| Project/Area Number |
22790723
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 臨床心血管病態学 / 単球 / 不安定プラーク / 冠動脈CT / サロゲートマーカー |
|---|
| Research Abstract |
Monocytes play an active role in coronary artery disease. Monocytes in human peripheral blood are heterogeneous. Differential expression of CD14 and CD16 enables monocytes to be divided into two subsets : CD14+CD16. monocytes and CD14+CD16+monocytes, called as "inflammatory" and "pro-inflammatory". We examined the relation between monocyte subsets and vulnerability characteristics of coronary plaques by using multidetector computed tomography. In our results, the relative proportion of CD14+CD16+monocytes was positively correlated with remodeling index and negatively correlated with CT attenuation value. Furthermore, we investigated the involvement of Toll-like receptor 4(TLR4) expression on two monocyte subsets in the pathologic processes related to acute coronary syndrome. The expression levels of TLR4 on CD14+CD16+monocytes were significantly elevated in patients with AMI. Moreover, the up-regulation of TLR4 on admission was remarkably decreased at the chronic phase after AMI. TLR overexpression on CD14+CD16+monocytes in AMI might be associated with the pathogenesis of AMI. In conclusion, CD14+CD16+monocytes show a potential for a surrogate marker of vulnerable plaques and acute coronary syndrome.
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