Association between cerebrovascular disease and store-operated calcium channe

• Project/Area Number: 22790740
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukuoka Dental College
• Principal Investigator: KURUSHIMA Hideaki 福岡歯科大学, 歯学部, 助教 (70550870)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳血管障害 / 動脈硬化 / カルシウムイオン

Research Abstract

A rise in cytoplasmic Ca2+concentration is a key messenger of cell signaling. STIM1 is a sensor of cytoplasmic Ca2+concentration and regulates store-operated calcium entry(SOCE). A strong immunoreactivity of STIM1 was detected aroud aortic plaques in mice. We hypothesize that STIM1 determines whether monocyte differentiates into pro-inflammatory M1 macrophage or anti-inflammatory M2 macrophage. We are verifying it in established monocyte cell lines and human primary monocytes.