles with anti-inflammatory properties both in vitro and in vivo2011

    • Author(s)
      Hara T, Ishida T, Kojima Y, Tanaka H, Yasuda T, Shinohara M, Toh R, Hirata K.
    • Journal Title

      J. Lipid Res

      Volume: 52 Pages: 57-67

    • Related Report
      2011 Final Research Report
  • [Journal Article] Orally Administered Eicosapentaenoic Acid Induces Rapid Regression of Atherosclerosis Via Modulating the Phenotype of Dendritic Cells in LDL Receptor-Deficient Mice2011

    • Author(s)
      Nakajima K, et al
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 31 Pages: 1963-72

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted deletion of endothelial lipase increases HDL particles with anti-inflammatory properties both in vitro and in vivo.2011

    • Author(s)
      Tetsuya Hara, et al.
    • Journal Title

      Journal of lipid Research

      Volume: 52 Pages: 57-67

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rader DJ. Update on the role of endothelial lipase in HDL metabolism, reverse cholesterol transport, and atherosclerosis2010

    • Author(s)
      Yasuda T, Ishida T
    • Journal Title

      Circ J

      Volume: 74 Pages: 2263-70

    • Related Report
      2011 Final Research Report
  • [Journal Article] Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyteendothelial interaction2010

    • Author(s)
      Inoue M, Ishida T, Yasuda T, Toh R, Hara T, Cangara HM, Rikitake Y, Taira K, Sun L, Kundu RK, Quertermous T, Hirata K.
    • Journal Title

      Microvasc Res

      Volume: 80 Pages: 179-87

    • Related Report
      2011 Final Research Report
  • [Journal Article] Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis2010

    • Author(s)
      Cangara HM, Ishida T, Hara T, Sun L, Toh T, Rikitake Y, Kundu RK, Quertermous T, Hirata K, Hayashi Y.
    • Journal Title

      Microvasc Res

      Volume: 80 Pages: 133-41

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pitavastatin decreases expression of endothelial lipase both in vitro and in vivo2010

    • Author(s)
      Kojima Y, Ishida T, Sun L, Yasuda T, Toh T, Rikitake Y, Fukuda A, Kume N, Koshiyama H, Taniguchi A, Hirata K.
    • Journal Title

      Cardiovasc Res

      Volume: 87 Pages: 385-93

    • Related Report
      2011 Final Research Report
  • [Journal Article] Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis2010

    • Author(s)
      Cangara HM, et al.
    • Journal Title

      Microvasc Res.

      Volume: 80 Pages: 133-141

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyte-endothelial interaction.2010

    • Author(s)
      Inoue M, et al.
    • Journal Title

      Microvasc Res.

      Volume: 80 Pages: 179-187

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Establishment of a novel, highsensitive ELISA system for human endothelial lipase2012

    • Author(s)
      Ishida, T, Miyashita, K, Kinoshita, N, Seito, S, Hirata K, Nakajima K.
    • Organizer
      HDL Satellite symposium 2012
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] ESTABLISHMENT OF A NOVEL, HIGH-SENSITIVE ELISA SYSTEM FOR HUMAN ENDOTHELIAL LIPASE2012

    • Author(s)
      Ishida T, et al
    • Organizer
      HDL Satellite symposium 2012
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Plasma mass and activity of endothelial lipase are associated with coronary risk factors in humans2012

    • Author(s)
      Ishida T, Mori T, Sun L, Yasuda T, Hirata K.
    • Organizer
      The XVI International Symposium on Atherosclerosis(ISA2012)
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Cardiac endothelial lipase expression is augmented in the early stage of heart failure2012

    • Author(s)
      Nakajima H, Ishida T, Sasaki M, Kondo K, Mori K, Hasokawa M, Haraguchi Y, Yasuda T, Kobayashi S, Hirata K.
    • Organizer
      The XVI International Symposium on Atherosclerosis(ISA2012)
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Plasma mass and activity of endothelial lipase are associated with coronary risk factors in humans2012

    • Author(s)
      Ishida T, et al
    • Organizer
      The XVI International Symposium on Atherosclerosis
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cardiac endothelial lipase expression is augmented in a murine model of heart failure2012

    • Author(s)
      Nakajima H, et al
    • Organizer
      第76回日本循環器内会総会・学術集会
    • Place of Presentation
      Sydney, Austraria
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cardiac endothelial lipase expression is augmented in a murine model of heart failure2012

    • Author(s)
      Nakajima H, Ishida T, Monguchi T, Sasaki M, Kondo K, Mori K, Hasokawa M, Haraguchi Y, Sun L, Yasuda T, Shinohara M, Toh R, Kobayashi S, Hirata K.
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Cardiac endothelial lipase expression is augmented in a murine model of heart failure2012

    • Author(s)
      Nakajima H, et al
    • Organizer
      第76回日本循環器内会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖尿病性動脈硬化における脂質異常の関与2011

    • Author(s)
      石田達郎, 他
    • Organizer
      第26回日本糖尿病合併症学会総会
    • Place of Presentation
      大宮
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Increased expression of endothelial lipase in a murine model of heart failure2011

    • Author(s)
      Nakajima H, et al
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of endothelial lipase in HDL metabolism and atherosclerosis in humans2011

    • Author(s)
      Ishida T, Toh R, Sun L, Yasuda T, Hirata K.
    • Organizer
      79th European Atherosclerosis Society Congress
    • Place of Presentation
      Gothenburg, Sweden
    • Year and Date
      2011-06-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 血管内皮リパーゼの臨床的意義. Annual Review糖尿病・代謝・内分泌20102010

    • Author(s)
      石田達郎、平田健一
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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