| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We focused on dendritic cells(DCs) which are the most potent antigen-presenting cells. We demonstrated that the numbers and activation markers of DCs were correlated with cardiac function, clinical parameters and prognosis in patients with decompensated heart failure. We also investigated whether DCs would be involved in the pathogenesis of heart failure using mice myocarditis model. Autoimmune myocarditis and heart failure were induced by DCs pulsed with cardiac antigen peptide. These autoimmune myocarditis and heart failure were attenuated by simvastatin. We also examined the effects of simvastatin on activation markers and cytokines production of DCs in vitro. Simvastatin significantly suppressed activation markers and inflammatory cytokines. These results suggest that DCs may play a role in the pathogenesis of heart failure and simvastatin may suppress dendritic cell-induced autoimmune myocarditis, possibly by inhibiting the activation and inflammatory cytokines production of DCs.
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