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Asssociation of monocyte subsets with vulnerablity characteristics of coronary plaque

Research Project

Project/Area Number 22790723
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionWakayama Medical University

Principal Investigator

KASHIWAGI Manabu  和歌山県立医科大学, 医学部, 学内助教 (70453181)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords臨床心血管病態学 / 単球 / 不安定プラーク / 冠動脈CT / サロゲートマーカー
Research Abstract

Monocytes play an active role in coronary artery disease. Monocytes in human peripheral blood are heterogeneous. Differential expression of CD14 and CD16 enables monocytes to be divided into two subsets : CD14+CD16. monocytes and CD14+CD16+monocytes, called as "inflammatory" and "pro-inflammatory". We examined the relation between monocyte subsets and vulnerability characteristics of coronary plaques by using multidetector computed tomography. In our results, the relative proportion of CD14+CD16+monocytes was positively correlated with remodeling index and negatively correlated with CT attenuation value. Furthermore, we investigated the involvement of Toll-like receptor 4(TLR4) expression on two monocyte subsets in the pathologic processes related to acute coronary syndrome. The expression levels of TLR4 on CD14+CD16+monocytes were significantly elevated in patients with AMI. Moreover, the up-regulation of TLR4 on admission was remarkably decreased at the chronic phase after AMI. TLR overexpression on CD14+CD16+monocytes in AMI might be associated with the pathogenesis of AMI. In conclusion, CD14+CD16+monocytes show a potential for a surrogate marker of vulnerable plaques and acute coronary syndrome.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2010

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Differential expression of Toll-like receptor 4 and human monocyte subsets in acute myocardial infarction2012

    • Author(s)
      Kashiwagi M, Imanishi T, Ozaki Y, Satogami K, Masuno T, Wada T, NakataniY, Ishibashi K, Komukai K, Tanimoto T, Ino Y, Kitabata H, Akasaka T
    • Journal Title

      Atherosclerosis

      Volume: 221 Issue: 1 Pages: 249-53

    • DOI

      10.1016/j.atherosclerosis.2011.12.030

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of monocyte subsets with vulnerability characteristics of coronary plaques as assessed by 64-slice multidetector computed tomography in patients with stable angina pectoris2010

    • Author(s)
      Kashiwagi M, Imanishi T, Tsujioka H, Ikejima H, Kuroi A, Ozaki Y, Ishibashi K, Komukai K, Tanimoto T, Ino Y, Kitabata H, Hirata K, Akasaka T
    • Journal Title

      Atherosclerosis

      Volume: 212 Issue: 1 Pages: 171-6

    • DOI

      10.1016/j.atherosclerosis.2010.05.004

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of monocyte subsets with vulnerability characteristics of coronary plaques assessed by 64-slice multidetector computed tomography in patients with stable angina pectoris2010

    • Author(s)
      Manabu Kashiwagi
    • Journal Title

      Atherosclerosis

      Volume: 212 Pages: 171-176

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト末梢血単球と冠動脈CTを用いて評価した冠動脈プラークの不安定性の関連性の検討2010

    • Author(s)
      柏木学
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト末梢血単球と冠動脈CTを用いて評価した冠動脈プラークの不安定性の関連性の検討2010

    • Author(s)
      柏木学
    • Organizer
      第58回 心臓病学会 総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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