Identification of novel muscle-derived angiogenic factors induced by passive exercise

• Project/Area Number: 22790711
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: IZUMIYA Yasuhiro 熊本大学, 大学院・生命科学研究部, 助教 (10515414)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 臨床心血管病態学 / 受動運動 / 骨格筋 / 分泌因子 / 血管新生

Research Abstract

Whole body periodic acceleration(WBPA) has been developed as a "passive exercise" device to improve endothelial function by increasing shear stress through repetitive movements in spinal axis direction. We investigated the effects of WBPA on blood flow recovery in a mouse model of hindlimb ischemia and in patients with peripheral arterial disease(PAD). WBPA increased blood supply to ischemic lower extremities through activation of eNOS signaling and upregulation of pro-angiogenic growth factor in ischemic skeletal muscle. WBPA is a potentially suitable non-invasive intervention to facilitate therapeutic angiogenesis.

Research Products

• [Journal Article] Akt1-mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial infarction (2012)
  • Author(s): Araki S, Izumiya Y*, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H.
  • Journal Title: Circ Heart Fail Volume: 5 Pages: 116-25
  • Peer Reviewed
• [Journal Article] Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein-E Deficient Mice (2012)
  • Author(s): Matsubara J, Sugiyama S, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, Kurokawa H, Nozaki T, Ohba K, Konishi M, Maeda H, Izumiya Y, Kaikita K, Sumida H, Jinnouchi H, Matsui K, Kim-Mitsuyama S, Takeya M, Ogawa H.
  • Journal Title: J Am Coll Cardiol Volume: 59 Pages: 265-76
  • Peer Reviewed
• [Journal Article] Aktl-mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after epxerimental myocardial infarction (2012)
  • Author(s): Satoshi Araki
  • Journal Title: Circ Heart Fail Volume: 5 Pages: 116-125
  • Peer Reviewed
• [Journal Article] Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein-E Deficient Mice (2012)
  • Author(s): Junichi Matsubara
  • Journal Title: J Am Coll Cardiol Volume: 59 Pages: 265-276
  • Peer Reviewed
• [Journal Article] A fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via an endothelial nitric oxide synthase-dependent mechanism (2012)
  • Author(s): Sonomi Maruyama
  • Journal Title: J Biol Chem Volume: 287 Pages: 408-417
  • Peer Reviewed
• [Journal Article] Passive Exercise Using Whole Body Periodic Acceleration Enhances Blood Supply to Ischemic Hindlimb (2011)
  • Author(s): Rokutanda T, Izumiya Y*, Miura M, Fukuda S, Shimada K, Izumi Y, Nakamura Y, Araki S, Hanatani S, Matsubara J, Nakamura T, Kataoka K, Yasuda O, Kaikita K, Sugiyama S, Kim-Mitsuyama S, Yoshikawa J, Fujita M, Yoshiyama M, Ogawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31 Pages: 2872-80
  • Peer Reviewed
• [Journal Article] Adipolin/C1qdc2/CTRP12 functions as an adipokine that improves glucose metabolism (2011)
  • Author(s): Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N.
  • Journal Title: J Biol Chem Volume: 286 Pages: 34552-8
  • Peer Reviewed
• [Journal Article] Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris (2011)
  • Author(s): Izumiya Y*, Kojima S, Kojima S, Araki S, Usuku H, Matsubara J, Sakamoto K, Tsujita K, Nagayoshi Y, Kaikita K, Sugiyama S, Ogawa H.
  • Journal Title: Atherosclerosis Volume: 214 Pages: 415-21
  • Peer Reviewed
• [Journal Article] Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration, and improves muscle function in dystrophin-deficient mdx mice (2011)
  • Author(s): Kim MH, Kay DI, Rudra RT, Chen BM, Hsu N, Izumiya Y, Martinez L, Spencer MJ, Walsh K, Grinnell A, Crosbie RH.
  • Journal Title: Hum Mol Gene Volume: 20 Pages: 1324-38
  • Peer Reviewed
• [Journal Article] Passive Exercise Using Whole Body Periodic Acceleration Enhances Blood Supply to Ischemic Hindlimb (2011)
  • Author(s): Taku Rokutanda
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31 Pages: 2872-2880
  • Peer Reviewed
• [Journal Article] Adipolin/C1qdc2/CTRP12 functions as an adipokine that improves glucose metabolism (2011)
  • Author(s): Takashi Enomoto
  • Journal Title: J Biol Chem Volume: 286 Pages: 34552-34558
  • Peer Reviewed
• [Journal Article] Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris (2011)
  • Author(s): Yasuhiro Izumiya
  • Journal Title: Atherosclerosis. Volume: 214 Pages: 415-21
  • Peer Reviewed
• [Journal Article] Myogenic Alit signaling attenuates muscular degeneration, promotes myofiber regeneration, and improves muscle function in dystrophin-deficient mdx mice. (2011)
  • Author(s): Michelle H.Kim
  • Journal Title: Hum Mol Genet. Volume: 20(7) Pages: 1324-38
  • Peer Reviewed
• [Journal Article] Insulin-like 6 is induced by muscle injury and functions as a regenerative factor (2010)
  • Author(s): Zeng L, Akasaki Y, Sato K, Ouchi N, Izumiya Y, Walsh K.
  • Journal Title: J Biol Chem Volume: 285 Pages: 36060-9
  • Peer Reviewed
• [Journal Article] Digital assessment of endothelial function and ischemic heart disease in women (2010)
  • Author(s): Matsuzawa Y, Sugiyama S, Sugamura K, Nozaki T, Ohba K, Konishi M, Matsubara J, Sumida H, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Iwashita S, Matsui K, Jinnouchi H, Kimura K, Umemura S, Ogawa H.
  • Journal Title: J Am Coll Cardiol Volume: 55 Pages: 1688-96
  • Peer Reviewed
• [Journal Article] Insulin-like 6 is induced by muscle injury and functions as a regenerative factor. (2010)
  • Author(s): Ling Zeng
  • Journal Title: J Biol Chem. Volume: 285(46) Pages: 36060-9
  • Peer Reviewed
• [Journal Article] Digital assessment of endothelial function and ischemic heart disease in women. (2010)
  • Author(s): Yasushi Matsuzawa
  • Journal Title: J Am Coll Cardiol. Volume: 55(16) Pages: 1688-96
  • Peer Reviewed
• [Presentation] Akt1-Mediated Skeletal Muscle Growth Promotes Capillary Growth in the Myocardium and Attenuates Cardiac Remodeling in a Murine Myocardial Infarction Model (2012)
  • Author(s): 泉家康宏
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡国際会議場,福岡
  • Year and Date: 2012-03-16
• [Presentation] 全身加速ベッドによる受動運動は末梢動脈疾患患者の下肢血流を改善する (2011)
  • Author(s): 六反田拓
  • Organizer: 日本循環器学会九州地方会、YIAセッション
  • Place of Presentation: アクロス福岡国際会議場福岡県
  • Year and Date: 2011-12-03
• [Presentation] Whole Body Periodic Acceleration, Novel Passive Exercise Devices, Enhances Blood Supply to Ischemic Hindlimb in Mice and Human (2011)
  • Author(s): Taku rokutanda
  • Organizer: American Heart Association Scientific Session 2011
  • Place of Presentation: Orange County Convention Center, Orlando, USA
  • Year and Date: 2011-11-15
• [Presentation] Sirt7 Deficiency Impairs Angiogenic Responses in a Mouse Model of Vascular Insufficiency (2011)
  • Author(s): 泉家康宏
  • Organizer: American Heart Association Scientific Session 2011
  • Place of Presentation: Orange County Convention Center Orlando, USA.
  • Year and Date: 2011-11-13
• [Presentation] Sirt7 Deficiency Impaires Angiogenic Responses in a Mouse Model of Vascular Insufficiency (2011)
  • Author(s): Yasuhiro Izumiya
  • Organizer: American Heart Association Scientific Session 2011
  • Place of Presentation: Orange County Convention Center, Orlando, USA
  • Year and Date: 2011-11-13
• [Presentation] Akt1-Mediated Skeletal Muscle Growth Attenuates Cardiac Dysfunction and Remodeling after Experimental Myocardial Infarction (2011)
  • Author(s): 泉家康宏
  • Organizer: 第15回日本心不全学会・学術集会
  • Place of Presentation: かごしま県民交流センター,鹿児島
  • Year and Date: 2011-10-13
• [Presentation] Passive Exercise Using Whole Body Periodic Acceleration Device Promotes Angiogenesis in a Mice Model of Hindlimb Ischemia (2010)
  • Author(s): Taku Rokutanda
  • Organizer: American Heart Association Scientific Session 2010
  • Place of Presentation: (Chicago, USA) McCormick Place
  • Year and Date: 2010-11-15