Identification of novel muscle-derived angiogenic factors induced by passive exercise
| Project/Area Number |
22790711
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
IZUMIYA Yasuhiro 熊本大学, 大学院・生命科学研究部, 助教 (10515414)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 臨床心血管病態学 / 受動運動 / 骨格筋 / 分泌因子 / 血管新生 |
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| Research Abstract |
Whole body periodic acceleration(WBPA) has been developed as a "passive exercise" device to improve endothelial function by increasing shear stress through repetitive movements in spinal axis direction. We investigated the effects of WBPA on blood flow recovery in a mouse model of hindlimb ischemia and in patients with peripheral arterial disease(PAD). WBPA increased blood supply to ischemic lower extremities through activation of eNOS signaling and upregulation of pro-angiogenic growth factor in ischemic skeletal muscle. WBPA is a potentially suitable non-invasive intervention to facilitate therapeutic angiogenesis.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein-E Deficient Mice2012
Author(s)
Matsubara J, Sugiyama S, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, Kurokawa H, Nozaki T, Ohba K, Konishi M, Maeda H, Izumiya Y, Kaikita K, Sumida H, Jinnouchi H, Matsui K, Kim-Mitsuyama S, Takeya M, Ogawa H.
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Journal Title
J Am Coll Cardiol
Volume: 59
Pages: 265-76
Related Report
Peer Reviewed
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[Journal Article] Passive Exercise Using Whole Body Periodic Acceleration Enhances Blood Supply to Ischemic Hindlimb2011
Author(s)
Rokutanda T, Izumiya Y*, Miura M, Fukuda S, Shimada K, Izumi Y, Nakamura Y, Araki S, Hanatani S, Matsubara J, Nakamura T, Kataoka K, Yasuda O, Kaikita K, Sugiyama S, Kim-Mitsuyama S, Yoshikawa J, Fujita M, Yoshiyama M, Ogawa H.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 31
Pages: 2872-80
Related Report
Peer Reviewed
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[Journal Article] Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris2011
Author(s)
Izumiya Y*, Kojima S, Kojima S, Araki S, Usuku H, Matsubara J, Sakamoto K, Tsujita K, Nagayoshi Y, Kaikita K, Sugiyama S, Ogawa H.
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Journal Title
Atherosclerosis
Volume: 214
Pages: 415-21
Related Report
Peer Reviewed
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[Journal Article] Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration, and improves muscle function in dystrophin-deficient mdx mice2011
Author(s)
Kim MH, Kay DI, Rudra RT, Chen BM, Hsu N, Izumiya Y, Martinez L, Spencer MJ, Walsh K, Grinnell A, Crosbie RH.
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Journal Title
Hum Mol Gene
Volume: 20
Pages: 1324-38
Related Report
Peer Reviewed
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[Journal Article] Digital assessment of endothelial function and ischemic heart disease in women2010
Author(s)
Matsuzawa Y, Sugiyama S, Sugamura K, Nozaki T, Ohba K, Konishi M, Matsubara J, Sumida H, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Iwashita S, Matsui K, Jinnouchi H, Kimura K, Umemura S, Ogawa H.
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Journal Title
J Am Coll Cardiol
Volume: 55
Pages: 1688-96
Related Report
Peer Reviewed
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