Epigenomic analysis of DNA methylation pattern in cardiomyocyte development and evaluation of stem cell differentiation methods.
Project/Area Number |
22790730
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
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Research Institution | Keio University |
Principal Investigator |
ODA Mayumi 慶應義塾大学, 医学部, 助教 (80567511)
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Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | DNAメチル化 / エピゲノム / 細胞特異的遺伝子発現 / 心筋細胞 / 転写調節 / 細胞種特異的遺伝子発現 / エピジェネティクス / 細胞分化 / ゲノムワイド / 次世代シークエンサー / 幹細胞 / バイオインフォマティクス |
Research Abstract |
Epigenome is thought to represent the developmental potential of given cells. However, it has been unknown where is the genomic regions that define the ability of cells, like stemness or spectrum of cell-type specific potentials. In this study, we sought
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects.2012
Author(s)
Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, Fukuda K, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H.
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Journal Title
Circulation Journal
Volume: 76
Pages: 1703-1711
NAID
Related Report
Peer Reviewed
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[Journal Article] Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome.2011
Author(s)
Suzuki M, Oda M, Ramos MP, Pascual M, Lau K, Stasiek E, Agyiri F, Thompson RF, Glass JL, Jing Q, Sandstrom R, Fazzari MJ, Hansen RS, Stamatoyannopoulos JA, McLellan AS, Greally JM
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Journal Title
Genome Research
Volume: 21
Pages: 1833-1840
Related Report
Peer Reviewed
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[Journal Article] Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects.2011
Author(s)
Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, Fukuda K, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H
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Journal Title
Circulation Journal
Volume: 76
Pages: 1703-1711
NAID
Related Report
Peer Reviewed
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[Presentation] DNA Methylation Changes in The b-MHC Locus Mediate Gene Regulation by Antisense RNA in Postnatal Cardiomyocyte Development.2011
Author(s)
Mayumi Oda, Shinji Makino, Shinsuke Yuasa, Sung Han Yoon, Yuta Higashikuse, Kojiro Yae, Ruri Kaneda, Mitsushige Murata, Motoaki Sano, John M. Greally and Keiichi Fukuda
Organizer
American Heart Association, Scientific Sessions
Place of Presentation
オーランド(アメリカ)
Related Report
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[Presentation] DNA Methylation Changes in The b-MHC Locus Mediate Gene Regulation by Antisense RNA in Postnatal Cardiomyocyte Development2011
Author(s)
Mayumi Oda, Shinji Makino, Shinsuke Yuasa, Sung Han Yoon, Yuta Higashikuse, Kojiro Yae, Ruri Kaneda, Mitsushige Murata, Motoaki Sano, John M. Greally and Keiichi Fukuda
Organizer
American Heart Association, Scientific Sessions
Place of Presentation
オーランド(アメリカ)
Related Report
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