| Project/Area Number |
22790705
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
HARA Tetsuya 神戸大学, 大学院・医学研究科, 医学研究員 (70547504)
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| Research Collaborator |
ISHIDA Tatsuro 神戸大学, 医学部附属病院, 准教授 (00379413)
HIRATA Ken-ichi 神戸大学, 大学院・医学研究科, 教授 (20283880)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 炎症 / 動脈硬化 / 脂質代謝 / 血管内皮 / リパーゼ / 高比重リポ蛋白質 / 循環器 / 分子血管病態学 / 生活習慣病 / 高比重リポ蛋白 |
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| Research Abstract |
Inhibition of endothelial lipase(EL) increases plasma high-density lipoprotein cholesterol(HDL-C) level. In this study, we assessed the functional quality of HDL isolated from EL-/-and WT mice. Anti-inflammatory functions of HDL, such as PON-1 or PAF-AH activities, inhibition of cytokine-induced VCAM-1 expression, inhibition of LDL oxidation, were similar between WT and EL-/-mice. In contrast, lipopolysaccharideneutralizing capacity of HDL was higher in EL-/-mice than in WT mice. Intravenous injection of HDL isolated from EL-/-mice improved the mortality in LPS-treated mice. Thus, EL inactivation increased plasma HDL particles with preserved anti-inflammatory and anti-atherosclerotic functions.
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