The Impact of Intensive Glycemic Control on Stablization of Coronary Vulnerable Plaque in Patients with Diabetes Mellitus
| Project/Area Number |
22790736
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
FUJII Kenichi 兵庫医科大学, 医学部, 講師 (90434943)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 冠動脈不安定粥腫 / 糖尿病 / 動脈硬化 / 冠動脈不安全粥腫 |
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| Research Abstract |
OCT was performed in all 3 major coronary arteries of 70 patients with acute myocardial infarction to evaluate the impact of diabetes mellitus on the incidence of coronary vulnerable plaque. The incidences of TCFA at culprit lesions were similar. However, non-culprit-lesion TCFAs were observed more frequently in diabetic patients than in non-diabetic patients.
Then, diabetic patients were randomly allocated to intensive glycemic control, targeting a glycosylated hemoglobin(HbA1c) level<6.5%, or standard glycemic control, targeting an HbA1c level of> 7.0%. However, there were no significant differences observed in percent changes in the fibrous cap thickness, lipid arc, and volume of lipidic component between patients with intensive glycemic control and patients with standard treatment.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Multiple Complex Coronary Atherosclerosis in Diabetic Patients with Acute Myocardial Infarction : A Three-Vessel Optical Coherence Tomography Study2012
Author(s)
Fukunaga M, Fujii K, Kawasaki D, Akahori H, Nakata T, Shibuya M, Kawai K, Masutani M, Lee-Kawabata M, Tsujino T, Ohyanagi M, Masuyama T.
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Journal Title
Eurointervention
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] The impact of pravastatin pre-treatment on periprocedural microcirculatory damage in patients undergoing percutaneous coronary intervention2011
Author(s)
Fujii K, Kawasaki D, Oka K, Akahori H, Iwasaku T, Fukunaga M, Eguchi A, Sawada H, Masutani M, Lee-Kawabata M, Tsujino T, Ohyanagi M, Masuyama T.
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Journal Title
JACC Cardiovasc Interv
Volume: 4(5)
Pages: 513-20
Related Report
Peer Reviewed
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[Journal Article] Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation2011
Author(s)
Fujii K, Kawasaki D, Oka K, Akahori H, Fukunaga M, Sawada H, Masutani M, Lee-Kawabata M, Tsujino T, Ohyanagi M, Masuyama T.
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Journal Title
Heart
Volume: 97(12)
Pages: 977-82
Related Report
Peer Reviewed
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