Role of angiotensin II type 1 receptor in macrophage polarization and function

• Project/Area Number: 22790707
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Ehime University
• Principal Investigator: SUZUKI Jun 愛媛大学, 大学院・医学系研究科, 講師 (40452693)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: マクロファージ / 動脈硬化 / プラーク破綻 / アンジオテンシンII / 受容体

Research Abstract

Stimulation of the angiotensin II type 1 receptor induces macrophage polarization to inflammatory M1 state and activates macrophage phagocytic function. Angiotensin II type 1 receptor also plays an important role in oxidized LDL-induced macrophage trapping in the atherosclerotic lesions via enhancing CD36 expression and focal adhesion kinase activation. Our results suggest that stimulation of the angiotensin II type 1 receptor modulates macrophage polarity and functions, resulting in atherosclerotic plaque instability.

Research Products

• [Journal Article] Deletion of the Angiotensin II Type 1a Receptor Prevents Atherosclerotic Plaque Rupture (2012)
  • Author(s): Aono J, Suzuki J, Iwai M, Horiuchi M, Nagai T, Nishimura K, Inoue K, Ogimoto A, Okayama H, Higaki J
  • Journal Title: Arterioscle Thromb Vasc Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Deletion of the Angiotensin II Type 1a Receptor Prevents Athero sclerotic Plaque Rupture (2012)
  • Author(s): Jun Aono, Jun Suzuki, et al
  • Journal Title: Arterioscle Thromb Vasc Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] 動脈硬化の進展とレニン・アンジオテンシン系 (2011)
  • Author(s): 青野潤、鈴木純、大木元明義、檜垣實男
  • Journal Title: 愛媛医学 Volume: 30巻 Pages: 86-90
• [Presentation] 動脈硬化性粥腫破綻におけるアンジオテンシンII 1型受容体の役割.動脈硬化性粥腫破綻マウスモデルを用いた検討 (2011)
  • Author(s): 鈴木純、青野潤、大木元明義、岩井將、堀内正嗣、檜垣實男
  • Organizer: 第34回日本高血圧学会総会、高血圧関連疾患モデル学会合同シンポジウム
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-22
• [Presentation] 動脈硬化性粥腫破綻におけるアンジオテンシンII1型受容体の役割～動脈硬化性粥腫破綻マウスモデルを用いた検討 (2011)
  • Author(s): 鈴木純
  • Organizer: 第34回日本高血圧学会総会、高血圧関連疾患モデル学会合同シンポジウム
  • Place of Presentation: 栃木県総合文化センター(栃木県)
  • Year and Date: 2011-10-22
• [Presentation] Deletion of the Angiotensin II Type 1a Receptor Prevents Atherosclerotic Plaque Rupture in Apolipoprotein E^<-/-> Mice (2010)
  • Author(s): Aono J, Suzuki J, Ogimoto A, Okayama H, Iwai M, Horiuchi M, Higaki J
  • Organizer: American Heart Association Scientific Sessions 2010
  • Place of Presentation: シカゴ,アメリカ合衆国
  • Year and Date: 2010-11-17
• [Presentation] Deletion of the Angiotensin II Type Ia Receptor Prevents Atherosclerotic Plaque Rupture (2010)
  • Author(s): Jun Aono
  • Organizer: American Heart Association Scientific Sessions 2010
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2010-11-17