γ-secretase Inhibitor Enhances Antitumor Effect of Radiation in Notch Expressing Lung Cancer
| Project/Area Number |
22790742
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAKAKIBARA Jun (KONISHI Jun) 北海道大学, 北海道大学病院, 助教 (50374278)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺癌 / Notch / 放射線治療 |
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| Research Abstract |
We discovered that the antitumor effect of combining GSI(-secretase inhibitor) and radiation was dependent on treatment schedule. GSI administration after radiation had the greatest growth inhibition of lung cancer in vitro and in vivo. We showed that the combination induced apoptosis of lung cancer cell lines through the regulation of MAPK and Bcl-2family proteins. Furthermore, activation of Notch after radiation was ameliorated by GSI administration, suggesting that treatment with GSI prevent Notch-induced radiation resistance.
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Report
(3 results)
Research Products
(5 results)
