Plaque REgression with Cholesterol absorption Inhibitor or Synthesis inhibitor Evaluated by IntraVascular UltraSound

• Project/Area Number: 22790713
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: TSUJITA Kenichi 熊本大学, 医学部附属病院, 助教 (60571263)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 臨床心血管病態学 / コレステロール吸収阻害薬 / 冠動脈プラーク退縮

Research Abstract

Based on the study protocol, 250 cases(including protocol I and II) have been enrolled from Kumamoto University and collaborating centers. Coronary angiography(CAG) and intravascular ultrasound(IVUS) images were collected to our core laboratory, quantitative CAG and IVUS analysis was done. Interim analysis revealed that low incidence of drug adverse reaction, greater lowering effect of low-density lipoprotein cholesterol, and equivalent or greater plaque regression effect in atorvastatin+ezetimibe group than in atorvastatin alone group.

Research Products

• [Journal Article] Premenopausal woman with acute myocardial infarction caused by spontaneous coronary artery dissection and potential association with coronary vasospasm (2012)
  • Author(s): Tsujita K, Miyazaki T, Kaikita K, Chitose T, Takaoka N, Soejima H, Tayama S, Hokimoto S, Sugiyama S, Ogawa H.
  • Journal Title: Cardiovasc Interv and Ther Volume: 27 Issue: 2 Pages: 121-126
  • DOI: 10.1007/s12928-011-0094-8
  • NAID: 40019281732
  • Peer Reviewed
• [Journal Article] A survival case of cardiogenic shock due to left main coronary artery myocardial infarction : successful cooperation with on-site percutaneous coronary intervention and helicopter emergency medical service (2012)
  • Author(s): Kimura Y, Oba K, Sumida H, Tsujita K, Hirose T, Maruyama H, Hirai S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
  • Journal Title: Intern Med
  • NAID: 130002062239
  • Peer Reviewed
• [Journal Article] Subsequent silent plaque rupture of nonculprit lesion in a patient with acute myocardial infarction (2012)
  • Author(s): Takaoka N, Tsujita K, Kaikita K, Tayama S, Hokimoto S, Sugiyama S, Ogawa H.
  • Journal Title: Int J Cardiol Volume: 157
  • Peer Reviewed
• [Journal Article] Ribosomal protein S19 is present in plasma as a complex with prothrombin (2011)
  • Author(s): Nishiura, H., Tanase, S., Tsujita, K., Sugiyama, S., Ogawa, ・H., Nakagaki, T., Semba, U., and Yamamoto, T.
  • Journal Title: Eur. J. Haematol. Volume: 86 Issue: 5 Pages: 436-441
  • DOI: 10.1111/j.1600-0609.2011.01585.x
  • Peer Reviewed
• [Journal Article] C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation (2011)
  • Author(s): Yuji Miyazaki
  • Journal Title: Arterioscler.Thromb.Vasc.Biol. Volume: 31 Issue: 5 Pages: 1124-1132
  • DOI: 10.1161/atvbaha.111.224519
  • Peer Reviewed
• [Journal Article] Current status and prospects of antiplatelet therapy in percutaneous coronary intervention in Japan : focus on adenosine diphosphate receptor inhibitors (2011)
  • Author(s): Ogawa H, Hokimoto S, Kaikita K, Yamaoto K, Chitose T, Ono T, Tsujita K.
  • Journal Title: J Cardiol Volume: 58 Issue: 1 Pages: 6-17
  • DOI: 10.1016/j.jjcc.2011.03.002
  • NAID: 10031159568
  • Peer Reviewed
• [Journal Article] In vivo intravascular ultrasound imaging of fibromuscular dysplastic region and intravascular pressure gradient-guided percutaneous transluminal renal angioplasty (2011)
  • Author(s): Onoue Y, Tsujita K, Hokimoto S, Kaikita K, Sugiyama S, Ogawa H.
  • Journal Title: JC Cases Volume: 4 Issue: 3 Pages: e163-e167
  • DOI: 10.1016/j.jccase.2011.08.006
  • NAID: 120004853376
  • Peer Reviewed
• [Journal Article] Determination of cut-off levels for on-clopidogrel platelet aggregation based on functional CYP2C19 gene variants in patients undergoing elective percutaneous coronary intervention (2011)
  • Author(s): Ono T, Kaikita K, Hokimoto S, Iwashita S, Yamamoto K, Miyazaki Y, Horio E, Sato K, Tsujita K, Abe T, Deguchi M, Tayama S, Sumida H, Sugiyama S, Yamabe H, Nakamura S, Nakagawa K, Ogawa H.
  • Journal Title: Thromb Res Volume: 128 Issue: 6 Pages: e130-e136
  • DOI: 10.1016/j.thromres.2011.07.028
  • Peer Reviewed
• [Journal Article] Impact of CYP2C19 polymorphism on residual platelet reactivity in patients with coronary heart disease during antiplatelet therapy (2011)
  • Author(s): Yamamoto K, Hokimoto S, Chitose T, Morita K, Ono T, Kaikita K, Tsujita K, Abe T, Deguchi M, Miyagawa H, Saruwatari J, Sumida H, Sugiyama S, Nakagawa K, Ogawa H.
  • Journal Title: J Cardiol Volume: 57 Issue: 2 Pages: 194-201
  • DOI: 10.1016/j.jjcc.2010.10.007
  • NAID: 10031159562
  • Peer Reviewed
• [Journal Article] Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris (2011)
  • Author(s): Izumiya Y, Kojima S, Kojima S, Araki S, Usuku H, Matsubara J, Sakamoto K, Tsujita K, Nagayoshi Y, Kaikita K, Sugiyama S, Ogawa H.
  • Journal Title: Atherosclerosis Volume: 214 Issue: 2 Pages: 415-421
  • DOI: 10.1016/j.atherosclerosis.2010.11.032
  • Peer Reviewed
• [Journal Article] Determination of cut-off levels for on-clopidogrel platelet aggregation based on functional CYP2C19 gene variants in patients undergoing elective percutaneous coronary intervention (2011)
  • Author(s): Ono T, Kaikita K, Hokimoto S, Iwashita S, Yamamoto K, Miyazaki Y, Horio E, Sato K, Tsujita K, Abe T, Deguchi M, Tayama S, Sumida H, Sugiyama S, Yamabe H, Nakamura S, Nakagawa K, Ogawa H
  • Journal Title: Thromb Res Volume: 128
  • Peer Reviewed
• [Journal Article] Subsequent silent plaque rupture of nonculprit lesion in a patient with acute myocardial infarction (2011)
  • Author(s): Takaoka N, Tsujita K, Kaikita K, Tayama S, Hokimoto S, Sugiyama S, Ogawa H
  • Journal Title: Int J Cardiol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris. (2011)
  • Author(s): Izumiya Y, Kojima S, Kojima S, Araki S, Usuku H, Matsubara J, Sakamoto K, Tsujita K, Nagayoshi Y, Kaikita K, Sugiyama S, Ogawa H.
  • Journal Title: Atherosclerosis Volume: 214巻 Pages: 415-421
  • Peer Reviewed
• [Journal Article] Serial intravascular ultrasound analysis of the impact of myocardial bridge on neointimal proliferation after coronary stenting in patients with acute myocardial infarction (2010)
  • Author(s): Tsujita K, Maehara A, Mintz GS, Lansky AJ, Kubo T, Doi H, Yang J, Bharaj H, Witzenbichler B, Guagliumi G, Brodie BR, Kellett MA, Jr., Parise H, Mehran R, Stone GW.
  • Journal Title: J Interv Cardiol Volume: 23 Issue: 2 Pages: 114-122
  • DOI: 10.1111/j.1540-8183.2010.00531.x
  • Peer Reviewed
• [Journal Article] Impact of anemia on clinical outcomes of patients with ST-segment elevation myocardial infarction in relation to gender and adjunctive antithrombotic therapy(from the HORIZONS-AMI trial) (2010)
  • Author(s): Tsujita K, Nikolsky E, Lansky AJ, Dangas G, Fahy M, Brodie BR, Dudek D, Mockel M, Ochala A, Mehran R, Stone GW.
  • Journal Title: Am J Cardiol Volume: 105 Issue: 10 Pages: 1385-1394
  • DOI: 10.1016/j.amjcard.2010.01.001
  • Peer Reviewed
• [Journal Article] Prognostic value of plasma von Willebrand factor-cleaving protease(ADAMTS13) antigen levels in patients with coronary artery disease (2010)
  • Author(s): Miura M, Kaikita K, Matsukawa M, Soejima K, Fuchigami S, Miyazaki Y, Ono T, Uemura T, Tsujita K, Hokimoto S, Sumida H, Sugiyama S, Matsui K, Yamabe H, Ogawa H.
  • Journal Title: Thromb Haemost Volume: 103 Issue: 03 Pages: 623-629
  • DOI: 10.1160/th09-08-0568
  • Peer Reviewed
• [Journal Article] Intravascular ultrasound classification of plaque distribution in left main coronary artery bifurcations. Where is the plaque really located (2010)
  • Author(s): Oviedo C, Maehara A, Mintz GS, Araki H, Choi SY, Tsujita K, Kubo H, Doi H, Templin B, Lansky AJ, Dangas G, Leon MB, Mehran R, Tahk SJ, Stone GW, Ochiai M, Moses JW.
  • Journal Title: Circ Cardiovasc Interv Volume: 3 Issue: 2 Pages: 105-112
  • DOI: 10.1161/circinterventions.109.906016
  • Peer Reviewed
• [Journal Article] Dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization (2010)
  • Author(s): Kubo T, Maehara A, Mintz GS, Doi H, Tsujita K, Choi SY, Katoh O, Nasu K, Koenig A, Pieper M, Rogers JH, Wijns W, Bose D, Margolis MP, Moses JW, Stone GW, Leon MB.
  • Journal Title: J Am Coll Cardiol Volume: 55 Issue: 15 Pages: 1590-1597
  • DOI: 10.1016/j.jacc.2009.07.078
  • Peer Reviewed
• [Journal Article] Intravascular ultrasound findings of stent fractures in patients with Sirolimus-and Paclitaxel-eluting stents (2010)
  • Author(s): Doi H, Maehara A, Mintz GS, Tsujita K, Kubo T, Castellanos C, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA Jr, Parise H, Mehran R, Leon MB, Moses JW, Stone GW.
  • Journal Title: Am J Cardiol Volume: 106 Issue: 7 Pages: 952-957
  • DOI: 10.1016/j.amjcard.2010.05.024
  • Peer Reviewed
• [Journal Article] Is accurate intravascular ultrasound evaluation of the left circumflex ostium from a left anterior descending to left main pullback possible (2010)
  • Author(s): Oviedo C, Maehara A, Mintz GS, Tsujita K, Kubo T, Doi H, Castellanos C, Lansky AJ, Mehran R, Dangas G, Leon MB, Stone GW, Templin B, Araki H, Ochiai M, Moses JW.
  • Journal Title: Am J Cardiol Volume: 105 Issue: 7 Pages: 948-954
  • DOI: 10.1016/j.amjcard.2009.11.029
  • Peer Reviewed
• [Journal Article] Serial intravascular ultrasound analysis of the impact of myocardial bridge on neointimal proliferation after coronary stenting in patients with acute myocardial infarction. (2010)
  • Author(s): Tsujita K, Maehara A, Mintz GS, Lansky AJ, Kubo T, Doi H, Yang J, Bharaj H, Witzenbichler B, Guagliumi G, Brodie BR, Kellett MA Jr, Parise H, Mehran R, Stone GW.
  • Journal Title: J Interv Cardiol Volume: 23巻 Pages: 114-122
  • Peer Reviewed
• [Journal Article] Impact of anemia on clinical outcomes of patients with ST-segment elevation myocardial infarction in relation to gender and adjunctive antithrombotic therapy (from the HORIZONS-AMI trial). (2010)
  • Author(s): Tsujita K, Nikolsky E, Lansky AJ, Dangas G, Fahy M, Brodie BR, Dudek D, Mockel M, Ochala A, Mehran R, Stone GW.
  • Journal Title: Am J Cardiol Volume: 105巻 Pages: 1385-1394
  • Peer Reviewed
• [Presentation] IVUS-based tissue characterization in clinical setting -VH-IVUS and iMap (2012)
  • Author(s): Tsujita K
  • Organizer: Konyang Mayo Tokyo Meeting 2012
  • Place of Presentation: 建陽(Konyang)、大韓民国(invited lecture)(招待講演)
  • Year and Date: 2012-02-25
• [Presentation] Impact of Cytochrome P450 3A5 Polymorphism on Platelet Aggregation on Maintenance Treatment with Clopidogrel in Patients Undergoing Elective Coronary Stenting (2012)
  • Author(s): Chitose T, Hokimoto S, Mizobe M, Yamamoto K, Ono T, Tsujita K, Tayama S, Kaikita K, Nakagawa K, Ogawa H.
  • Organizer: 61st American College of Cardiology Scientific Sessions
  • Place of Presentation: Chicago, IL, USA
• [Presentation] The Impact of CYP2C19 Polymorphism on Coronary Artery Spasm in Patients with Vasospastic Angina (2012)
  • Author(s): Mizobe M, Hokimoto S, Chitose T, Takaoka N, Tsujita K, Kaikita K, Kazuko N, Ogawa H.
  • Organizer: 61st American College of Cardiology Scientific Sessions
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Intravascular Ultrasound Morphology of Culprit Lesions and Clinical Demographics in Patients With Acute Coronary Syndrome in Relation to Low-Density Lipoprotein Cholesterol Levels at Onset (2012)
  • Author(s): Tsujita K, Takaoka N, Kaikita K, Hokimoto S, Chitose T, Ono T, Mizobe M, Horio E, Sato K, Nakayama N, Tayama S, Sugiyama S, Nakamura S, Ogawa H.
  • Organizer: 61st American College of Cardiology Scientific Sessions
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Acetylcholine-provoked D iffuse Coronary Spasm is Frequently Observed in Female Patients with Coronary Vasospastic Angina without Severe Coronary Organic Stenosis (2012)
  • Author(s): Kaikita K, Sato K, Horio E, Ono T, Ohba K, Tsujita K, Hokimoto S, Sugiyama S, Yamabe H, Ogawa H.
  • Organizer: 76th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Do We Have to Change the Type or Dose of Antiplatelet Agent According to CYP2C19 or 3A5 Genotypes (2012)
  • Author(s): Hokimoto S, Mizobe M, Chitose T, Tsujita K, Kaikita K, Nakagawa K, Ogawa H.
  • Organizer: 76th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka, Japan
• [Presentation] The Outcomes of the Dominance of Cross over Strategy for the Un-protected Left Main Coronary Artery (2012)
  • Author(s): Tayama S, Kaikita K, Hokimoto S, Tsujita K, Sugiyama S, Tanaka T, Nakamura S, Ogawa H.
  • Organizer: 76th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Intravascular Ultrasound Morphology of Culprit Lesions and Clinical Demographics in Patients With Acute Coronary Syndrome in Relation to Low-Density Lipoprotein Cholesterol Levels at Onset (2012)
  • Author(s): Tsujita K, Takaoka N, Kaikita K, Hokimoto S, Chitose T, Ono T, Mizobe M, Horio E, Sato K, Nakayama N, Tayama S, Sugiyama S, Nakamura S, Ogawa H
  • Organizer: American College of Cardiology 2012
  • Place of Presentation: シカゴ、米国
• [Presentation] The Impact of CYP2C19 Polymorphism on Coronary Artery Spasm in Patients with Vasospastic Angina (2012)
  • Author(s): Mizobe M, Hokimoto S, Chitose T, Takaoka N, Tsujita K, Kaikita K, Kazuko N, Ogawa H
  • Organizer: American College of Cardiology 2012
  • Place of Presentation: シカゴ、米国
• [Presentation] Impact of Cytochrome P450 3A5 Polymorphism on Platelet Aggregation on Maintenance Treatment with Clopidogrel in Patients Undergoing Elective Coronary Stenting (2012)
  • Author(s): Chitose T, Hokimoto S, Mizobe M, Yamamoto K, Ono T, Tsujita K, Tayama S, Kaikita K, Nakagawa K, Ogawa H
  • Organizer: American College of Cardiology 2012
  • Place of Presentation: シカゴ、米国
• [Presentation] 腹腔鏡手術後のショックを集学的治療により救命しえた心アミロイドーシスの一例 (2011)
  • Author(s): 尾上喜郎, 泉家康宏, 小野敬道, 森久健二, 辻田賢一, 山本英一郎, 山室惠, 海北幸一, 田山信至, 掃本誠治, 角田等, 杉山正悟, 小川久雄
  • Organizer: 日本循環器学会九州地方会
  • Place of Presentation: アクロス福岡、福岡
  • Year and Date: 2011-06-25
• [Presentation] 後天性左心疾患による二次性肺高血圧症に対しシルディナフィルを導入し、症状が軽快した一例 (2011)
  • Author(s): 中嶋梨沙, 小野敬道, 森久健二, 山本英一郎, 辻田賢一, 山室惠, 田中朋子, 田山信至, 海北幸一, 掃本誠治, 角田等, 杉山正悟, 小川久雄
  • Organizer: 日本循環器学会九州地方会
  • Place of Presentation: アクロス福岡、福岡
  • Year and Date: 2011-06-25
• [Presentation] Left Main Plaque Distribution and Stenting Strategy-Insights from Intravascular Ultrasound- (2011)
  • Author(s): Tsujita K.
  • Organizer: Konyang Mayo Tokyo Meeting 2011
  • Place of Presentation: Konyang, Korea(invited lecture)
  • Year and Date: 2011-03-12
• [Presentation] Left Main Plaque Distribution and Stenting Strategy-Insights from Intravascular Ultrasound (2011)
  • Author(s): Tsujita K
  • Organizer: KMT Meeting 2011
  • Place of Presentation: Konyang University Hospital, Deajeon, Korea(招待講演)
  • Year and Date: 2011-03-12
• [Presentation] 様々なリスクファクターにより、若年で発症した心筋梗塞の1例 (2011)
  • Author(s): 時津孝典, 千年忠祐, 辻田賢一, 山室恵, 田山信至, 海北幸一, 掃本誠治, 角田等, 杉山正悟, 小川久雄
  • Organizer: 第292回日本内科学会九州地方会例会
  • Place of Presentation: 九州大学医学部百年講堂(福岡県)
  • Year and Date: 2011-01-29
• [Presentation] Impact of CYP2C19 Polymorphism on In-Stent Restenosis in Patients With Drug-Eluting Stent Implantation. Circulation 2011 ; 124 : A12690 (2011)
  • Author(s): Hokimoto S, Mizobe M, Chitose T, Tsujita K, Kaikita K, Nakagawa K, Ogawa H.
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, FL, USA
• [Presentation] Neointimal Tissue Component Assessed by Tissue Characterization With 40MHz Intravascular Ultrasound Imaging-Comparison of Drug-Eluting Stents and Bare-Metal Stents Circulation 2011 ; 124 : A12690. (2011)
  • Author(s): Tsujita K, Takaoka N, Kaikita K, Hokimoto S, Ono T, Chitose T, Horio E, Sato K, Mizobe M, Nakayama N, Saito M, Tayama S, Sugiyama S, Yamabe H, Nakamura S, Ogawa H.
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, FL, USA
• [Presentation] Acetylcholine-Provoked Diffuse Coronary Spasm is Frequently Observed in Female Patients with Coronary Vasospastic Angina Without Severe Coronary Organic Stenosis. Circulation 2011 ; 124 : A9683 (2011)
  • Author(s): Sato K, Kaikita K, Nakayama N, Horio E, Ono T, Ohba K, Tsujita K, Hokimoto S, Sumida H, Sugiyama S, Yamabe H, Ogawa H.
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, FL, USA
• [Presentation] Angiopoietin-Like Protein2(angptl2)-Induced Vascular Inflammation Causes the Progression of Endothelial Dysfunction and Atherosclerosis. Circulation 2011 ; 124 : A12277 (2011)
  • Author(s): Horio E, Kaikita K, Miyata K, Kadomatsu T, Tazume H, Zhe T, Miyazaki Y, Ono T, Sato K, Tsujita K, Tayama S, Hokimoto S, Sugiyama S, Hao H, Takeya M, Ogawa H, Oike Y.
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, FL, USA
• [Presentation] Coronary Plaque Component in Patients with Vasospastic Angina : A Virtual Histology Intravascular Ultrasound Study. Circulation 2011 ; 124 : A15157 (2011)
  • Author(s): Tsujita K, Sakamoto K, Kojima S, Kojima S, Nagayoshi Y, Sakamoto T, Tayama S, Kaikita K, Hokimoto S, Sumida H, Sugiyama S, Ogawa H.
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, FL, USA
• [Presentation] Impact of CYP2C19 Polymorphism on Development of Acute Coronary Syndrome(ACS) in Patients with Decreased Plasma Low-Density Lipoprotein Cholesterol(LDL-C). J Am Coll Cardiol 2011 ; 57 : E935 (2011)
  • Author(s): Chitose T, Hokimoto S, Yamamoto K, Ono T, Tsujita K, Kaikita K, Sumida H, Sugiyama S, Ogawa H.
  • Organizer: 60th American College of Cardiology Scientific Sessions
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Determination of Optimal Cut-Off Value in On-Clopidogrel Platelet Aggregation by VerifyNow P2Y12 System Based on Functional CYP2C19 Gene Variants. J Am Coll Cardiol 2011 ; 57 : E1146 (2011)
  • Author(s): Ono T, Kaikita K, Hokimoto S, Yamamoto K, Miyazaki Y, Sakamoto K, Tsujita K, Iwashita S, Sumida H, Sugiyama S, Yamabe H, Ogawa H.
  • Organizer: 60th American College of Cardiology Scientific Sessions
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Fibromuscular Dysplasia of Renal Artery : Percutaneous Revascularization Based on Intravascular Ultrasound-Derived Tissue Characterization and Intravascular Pressure Measurement (2011)
  • Author(s): Tsujita K, Onoue Y, Hokimoto S, Kaikita K, Tayama S, Sumida H, Sugiyama S, Nakamura S, Ogawa H
  • Organizer: 第20回日本心血管インターペンション治療学会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] Impact of CYP2C19 Polymorphism on In-Stent Restenosis in Patients With Drug-Eluting Stent Implantation (2011)
  • Author(s): Hokimoto S, Mizobe M, Chitose T, Tsujita K, Kaikita K, Nakagawa K, Ogawa H
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: オーランド、米国
• [Presentation] Neointimal Tissue Component Assessed by Tissue Characterization With 40MHz Intravascular Ultrasound Imaging-Comparison of Drug-Eluting Stents and Bare-Metal Stents (2011)
  • Author(s): Tsujita K, Takaoka N, Kaikita K, Hokimoto S, Ono T, Chitose T, Horio E, Sato K, Mizobe M, Nakayama N, Saito M, Tayama S, Sugiyama S, Yamabe H, Nakamura S, Ogawa H
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: オーランド、米国
• [Presentation] Acetylcholine-Provoked Diffuse Coronary Spasm is Frequently Observed in Female Patients with Coronary Vasospastic Angina Without Severe Coronary Organic Stenosis (2011)
  • Author(s): Sato K, Kaikita K, Nakayama N, Horio E, Ono T, Ohba K, Tsujita K, Hokimoto S, Sumida H, Sugiyama S, Yamabe H, Ogawa H
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: オーランド、米国
• [Presentation] Coronary Plaque Component in Patients with Vasospastic Angina : A Virtual Histology Intravascular Ultrasound Study (2011)
  • Author(s): Tsujita K, Sakamoto K, Kojima S, Kojima S, Nagayoshi Y, Sakamoto T, Tayama S, Kaikita K, Hokimoto S, Sumida H, Sugiyama S, Ogawa H
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: オーランド、米国
• [Presentation] Angiopoietin-Like Protein2 (angptl2)-Induced Vascular Inflammation Causes the Progression of Endothelial Dysfunction and Atherosclerosis (2011)
  • Author(s): Horio E, Kaikita K, Miyata K, Kadomatsu T, Tazume H, Zhe T, Miyazaki Y, Ono T, Sato K, Tsujita K, Tayama S, Hokimoto S, Sugiyama S, Hao H, Takeya M, Ogawa H, Oike Y
  • Organizer: 84th American Heart Association Scientific Sessions
  • Place of Presentation: オーランド、米国
• [Presentation] 左冠動脈主幹部におけるプラーク分布と治療戦略 (2010)
  • Author(s): 辻田賢一, 田山信至, 海北幸一, 掃本誠治, 角田等, 杉山正悟, 中村淳, 小川久雄
  • Organizer: 第24回日本冠疾患学会学術集会
  • Place of Presentation: 東京ステーションカンファレンス(東京)(招待講演)
  • Year and Date: 2010-12-11
• [Presentation] Plaque Distribution in Left Main Trunk and Treatment Strategy (2010)
  • Author(s): Tsujita K, Tayama S, Kaikita K, Hokimoto S, Sumida H, Sugiyama S, Nakamura S, Ogawa H.
  • Organizer: 24th Japanese Coronary Association
  • Place of Presentation: Tokyo, Japan(invited lecture)
  • Year and Date: 2010-12-10
• [Presentation] 待機的冠動脈インターベンション施行例におけるVerifyNow P2Y12システムを用いた至適抗血小板療法 (2010)
  • Author(s): 小野敬道, 海北幸一, 山本浩一郎, 千年忠祐, 辻田賢一, 掃本誠治, 田山信至, 角田等, 杉山正悟, 山部浩茂, 小川久雄
  • Organizer: 第109回日本循環器学会九州地方会
  • Place of Presentation: 長崎ブリックホール(長崎東)
  • Year and Date: 2010-12-04
• [Presentation] On Site PCI、ドクターヘリを用いた病院連携、残存枝へのPCI・集学的治療にて救命し得たLMT AMIの一例 (2010)
  • Author(s): 木村優一, 大庭圭介, 角田等, 高潮征爾, 秋山英一, 千年忠祐, 小野敬道, 山本浩一郎, 野崎俊光, 森久健二, 山本英一郎, 辻田賢一, 山室恵, 泉家康宏, 海北幸一, 掃本誠治, 田山信至, 杉山正悟, 小川久雄, 廣瀬豊樹, 丸山英樹
  • Organizer: 第109回日本循環器学会九州地方会
  • Place of Presentation: 長崎ブリックホール(長崎県)
  • Year and Date: 2010-12-04
• [Presentation] 吸引腫瘍生検にて組織診断に至り、化学療法で著名な改善を得た転移性右房腫瘍の一例 (2010)
  • Author(s): 時津孝典, 山室恵, 海北幸一, 森久健二, 山本英一郎, 辻田賢一, 泉家康宏, 田山信至, 掃本誠治, 角田等, 杉山正悟, 小川久雄
  • Organizer: 第109回日本循環器学会九州地方会
  • Place of Presentation: 長崎ブリックホール(長崎県)
  • Year and Date: 2010-12-04
• [Presentation] Diastolic to Systolic Velocity Ratio of Coronary Artery Flow at Basal Condition Indicates Coronary Microvessel Spasm in Normal Coronary Angiography. (2010)
  • Author(s): Ohba K, Sugiyama S, Nozaki T, Akiyama E, Matsubara J, Maeda H, Sumida H, Takashio S, Kanazawa H, Chitose T, Enomoto K, Ono T, Yamamoto K, Yamamoto E, Tanaka T, Morihisa K, Tsujita K, Nagayoshi Y, Izumiya Y, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Yamabe H, Ogawa H.
  • Organizer: 83rd American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, IL, USA McCormick Place
  • Year and Date: 2010-11-13
• [Presentation] C/ebp Homologous Protein Deficiency Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis and Inflammation (2010)
  • Author(s): Miyazaki Y, Kaikita K, Horio E, Yamamuro M, Tsujita K, Hokimoto S, Ogawa H, Oike Y.
  • Organizer: 83rd American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, IL, USA McCormick Place
  • Year and Date: 2010-11-13
• [Presentation] Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis (2010)
  • Author(s): Horio E, Kaikita K, Tabata M, Zhe T, Tazume H, Miyata K, Miyazaki Y, Ono T, Sato K, Tsujita K, Hokimoto S, Sumida H, Sugiyama S, Ogawa H, Oike Y.
  • Organizer: 83rd American Heart Association Scientific Sessions
  • Place of Presentation: Chicago IL.USA McCormick Place
  • Year and Date: 2010-11-13
• [Presentation] Functional CYP2C19 Gene Variants are Associated With Both On-clopidogrel Platelet Adhesiveness and Aggregation in Japanese Patients With Coronary Artery Disease (2010)
  • Author(s): Kaikita K, Ono T, Hokimoto S, Tsujita K, Miyazaki Y, Sato K, Horio E, Sumida H, Sugiyama S, Ogawa H.
  • Organizer: 83rd American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, IL, USA McCormick Place
  • Year and Date: 2010-11-13
• [Presentation] 待機的経皮的冠動脈インターベンション後の血中好感度トロポニンT濃度の上昇と寄与因子に関する検討 (2010)
  • Author(s): 小野敬道, 海北幸一, 佐藤幸治, 堀尾英治, 千年忠祐, 宮崎勇次, 辻田賢一, 坂本憲治, 田山信至、掃本誠治、角田等、杉山正悟、山部浩茂、小川久雄
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-09-17
• [Presentation] たこつぼ型心筋症におけるST上昇と合併症の関係 (2010)
  • Author(s): 高潮征爾, 山室恵, 森久健二, 辻田賢一, 海北幸一, 掃本誠治, 角田等, 杉山正悟, 中尾浩一, 小川久雄
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-09-17
• [Presentation] 特発性収縮性心膜炎に対して、ステロイド投与が著効した一例 (2010)
  • Author(s): 平田快絋, 森久健二, 坂本憲治, 辻田賢一, 海北幸一, 角田等, 杉山正悟, 小川久雄
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-09-17
• [Presentation] 慢性完全閉塞に対する冠動脈インターベンションにおける逆行性アプローチの順行性アプローチとの比較-血管内超音波スタディー- (2010)
  • Author(s): 辻田賢一
  • Organizer: 第19回日本心血管インターベンション治療学会シンポジウム
  • Place of Presentation: 仙台(宮城県)仙台国際ホテル
  • Year and Date: 2010-08-23
• [Presentation] Are all proton pump inhibitors associated with platelet reactivity in patients on dual Antiplatelet therapy undergoing coronary stent implantation. (2010)
  • Author(s): Hokimoto S, Yamamoto K, Ono T, Tsujita K, Kaikita K, Sumida H, Sugiyama S, Nakagawa K, Miyagawa H, Ogawa H.
  • Organizer: 第19回日本心血管インターベンション治療学会
  • Place of Presentation: 仙台(宮城県)仙台国際ホテル
  • Year and Date: 2010-08-23
• [Presentation] A Case of Coronary Thrombus due to Coronary Spastic Angina. (2010)
  • Author(s): Nagayoshi Y, Ohba K, Sumida H, Hokimoto S, Tsujita K, Sakamoto K, Yumoto S, Tajima T, Nakamura S, Kuroda Y, Sugiyama S, Ogawa H.
  • Organizer: 第19回日本心血管インターベンション治療学会
  • Place of Presentation: 仙台(宮城県)仙台国際ホテル
  • Year and Date: 2010-08-23
• [Presentation] 自然発症型冠動脈解離による急性心筋梗塞を発症した閉経前女性の1例 (2010)
  • Author(s): 宮崎貴志, 辻田賢一, 坂本憲治, 森久健二, 上村孝史, 海北幸一, 掃本誠治, 杉山正悟, 角田等, 中村淳, 山部浩茂, 小川久雄
  • Organizer: 第108回日本循環器学会九州地方会
  • Place of Presentation: 社団法人アクロス福岡(福岡県)
  • Year and Date: 2010-06-26
• [Presentation] 冠動脈疾患患者におけるチトクロームP4502C19遺伝子多型がクロピドグレルの血小板反応に与える影響 (2010)
  • Author(s): 山本浩一朗, 掃本誠治, 小野敬道, 辻田賢一, 海北幸一, 角田等, 杉山正悟, 小川久雄, 出口真理子, 中川和子
  • Organizer: 第108回日本循環器学会九州地方会
  • Place of Presentation: 社団法人アクロス福岡(福岡県)
  • Year and Date: 2010-06-26
• [Presentation] PCPSにより救命できたpheochromocytoma multisystem crisis (2010)
  • Author(s): 榎本耕治, 坂本憲治, 小島淳, 上村孝史, 森久健二, 辻田賢一, 泉家康宏, 山室恵, 海北幸一, 掃本誠治, 角田等, 杉山正悟, 山部浩茂, 小川久雄
  • Organizer: 第108回日本循環器学会九州地方会
  • Place of Presentation: 社団法人アクロス福岡(福岡県)
  • Year and Date: 2010-06-26
• [Presentation] 冠攣縮性狭心症から急性心筋梗塞を来たしたことが疑われた一症例 (2010)
  • Author(s): 大庭圭介, 永吉靖央, 角田等, 小西正紹, 秋山英一, 高潮征爾, 小野敬道, 山本浩一朗, 上村孝史, 森久健二, 辻田賢一, 坂本憲治, 山室恵, 泉家康宏, 堀端洋子, 小島淳, 海北幸一, 掃本誠治, 杉山正悟, 山部浩茂, 小川久雄
  • Organizer: 第108回日本循環器学会九州地方会
  • Place of Presentation: 社団法人アクロス福岡(福岡県)
  • Year and Date: 2010-06-26
• [Presentation] ヒス束近傍起源の心室性期外収縮に対しEnSiteシステムガイド下の治療が有効であった一例 (2010)
  • Author(s): 尾上喜郎, 森久健二, 榎本耕治, 上村孝史, 田中靖章, 坂本憲治, 辻田賢一, 山室恵, 海北幸一, 掃本誠治, 角田等, 杉山正悟, 山部浩茂, 小川久雄
  • Organizer: 第108回日本循環器学会九州地方会
  • Place of Presentation: 社団法人アクロス福岡(福岡県)
  • Year and Date: 2010-06-26
• [Presentation] Chronic Total Coronary Occlusion : Lesion Morphology Evaluated by Intravascular Ultrasound (2010)
  • Author(s): Tsujita K.
  • Organizer: 4th Coronary Interventional Imaging CIVUS Heart Lecture
  • Place of Presentation: Seoul, Korea(invited lecture)
  • Year and Date: 2010-06-05
• [Presentation] Chronic Total Coronary Occlusion : Lesion Morphology Evaluated by Intravascular Ultrasound (2010)
  • Author(s): Tsujita K
  • Organizer: 4th Coronary Interventional Imaging CIVUS Heart Lecture
  • Place of Presentation: Chung-Ang University Hospital, Seoul, Korea(招待講演)
  • Year and Date: 2010-06-05
• [Presentation] Diastolic to Systolic Velocity Ratio of Coronary Artery Flow at Basal Condition Indicates Coronary Microvessel Spasm in Normal Coronary Angiography. Circulation 2010 ; 122 : A13738 (2010)
  • Author(s): Ohba K, Sugiyama S, Nozaki T, Akiyama E, Matsubara J, Maeda H, Sumida H, Takashio S, Kanazawa H, Chitose T, Enomoto K, Ono T, Yamamoto K, Yamamoto E, Tanaka T, Morihisa K, Tsujita K, Nagayoshi Y, Izumiya Y, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokim
  • Organizer: 83rd American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Functional CYP2C19 Gene Variants are Associated With Both On-clopidogrel Platelet Adhesiveness and Aggregation in Japanese Patients With Coronary Artery Disease. Circulation 2010 ; 122 : A13656 (2010)
  • Author(s): Kaikita K, Ono T, Hokimoto S, Tsujita K, Miyazaki Y, Sato K, Horio E, Sumida H, Sugiyama S, Ogawa H.
  • Organizer: 83rd American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, IL, USA
• [Presentation] C/ebp Homologous Protein Deficiency Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis and Inflammation. Circulation 2010 ; 122 : A12879 (2010)
  • Author(s): Miyazaki Y, Kaikita K, Horio E, Yamamuro M, Tsujita K, Hokimoto S, Ogawa H, Oike Y.
  • Organizer: 83rd American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Angiopoietin-Like Protein2(angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis. Circulation 2010 ; 122 : A11343 (2010)
  • Author(s): Horio E, Kaikita K, Tabata M, Zhe T, Tazume H, Miyata K, Miyazaki Y, Ono T, Sato K, Tsujita K, Hokimoto S, Sumida H, Sugiyama S, Ogawa H, Oike Y.
  • Organizer: 83rd American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, IL, USA
• [Book] 心疾患における抗凝固・抗血小板療法,血栓止血誌 (2012)
  • Author(s): 副島弘文, 海北幸一, 掃本誠治, 辻田賢一, 小川久雄
• [Book] 血栓止血誌 (2012)
  • Author(s): 副島弘文, 海北幸一, 掃本誠治, 辻田賢一, 小川久雄
  • Publisher: 心疾患における抗凝固・抗血小板療法
• [Book] 狭心症の薬物治療 (2010)
  • Author(s): 辻田賢一, 海北幸一, 小川久雄
  • Publisher: medicina
• [Book] 循環器薬の使い方.コツと落とし穴-1.循環器疾患の薬物治療-Overview-d.狭心症 (2010)
  • Author(s): 山本英一郎, 辻田賢一, 千年忠祐, 掃本誠治, 小川久雄
  • Publisher: Heart View
• [Book] ACS基礎研究の進歩:発症関連因子 (2010)
  • Author(s): 辻田賢一, 海北幸一, 副島弘文, 杉山正悟, 小川久雄
  • Publisher: 日本臨牀社