Research Project
Grant-in-Aid for Young Scientists (B)
Whole body periodic acceleration(WBPA) has been developed as a "passive exercise" device to improve endothelial function by increasing shear stress through repetitive movements in spinal axis direction. We investigated the effects of WBPA on blood flow recovery in a mouse model of hindlimb ischemia and in patients with peripheral arterial disease(PAD). WBPA increased blood supply to ischemic lower extremities through activation of eNOS signaling and upregulation of pro-angiogenic growth factor in ischemic skeletal muscle. WBPA is a potentially suitable non-invasive intervention to facilitate therapeutic angiogenesis.
All 2012 2011 2010
All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (7 results)
Circ Heart Fail
Volume: 5 Pages: 116-25
J Am Coll Cardiol
Volume: 59 Pages: 265-76
Volume: 5 Pages: 116-125
Volume: 59 Pages: 265-276
J Biol Chem
Volume: 287 Pages: 408-417
Arterioscler Thromb Vasc Biol
Volume: 31 Pages: 2872-80
Volume: 286 Pages: 34552-8
Atherosclerosis
Volume: 214 Pages: 415-21
Hum Mol Gene
Volume: 20 Pages: 1324-38
Volume: 31 Pages: 2872-2880
Volume: 286 Pages: 34552-34558
Atherosclerosis.
Hum Mol Genet.
Volume: 20(7) Pages: 1324-38
Volume: 285 Pages: 36060-9
Volume: 55 Pages: 1688-96
J Biol Chem.
Volume: 285(46) Pages: 36060-9
J Am Coll Cardiol.
Volume: 55(16) Pages: 1688-96