| Project/Area Number |
22790732
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Showa University |
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Principal Investigator |
|
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| Research Collaborator |
YAMAYA Sayaka 昭和大学, 大学院・医学研究科, 博士
SPEES Jeffrey バーモント大学, 医学部, 准教授
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|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 骨髄間葉系幹細胞 / 血管新生 / 末梢動脈疾患 / エリスロポエチン / CD271 |
|---|
| Research Abstract |
The aim of this study was to develop novel therapeutic angiogenesis using mesenchymal stem cells(MSCs) from bone marrow. Both MSCs from total mononuclear cells and CD271+cells in bone marrow have shown pro-angiogenic phenotype. Preconditioning with erythropoietin enhanced the pro-angiogenic property in MSCs. MSC from bone marrow is useful cell source for therapeutic angiogenesis. MSC implantation combined with erythropoietin may become a new strategy for therapeutic angiogenesis in peripheral artery disease.
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