| Project/Area Number |
22790718
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | HMGB-1 / RAGE / マトリックスメタロプロテアーゼ / 動脈硬化 / シグナル伝達 / 血管炎症 / マトリックスメタロブロテアーゼ |
|---|
| Research Abstract |
HMGB-1, which is an important mediator in vascular inflammation, causes the phosphorylation of NF-kB and activation of RhoA/Rac1 through AGE receptors in endothelial cells. Tissue factor is upregulated via these signaling pathways. We provide the evidence that MT1-MMP modulates these signal transductions. We also mentioned for the first time to regulation of the expression of endothelial NO synthase by HMGB-1. These results will be reported in the European Society of Cardiology in 2012.
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