Novel Mechanisms of Chronic Heart Failure with Anemia
Project/Area Number |
22790737
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Hyogo Medical University |
Principal Investigator |
NAITO Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 循環器・高血圧 / 内科 / 基礎 / 高血圧・循環器 |
Research Abstract |
We revealed that angiotensin II type 1a receptor(AT1aR) and erythropoietin receptor(EpoR) signal pathways are involved in the mechanism of iron deficiency induced cardiac remodeling. Dietary iron-restricted EpoR rescued mice, which express EpoR only in the hematopoietic lineage, demonstrated anemia and systolic dysfunction, thereby inducing heart failure and decreasing a survival rate. On the other hand, AT1aR knock-out mice attenuated Epo secretion in response to iron deficiency. As a result, our data suggests that modulation of AT1aR and cardiac EpoR signaling may represent a therapeutic target for anemia-induced heart failure.
|
Report
(3 results)
Research Products
(38 results)
-
-
-
[Journal Article] Involvement of bone morphogenetic protein-binding endothelial regulator in aortic valve stenosis2011
Author(s)
Sawada H, Naito Y, Hirotani S, Akahori H, Iwasaku T, Eguchi A, Okuhara Y, Fujii A, Ohyanagi M, Mitsuno M, Miyamoto Y, Tsujino T, Masuyama T.
-
Journal Title
Int J Cardiol.
Volume: 152
Pages: 107-109
Related Report
Peer Reviewed
-
[Journal Article] Role of plasma aldosterone concentration in regression of left-ventricular mass following antihypertensive medication2011
Author(s)
Yoshida C, Goda A, Naito Y, Nakaboh A, Matsumoto M, Otsuka M, Ohyanagi M, Hirotani S, Lee-Kawabata M, Tsujino T, Masuyama T.
-
Journal Title
J Hypertens.
Volume: 29
Pages: 357-363
Related Report
Peer Reviewed
-
[Journal Article] Administration of angiotensin-converting enzyme inhibitors is associated with slow progression of mild aortic stenosis in Japanese patients2011
Author(s)
Wakabayashi K, Tsujino T, Naito Y, Ezumi A, Lee-Kawabata M, Nakao S, Goda A, Sakata Y, Yamamoto K, Daimon T, Masuyama T.
-
Journal Title
Heart Vessels.
Volume: 26
Pages: 252-257
Related Report
Peer Reviewed
-
[Journal Article] Intraleaflet hemorrhage is associated with rapid progression of degenerative aortic valve stenosis2011
Author(s)
Akahori H, Tsujino T, Naito Y, Matsumoto M, Lee-Kawabata M, Ohyanagi M, Mitsuno M, Miyamoto Y, Daimon T, Hao H, Hirota S, Masuyama T.
-
Journal Title
Eur Heart J.
Volume: 32
Pages: 888-896
Related Report
Peer Reviewed
-
-
-
[Journal Article] Involvement of bone morphogenetic protein-binding endothelial regulator in aortic valve stenosis2011
Author(s)
Sawada H, Naito Y, Hirotani S, Akahori H, Iwasaku T, Eguchi A, Okuhara Y, Fujii A, Ohyanagi M, Mitsuno M, Miyamoto Y, Tsujino T, Masuyama T
-
Journal Title
Int J Cardiol
Volume: 152
Pages: 107-109
Related Report
Peer Reviewed
-
[Journal Article] Role of plasma aldosterone concentration in regression of left-ventricular mass following antihypertensive medication2011
Author(s)
Yoshida c, Goda A, Naito Y, Nakaboh A, Matsumoto M, Otsuka M, Ohyanagi M, Hirotani S, Lee-Kawabata M, Tsujino T, Masuyama T
-
Journal Title
J Hypertens
Volume: 29
Pages: 357-363
Related Report
Peer Reviewed
-
[Journal Article] Administration of angiotens in-converting enzyme inhibitors is associated with slow progression of mild aortic stenosis in Japanese patients2011
Author(s)
Wakabayashi K, Tsujino T, Naito Y, Ezumi A, Lee-Kawabata M, Nakao S, Goda A, Sakata Y, Yamamoto K, Daimon T, Masuyama T
-
Journal Title
Heart Vessels
Volume: 26
Pages: 252-257
Related Report
Peer Reviewed
-
[Journal Article] Intraleaflet hemorrhage is associated with rapid progression of degenerative aortic valve stenosis2011
Author(s)
Akahori H, Tsujino T, Naito Y, Matsumoto M, Lee-Kawabata M, Ohyanagi M, Mitsuno M, Miyamoto Y, Daimon T, Hao H, Hirota S, Masuyama T
-
Journal Title
Eur Heart J
Volume: 32
Pages: 888-896
Related Report
Peer Reviewed
-
[Journal Article] Determinants of plasma brain natriuretic peptide levels in untreated hypertensive patients2011
Author(s)
Goda A, Nakao S, Tsujino T, Yuba M, Otsuka M, Matsumoto M, Yoshida C, Naito Y, Lee-Kawabata M, Ohyanagi M, Masuyama T
-
Journal Title
J Echocardiogr
Volume: 9
Pages: 103-108
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Increased interleukin-18 expression in nonrheumatic aortic valve stenosis2010
Author(s)
Naito Y, Tsujino T, Wakabayashi K, Matsumoto M, Ohyanagi M, Mitsuno M, Miyamoto Y, Hao H, Hirota S, Okamura H, Masuyama T.
-
Journal Title
Int J Cardiol.
Volume: 144
Pages: 260-263
Related Report
Peer Reviewed
-
-
-
-
-
[Presentation] 心アミロイドーシスによる心不全に対してV2-受容体拮抗剤が著効した1例2011
Author(s)
西本健太, 中坊亜由美, 廣谷信一, 中聡夫, 岩破俊博, 内藤由朗, 江口明世, 澤田悠, 川端正明, 大柳光正, 増山理
Organizer
第111回日本循環器学会近畿地方会
Place of Presentation
神戸
Year and Date
2011-06-25
Related Report
-
-
-
[Presentation] 大動脈弁狭窄症弁組織におけるBone morphogenetic protein-binding endothelial regulator(BMPER)発現2011
Author(s)
澤田悠, 内藤由朗, 辻野健, 奥原祥貴, 江口明世, 岩破俊博, 赤堀宏州, 廣谷信一, 大柳光正, 光野正孝, 宮本裕治, 増山理
Organizer
第59回日本心臓病学会学術集会
Place of Presentation
神戸
Related Report
-
-
[Presentation] Statin use reduces neoangiogenesis and intraleaflet hemorrhage in the aortic valve of degenerative aortic stenosis2011
Author(s)
Akahori H, Tsujino T, Naito Y, Yoshida C, Fujii K, Lee-Kawabata M, Sakoda T, Mitsuno M, Miyamoto Y, Ohyanagi M, Masuyama T
Organizer
第75回日本循環器学会総会・学術集会
Place of Presentation
横浜
Related Report
-
-
-
-
-
[Presentation] Neoangiogenesis, intraleaflet haemorrhage and macrophage infiltration are more remarkable in bicuspid aortic valve stenosis than in tricuspid aortic valve stenosis2011
Author(s)
Akahori H, Tsujino T, Naito Y, Yoshida C, Sasaki N, Lee-Kawabata M, Ohyanagi M, Mitsuno M, Miyamoto Y, Masuyama T
Organizer
European Society of Cardiology Congress 2011
Place of Presentation
France
Related Report
-
-
-
-