Research Project
Grant-in-Aid for Young Scientists (B)
We generated iPS cells from patients with hypertrophic cardiomyopathy(HCM) and unaffected healthy volunteers. We also succeeded to differentiate generated iPS cells into cardiomyocytes in vitro reproducibly. Although we examined the various aspects of functional characteristics of iPS cells-derived cardiomyocytes and did not find those of significant differences in both cells, we clarified that the administration of X factor known as promoting cardiac hypertrophy highly induced cellular hypertrophy and disarray of alignment in structural proteins in HCM patient iPS cells-derived cardiomyocytes. Such phenomenon indicated that the difference of cellular response against X factor can contribute to onset of HCM.
All 2012 2011 2010
All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) Book (4 results)
J Mol Cell Cardiol
Volume: 52(3) Issue: 3 Pages: 650-9
10.1016/j.yjmcc.2011.11.010
Stem cells international
Volume: 348960
Volume: 348960 Pages: 1-7
10.4061/2011/348960
Circulation Research
Volume: 106(6) Pages: 1083-1091
Cell Sem Cell
Volume: 7(1) Pages: 11-15
