Glial cell dysfunction in the pathogenesis of heart failure

• Project/Area Number: 22790709
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyushu University
• Principal Investigator: KISHI Takuya 九州大学, 大学院・医学研究院, 講師 (70423514)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 心不全 / 交感神経活動 / グリア細胞

Research Abstract

We have demonstrated that oxidative stress in the cardiovascular center of the brainstem contributes to the sympathetic hyperactivity in the pathogenesis of chronic heart failure. In the present study, we have novel new findings, following that the activation of inflammatory cascade mediated by toll-like receptor 4 in the microglia causes sympathetic hyperactivity via apoptosis of astrocyte, which has a protective effect for neuron, in the cardiovascular center of the brainstem of heart failure model rats.

Research Products

• [Presentation] Autoimplantation of Astrocyte into the Cardiovascular Center… (2011)
  • Author(s): Takuya Kishi, et al
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: ニューオーリンズ(米国)
  • Year and Date: 2011-11-22
• [Presentation] Autoimplantation of Astrocytes into the Cardiovascular Center of Brainstem Causes Sympathoinhibition and Decreases the Mortality Rate in Myocardial Infarction-Induced Heart Failure (2011)
  • Author(s): Kishi T, Hirooka Y, Sunagawa K.
  • Organizer: American Heart Association Scientific Sessions2011
  • Place of Presentation: オーランド、米国
  • Year and Date: 2011-11-15
• [Presentation] Autoimplantation of astrocytes into cardiovascular center of brainstem causes sympathoinhibition and decreases the mortality rate in Hypertensive rats (2010)
  • Author(s): Kishi T, Hirooka Y, Sunagawa K.
  • Organizer: The 81th Annual Scientific Meeting of the American Heart Association
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2010-11-15
• [Presentation] Autoimplantation of astrocytes into cardiovascular center of brainstem causes sympathoinhibition and decreases the mortality rate in Hypertensive rats (2010)
  • Author(s): Kishi T.
  • Organizer: AHA International Lunch Forum(Japan)
  • Place of Presentation: オーランド、米国
  • Year and Date: 2010-11-15
• [Presentation] Apoptosis of astrocyte mediated by toll-like receptor 4 in the cardiovascular center causes excessive sympathoexcitation in hypertensive rats (2010)
  • Author(s): Kishi T, Hirooka Y, Sunagawa K.
  • Organizer: The 81th Annual Scientific Meeting of the American Heart Association
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2010-11-15
• [Presentation] Autoimplantation of astrocytes into cardiovascular center of brainstem causes sympathoinhibition and decreases the mortality rate in Hypertensive rats (2010)
  • Author(s): Kishi T, Hirooka Y, Sunagawa K.
  • Organizer: The 19th International Conference of the Cardiovascular System Dynamics Society
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-25